Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70

Advances in Experimental Medicine and Biology

Volumn 451, Issue , 1998, Pages 353-357

  Douin Echinard, V ^a   Robbins, P D ^b   Lotze, M T ^b   Favre, G ^a   Couderc, B ^a  

^a INSTITUT CLAUDIUS REGAUD   (France)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BREAST TUMOR; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FIBROBLAST; GENETIC ENGINEERING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TUMOR CELL CULTURE; TUMOR IMMUNITY;

EID: 0031723748     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5357-1_55     Document Type: Article

References (8)

1. K.E. Hellstrom and I. Hellstrom, 1991: Principles of tumor immunity: tumor antigens. In the Biologic Therapy of Cancer. V.T. DE Vita, Jr., S. Hellman, and S.A. Rosenberg, eds. (Philadelphia: J.B. Lippincott Compagny), 35-52
2. R.H. Schwartz, 1989: Acquisition of immunological self-tolerance. Cell 57, 1073-10815
3. H. Tahara, H.J. Zeh III, W.J. Storkus, I. Pappo, S.C. Watkins, U Gubler,S.F. Wolf, P Robbins and M.T. Lotze, 1994: Fibroblasts genetically engineered to secrete Interleukine 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res. 54, 182-189.
4. S.E. Townsend and J.P. Allison, 1993: Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 259, 368-370.
5. S.H. Chan, B. Perrussia, J.W. Gupta, M. Kobayashi, H.A. Pospisil, S.F. Wolf, D. Young, S.C. Clark and G. Trinchieri, 1991: Induction of IFNg production by NKSF: characterisation of the responder cells and synergy with other inducers. J. Exp. Med. 173, 869-879
6. L. Zitvogel, P.D. Robbins, W.J. Storkus, M.R. Clarke, M.J. Maeurer, R.L. Campbell, C.G. Davis, H. Tahara, R.D. Schreiber and M.T. Lotze, 1996: CD80 Costimulation Markedly Enhances IL-12-Mediated Antitumor Immunity in vivo. Eur. J. Immunol. 26, 1335-1341.
7. R.Q. Hintzen, S.M. Lens, K Lammers, H. Kuiper, M.P. Beckmann and R.A. Van Lier, 1995: Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation. J. Immunol. 154, 2612-2623
8. E. M. Elder, M.T. Lotze and T.L. Whiteside, 1996: Successful culture and selection of cytokine gene-modified human dermal fibroblasts for the biologic therapy of patients with cancer. Human Gene Therapy 7, 479-487