A monoclonal antibody directed against human von Willebrand factor induces type 2B-like alterations

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 9, 2004, Pages 1622-1628

  Ulrichts, H ^d   Harsfalvi, J ^a   Bene, L ^a   Matko, J ^a   Vermylen, J ^b   Ajzenberg, N ^c   Baruch, D ^c   Deckmyn, Hans ^d   Tornai, I ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c INSERM   (France)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

A domain; Shear stress; Von Willebrand's disease

Indexed keywords

COLLAGEN; EPITOPE; GLYCOPROTEIN IB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1C1E7; PROTEIN ANTIBODY; PROTEIN SUBUNIT; RISTOCETIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INCUBATION TIME; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SHEAR RATE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; VISCOMETER; VON WILLEBRAND DISEASE;

ANTIBODIES, MONOCLONAL; EPITOPES; FLOW CYTOMETRY; HUMANS; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PROTEIN SUBUNITS; RISTOCETIN; VON WILLEBRAND DISEASE; VON WILLEBRAND FACTOR;

EID: 13244259181     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2004.00865.x     Document Type: Article

References (34)

1. Ruggeri ZM. Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation. Best Pract Res Clin Haematol 2001; 14: 257-79.
2. Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell 1998; 94: 657-66.
3. Siedlecki CA, Lestini BJ, Kottke-Marchant KK, Eppell SJ, Wilson DL, Marchant RE. Shear-dependent changes in the three-dimensional structure of human von Willebrand factor. Blood 1996; 88: 2939-50.
4. Novak L, Deckmyn H, Damjanovich S, Harsfalvi J. Shear-dependent morphology of von Willebrand factor bound to immobilized collagen. Blood 2002; 99: 2070-6.
5. Savage B, Sixma JJ, Ruggeri ZM. Functional self association of von Willebrand factor during platelet adhesion under flow. Proc Natl Acad Sci USA 2002; 99: 425-30.
6. Savage B, Saldivar E, Ruggeri ZM. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 1996; 84: 289-97.
7. Savage B, Cattaneo M, Ruggeri ZM. Mechanisms of platelet aggregation. Curr Opin Hematol 2001; 8: 270-6.
8. Miura S, Li CQ, Cao Z, Wang H, Wardell MR, Sadler JE. Interaction of von Willebrand factor domain A1 with platelet glycoprotein Ib alpha-(1-289). Slow intrinsic binding kinetics mediate rapid platelet adhesion. J Biol Chem 2000; 275: 7539-46.
9. Uff S, Clemetson JM, Harrison T, Clemetson KJ, Emsley J. Crystal structure of the platelet glycoprotein Ibalpha N-terminal domain reveals an unmasking mechanism for receptor activation. J Biol Chem 2002; 277: 35657-63.
10. Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science 2002; 297: 1176-9.
11. Sadler JE. Biomedicine. Contact - how platelets touch von Willebrand factor. Science 2002; 297: 1128-9.
12. Tornai I, Arnout J, Deckmyn H, Peerlinck K, Vermylen J. A monoclonal antibody recognizes a von Willebrand factor domain within the amino-terminal portion of the subunit that modulates the function of the glycoprotein IB- and IIB/IIIA-binding domains. J Clin Invest 1993; 91: 273-82.
13. Vermylen J, Donati MB, De Gaetano G, Verstraete M. Aggregation of human platelets by bovine or human factor VIII: role of carbohydrate side chains. Nature 1973; 244: 167-8.
14. Vicente V, Houghten RA, Ruggeri ZM. Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding. J Biol Chem 1990; 265: 274-80.
15. Read MS, Smith SV, Lamb MA, Brinkhous KM. Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor. Blood 1989; 74: 1031-5.
16. Budde U, Schneppenheim R. Von Willebrand factor and von Willebrand disease. Rev Clin Exp Hematol 2001; 5: 335-68.
17. Meyer D, Fressinaud E, Hilbert L, Ribba AS, Lavergne JM, Mazurier C. Type 2 von Willebrand disease causing defective von Willebrand factor-dependent platelet function. Best Pract Res Clin Haematol 2001; 14: 349-64.
