PDGF-A, PDGF-B, TGFβ, and bFGF mRNA levels in patients with essential thrombocythemia treated with anagrelide

American Journal of Hematology

Volumn 78, Issue 2, 2005, Pages 155-157

  Lev, Paola R ^a   Salim, Juan P ^a   Kornblihtt, Laura I ^a   Pirola, Carlos J ^a   Marta, Rosana F ^a   Heller, Paula G ^a   Molinas, Felisa C ^a  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

Author keywords

Anagrelide; bFGF; Essential thrombocythemia; PDGF; TFG

Indexed keywords

ANAGRELIDE; BASIC FIBROBLAST GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; GENE AMPLIFICATION; GENE EXPRESSION; HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTHEMIA;

BLOOD PLATELETS; FIBROBLAST GROWTH FACTOR 2; GROWTH SUBSTANCES; HUMANS; MIDDLE AGED; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-SIS; QUINAZOLINES; RNA, MESSENGER; THROMBOCYTHEMIA, HEMORRHAGIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 13244258484     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20268     Document Type: Article

References (9)

1. Castro-Malaspina H, Rabellino EM, Yen A, Nachman RL, Moore MAS. Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts. Blood 1981;57:781-787.
2. Martyré MC, Le Bousse-Kerdiles MC, Romquin N, et al. Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis. Br J Haematol 1997;97:441-448.
3. Lev PR, Marta RF, Vassallu P, Molinas FC. Variation of PDGF, TGFβ and bFGF levels in essential thrombocythemia patients treated with anagrelide. Am J Hematol 2002;70:85-91.
4. Murphy S, Peterson P, Hand H, Lazlo J. Experience of the Polycythemia Vera Study Group with essential thrombocythemia: a final report on diagnostic criteria, survival, and leukemic transition by treatment. Semin Hematol 1997;34:29-39.
5. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann Biochem 1987;162:156-159.
6. Rocca B. Ciabattoni G, Tartaglione R, et al. Increased thromboxane biosynthesis in essential thrombocythemia. Thromb Haemost 1995;74:1225-1230.
7. Laguna MS, Kornblihtt LI, Marta RF, Molinas FC. Tromboxano β2 y factor de crecimiento derivado de las plaquetas en la trombocitemia esencial tratada con anagrelide. Medicina 2000;60:448-452.
8. Thiele J, Kvasnicka HM, Fuchs N, Brunnbauer K, Volkwein N, Schmitt-Graeff A. Anagrelide-induced bone marrow changes during therapy of chronic myeloproliferative disorders with thrombocytosis. An immunohistochemical and morphometric study of sequential trephine biopsies. Haematologica 2003;88:1130-1138.
9. Solberg LA, Tefferi A, Oles KJ, et al. The effects of anagrelide on human megacaryocytopoiesis. Br J Haematol 1997;99:174-180.