Role of fungus in eosinophilic sinusitis

Current Opinion in Otolaryngology and Head and Neck Surgery

Volumn 13, Issue 1, 2005, Pages 9-13

  Gosepath, Jan ^a,b   Mann, Wolf J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Chronic rhinosinusitis; Eosinophilic reaction; Fungi; Immunologic sensitization

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CHITINASE; CLOTRIMAZOLE; FUNGAL DNA; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 5; ITRACONAZOLE; MUCIN;

ALLERGIC REACTION; ALTERNARIA; CHRONIC SINUSITIS; CILIARY MOTILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FUNGAL DETECTION; HUMAN; HYPEREOSINOPHILIA; LYMPHOCYTE; MYCOSIS; NOSE MUCUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIOALLERGOSORBENT TEST; REVIEW; RHINOSINUSITIS; SYSTEMATIC REVIEW; TH2 CELL;

CHRONIC DISEASE; EOSINOPHILIA; FUNGI; HUMANS; MYCOSES; NASAL CAVITY; NASAL MUCOSA; RHINITIS; SINUSITIS;

EID: 13244256959     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/00020840-200502000-00004     Document Type: Review

References (37)

1. Lanza DC: Diagnosis of chronic rhinosinusitis. Ann Otol Rhinol Laryngol Suppl 2004; 193:10-14. A comprehensive review on the current state-of-the-art work-up for chronic rhinosinusitis.
2. Ferguson BJ: Categorization of eosinophilic chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2004; 12:237-242. Great article detailing the variety of subcategories of eosinophilic chronic rhinosinusitis in the light of recent findings, including mechanisms like aspirin sensitization and superantigen-induced reactions.
3. Kennedy DW: Pathogenesis of chronic rhinosinusitis. Ann Otol Rhinol Laryngol Suppl 2004; 193:6-9. Review on the broad range of predisposing factors for chronic rhinosinusitis, dividing them into host and nonhost factors.
4. Lund VJ, Kennedy DW: Quantification for staging sinusitis: the staging and therapy group. Ann Otol Rhinol Laryngol Suppl 1995; 167:17-21.
5. Ponikau JU, Sherris DA, Kern EB, et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 1999; 74:877-884.
6. Davidsson A, Hellquist HB: The so-called "allergic" nasal polyp. ORL J Otorhinolatyngol Relat Spec 1993; 55:30-35.
7. Kaldenbach T, Schafer D, Gosepath J, et al. Significance of eosinophilic granulocytes in relation to allergy and aspirin intolerance in patients with sinusitis polyposa. Laryngorhinootologie 1999; 8:429-434.
8. Taylor MJ, Ponikau JU, Sherris DA, et al. Detection of fungal organisms in eosinophilic mucin using a fluorescin-labeled chitin-specific binding protein. Otolaryngol Head Neck Surg 2002; 127:377-383.
9. Braun H, Buzina W, Freudenschuss K, et al. Eosinophilic fungal rhinosinusitis: a common disorder in Europe? Laryngoscope 2002; 112:1-6.
10. Gosepath J, Brieger J, Vlachtsis K, et al. Fungal DNA is present in tissue specimens of patients with chronic rhinosinusitis. Am J Rhinol 2004; 18: 9-13. This article presents a new aspect as the investigators identify fungal DNA using PCR on surgical specimens from paranasal tissue in a well-controlled way.
11. Davis LJ, Kita H: Pathogenesis of chronic rhinosinusitis: role of airborne fungi and bacteria. Immunol Allergy Clin North Am 2004; 24:59-73. The article presents interesting immunologic data on the potential role of airborne organisms in chronic rhinosinusitis, including both fungi and bacteria.
12. Riechelmann H: Fungi and polyps: facts and myths. Latyngorhinootologie 2003; 82:766-768.
13. Hamilos DL, Lund VJ: Etiology of chronic rhinosinusitis: the role of fungus. Ann Otol Rhinol Latyngol Suppl 2004; 193:27-31. This is an excellent review shedding some light on the current definition of allergic fungal sinusitis, discussing some of the recent findings of a general T-cell sensitization to fungi in chronic rhinosinusitis patients.
14. Schubert MS: Allergic fungal sinusitis. Otolaryngol Clin North Am 2004; 37:301-326. This review gives an insight into the different etiologic hypotheses discussed in AFS.
15. DeShazo RD, Chapin K, Swain RE: Fungal sinusitis. N Engl J Med 1997; 337:254-261.
16. Hamilos DL: Chronic sinusitis. J Allergy Clin Immunol 2000; 106:213-227.
17. Cody DT II, Neel HB III, Ferreiro JA, et al. Allergic fungal sinusitis: the Mayo Clinic experience. Laryngoscope 1994; 104:1074-1079.
18. Morpeth JF, Rupp NT, Dolen WK, et al. Fungal sinusitis: an update. Ann Allergy Clin Immunol 1996; 76:128-139.