18. Emsley J, Cruz M, Handin R, Liddington R. Crystal structure of the von Willebrand factor A1 domain and implications for the binding of platelet glycoprotein Ib. J Biol Chem 1998; 273: 10396-401.
19. de Groot PG, Federici AB, de Boer HC, d'Alessio P, Mannucci PM, Sixma JJ. von Willebrand factor synthesized by endothelial cells from a patient with type IIB von Willebrand disease supports platelet adhesion normally but has an increased affinity for platelets. Proc Natl Acad Sci USA 1989; 86: 3793-7.
20. Sugimoto M, Matsui H, Mizuno T, Tsuji S, Miyata S, Matsumoto M, Matsuda M, Fujimura Y, Yoshioka A. Mural thrombus generation in type 2A and 2B von Willebrand disease under flow conditions. Blood 2003; 101: 915-20.
21. Depraetere H, Ajzenberg N, Girma JP, Lacombe C, Meyer D, Deckmyn H, Baruch D. Platelet aggregation induced by a monoclonal antibody to the A1 domain of von Willebrand factor. Blood 1998; 91: 3792-9.
22. Coller BS, Peerschke EI, Scudder LE, Sullivan CA. Studies with a murine monoclonal antibody that abolishes ristocetin- induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor. Blood 1983; 61: 99-110.
23. Tornai I, Declerck PJ, Smets L, Arnout J, Deckmyn H, Caekebeke-Peerlinck KM, Vermylen J. Measurement of von Willebrand factor antigen in plasma and platelets with an enzyme-linked immunosorbent assay based on two murine monoclonal antibodies. Haemostasis 1991; 21 125-34.
24. Deckmyn H, Stanssens P, Hoet B, Declerck PJ, Lauwereys M, Gansemans Y, Tornai I, Vermylen J. An echistatin-like Arg-Gly-Asp (RGD)-containing sequence in the heavy chain CDR3 of a murine monoclonal antibody that inhibits human platelet glycoprotein IIb/IIIa function. Br J Haematol 1994; 87: 562-71.
25. Ruggeri ZM, Zimmerman TS. The complex multimeric composition of factor VIII/von Willebrand factor. Blood 1981; 57: 1140-3.
26. Matko J, Edidin M. Energy transfer methods for detecting molecular clusters on cell surfaces. Methods Enzymol 1997; 278 444-62.
27. O'Brien JR, Salmon GP. Shear stress activation of platelet glycoprotein IIb/IIIa plus von Willebrand factor causes aggregation: filter blockage and the long bleeding time in von Willebrand's disease. Blood 1987; 70: 1354-61.
28. Harsfalvi J, Stassen JM, Hoylaerts MF, Van Houtte E, Sawyer RT, Vermylen J, Deckmyn H. Calin from Hirudo medicinalis, an inhibitor of von Willebrand factor binding to collagen under static and flow conditions. Blood 1995; 85: 705-11.
29. Wu D, Vanhoorelbeke K, Cauwenberghs N, Meiring M, Depraetere H, Kotze HF, Deckmyn H. Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons. Blood 2002; 99: 3623-8.
30. Lankhof H, Damas C, Schiphorst ME, Ijsseldijk MJ, Bracke M, Sixma JJ, Vink T, de Groot PG. Functional studies on platelet adhesion with recombinant von Willebrand factor type 2B mutants R543Q and R543W under conditions of flow. Blood 1997; 89: 2766-72.
31. Pareti FI, Cattaneo M, Carpinelli L, Zighetti ML, Bressi C, Mannucci PM, Ruggeri ZM. Evaluation of the abnormal platelet function in von Willebrand disease by the blood filtration test. Thromb Haemost 1996; 76: 460-8.
32. Nakagawa-Nishimura Y, Sugimoto M, Tsuji S, Kuwahara M, Nishio K, Takahashi Y, Fujimura Y, Murata M, Handa M, Ikeda Y. Shear stress-induced platelet aggregation in various types of von Willebrand disease. Int J Hematol 1995; 61: 189-96.
33. Boda Z, Tornai I, Rak K. Studies of the platelet filter test (shear dependent platelet aggregation) in patients with uncommon haemorrhagic disorders. Blood Coagul Fibrinolysis 1996; 7: 162-4.
34. Christophe O, Rouault C, Obert B, Pietu G, Meyer D, Girma JP. A monoclonal antibody (B724) to von Willebrand factor recognizing an epitope within the A1 disulphide loop (Cys509-Cys695) discriminates between type 2A and type 2B von Willebrand disease. Br J Haematol 1995; 90: 195-203.