19. Katzenstein A, Sale SR, Greenberger PA: Allergic Aspergillus sinusitis: a newly recognized form of sinusitis. J Allergy Clin Immunol 1983; 72:89-93.
20. Braun H, Stammberger H, Buzina W, et al. Incidence and detection of fungi and eosinophilic granulocytes in chronic rhinosinusitis. Latyngorhinootologie 2003; 82:330-340. This is an important article to the proposed hypothesis of EFRS. A European center presents detailed data that confirm some of the key findings previously proposed by Mayo researchers.
21. Weschta M, Rimek D, Formanek M, et al. Local production of Aspergillus fumigatus specific immunoglobulin E in nasal polyps. Laryngoscope 2003; 113:1798-1802.
22. Collins M, Nair S, Smith W, et al. Role of local immunoglobulin E production in the pathophysiology of noninvasive fungal sinusitis. Laryngoscope 2004; 114:1242-1246. Original article that focuses on the rare but important aspect of local IgE against fungal organisms in the nose without simultaneous systemic IgE.
23. Buzina W, Braun H, Freudenschuss K, et al. Fungal biodiversity-as found in nasal mucus. Med Mucol 2003; 41:149-161. Using both culture and PCR, authors show the impressive biodiversity of fungi in nasal mucus, identifying the most prevalent species.
24. Lackner A, Freudenschuss K, Buzina W, et al. From when on can fungi be B identified in nasal mucus of- humans? Laryngorhinootologie 2004; 83:117-121. This study from the group from Graz concludes that fungi can be cultured from the nasal mucus of neonates as soon as contact to environmental air exists.
25. Catten M, Murr AH, Goldstein JA, et al. Detection of fungi in the nasal mucosa using PCR. Laryngoscope 2001; 111:399-403.
26. Hendolin PH, Paulin L, Koukila-Kahkola P, et al. Panfungal PCR and multiplex liquid hybridization for detection of fungi in tissue specimens. J Clin Microbiol 2000; 38:4186-4192.
27. Pillal SD: Rapid molecular detection of microbial pathogens: breakthroughs and challenges. Arch Virol Suppl 1997; 13:67-82.
28. Perez-Jaffe LA, Lanza DC, Loevner LA, et al. In situ hybridization for aspergillus and penicillinum in allergic fungal sinusitis: a rapid means of speciating fungal pathogens in tissues. Laryngoscope 1997; 107:223-240.
29. Schueller MC, Murr AH, Goldberg AN, et al. Quantitative analysis of fungal DNA in chronic rhinosinusitis. Laryngoscope 2004; 114:467-471. This study correlates the quantity of fungal DNA found in the middle meatus to a quality of life assay; however, no significant correlation is detected, because fungal DNA is equally detected in chronic rhinosinusitis patients and healthy controls.
30. Wei JL, Kita H, Sherris DA, et al. The chemotactic behavior of eosinophils in patients with chronic rhinosinusitis. Laryngoscope 2003; 113:303-306. This article details the chemotactic behavior of eosinophilic granulocytes in the presence of certain cytokines, including interleukin-5 and interleukin-13.
31. Shin SH, Kita H: Recent advances in the etiology of sinusitis: fungi as a cause of sinusitis. J Allergy Clin Immunol 2001; 107:3163.
32. Ponikau JU, Sherris DA, Kephart GM, et al. Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma? J Allergy Clin Immunol 2003; 112:877-882. Authors present novel data on the histopathologic similarities between asthma and chronic rhinosinusitis.
33. Ponikau JU, Sherris DA, Kita H, et al. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol 2002; 110:862-866. Open-label pilot trial, however uncontrolled, on the use of amphotericin B as a topical treatment in chronic rhinosinusitis, presenting optimistic data on efficacy in 51 patients.
34. Ricchetti A, Landis BN, Maffioli A, et al. Effect of antifungal nasal lavage with amphotericin B on nasal polyposis. J Laryngol Otol 2002; 116:261-263.
35. Ferguson BJ: Antifungal nasal washes for chronic rhinosinusitis: what's therapeutic-the wash or the antifungal? J Allergy Clin Immunol 2003; 111: 1137-1138.
36. Weschta M, Rimek D, Formanek M, et al. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double blind clinical trial. J Allergy Clin Immunol 2004; 113:1122-1128. A first trial on topical antifungal treatment in chronic rhinosinusitis in a randomized, double-blind design with no therapeutic effect of amphotericin B spray in the described dosing and time schedule.
37. Gosepath J, Grebneva N, Mossikhin S, et al. Topical antibiotic, antifungal, and antiseptic solutions decrease ciliary activity in nasal respiratory cells. Am J Rhinol 2002; 16:25-31.