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Volumn 131, Issue 2, 2005, Pages 129-136

A hybrid protein of the amino-terminal fragment of urokinase and mutant plasminogen activator inhibitor-2 efficiently inhibits tumor cell invasion and metastasis

Author keywords

Hybrid protein; Tumor cell invasion; Urokinase plasminogen activator

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; FIBRONECTIN; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLASMINOGEN ACTIVATOR INHIBITOR 2; UROKINASE;

EID: 13244256811     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-004-0623-2     Document Type: Article
Times cited : (7)

References (41)
  • 1
    • 0030788411 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in cancer metastasis: A review
    • Andreasen PA, Kjoller L, Christensen L, Duffy MJ (1997) The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 72:1-22
    • (1997) Int J Cancer , vol.72 , pp. 1-22
    • Andreasen, P.A.1    Kjoller, L.2    Christensen, L.3    Duffy, M.J.4
  • 2
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2:563-572
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 3
    • 0038364216 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy
    • Sidenius N, Blasi F (2003) The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy. Cancer Metastasis Rev 22:205-222
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 205-222
    • Sidenius, N.1    Blasi, F.2
  • 4
    • 0033981473 scopus 로고    scopus 로고
    • The plasminogen activator system in tumor growth, invasion, and metastasis
    • Andreasen PA, Egelund R, Petersen HH (2000) The plasminogen activator system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57:25-40
    • (2000) Cell Mol Life Sci , vol.57 , pp. 25-40
    • Andreasen, P.A.1    Egelund, R.2    Petersen, H.H.3
  • 5
    • 0035127868 scopus 로고    scopus 로고
    • The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis
    • Wang Y (2001) The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis. Med Res Rev 21:146-170
    • (2001) Med Res Rev , vol.21 , pp. 146-170
    • Wang, Y.1
  • 6
    • 0026063532 scopus 로고
    • Cellular receptor for urokinase plasminogen activator. Carboxyl- terminal processing and membrane anchoring by glycosyl- phosphatidylinositol
    • Ploug M, Ronne E, Behrendt N, Jensen AL, Blasi F, Dano K (1991) Cellular receptor for urokinase plasminogen activator. Carboxyl- terminal processing and membrane anchoring by glycosyl- phosphatidylinositol. J Biol Chem 266:1926-1933
    • (1991) J Biol Chem , vol.266 , pp. 1926-1933
    • Ploug, M.1    Ronne, E.2    Behrendt, N.3    Jensen, A.L.4    Blasi, F.5    Dano, K.6
  • 7
    • 0025900910 scopus 로고
    • The ligand-binding domain of the cell surface receptor for urokinase- Type plasminogen activator
    • Behrendt N, Ploug M, Patthy L, Houen G, Blasi F, Dano K (1991) The ligand-binding domain of the cell surface receptor for urokinase- type plasminogen activator. J Biol Chem 266:7842-7847
    • (1991) J Biol Chem , vol.266 , pp. 7842-7847
    • Behrendt, N.1    Ploug, M.2    Patthy, L.3    Houen, G.4    Blasi, F.5    Dano, K.6
  • 8
    • 0028569183 scopus 로고
    • Identification of the urokinase receptor as an adhesion receptor for vitronectin
    • Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA (1994) Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 269:32380-32388
    • (1994) J Biol Chem , vol.269 , pp. 32380-32388
    • Wei, Y.1    Waltz, D.A.2    Rao, N.3    Drummond, R.J.4    Rosenberg, S.5    Chapman, H.A.6
  • 10
    • 0035036704 scopus 로고    scopus 로고
    • Analysis of expressions of components in the plasminogen activator system in high- And low-metastatic human lung cancer cells
    • He C, He P, Liu LP, Zhu YS (2001) Analysis of expressions of components in the plasminogen activator system in high- and low-metastatic human lung cancer cells. J Cancer Res Clin Oncol 127:180-186
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 180-186
    • He, C.1    He, P.2    Liu, L.P.3    Zhu, Y.S.4
  • 11
    • 0035488532 scopus 로고    scopus 로고
    • Antisense RNA for urokinase receptor inhibits the invasiveness and metastasis of lung carcinoma
    • Liao JH, Xu SH, Tang HB, Lian FZ, Zhu YS (2001) Antisense RNA for urokinase receptor inhibits the invasiveness and metastasis of lung carcinoma. Chin J Pathol 30:357-360
    • (2001) Chin J Pathol , vol.30 , pp. 357-360
    • Liao, J.H.1    Xu, S.H.2    Tang, H.B.3    Lian, F.Z.4    Zhu, Y.S.5
  • 12
    • 20444377327 scopus 로고    scopus 로고
    • The protection function of the PAI-2 from TNF-α is dependent upon its protein binding domain
    • Tian Y, Shen JQ, Li P, Zhu YS (2000) The protection function of the PAI-2 from TNF-α is dependent upon its protein binding domain. Acta Biochim Biophys Sincia 32:175-178
    • (2000) Acta Biochim Biophys Sincia , vol.32 , pp. 175-178
    • Tian, Y.1    Shen, J.Q.2    Li, P.3    Zhu, Y.S.4
  • 13
    • 0031817915 scopus 로고    scopus 로고
    • The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis
    • Dickinson JL, Norris BJ, Jensen PH, Antalis TM (1998) The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis. Cell Death Differ 5:163-171
    • (1998) Cell Death Differ , vol.5 , pp. 163-171
    • Dickinson, J.L.1    Norris, B.J.2    Jensen, P.H.3    Antalis, T.M.4
  • 14
    • 0026741960 scopus 로고
    • A hybrid protein of urokinase growth-factor domain and plasminogen- Activator inhibitor type 2 inhibits urokinase activity and binds to the urokinase receptor
    • Ballance DJ, Marshall JM, Cottingham IR, Steven J, Berry SJ, Cederholm-Williams SA, Goodey AR, Courtney M (1992) A hybrid protein of urokinase growth-factor domain and plasminogen- activator inhibitor type 2 inhibits urokinase activity and binds to the urokinase receptor. Eur J Biochem 207:177-183
    • (1992) Eur J Biochem , vol.207 , pp. 177-183
    • Ballance, D.J.1    Marshall, J.M.2    Cottingham, I.R.3    Steven, J.4    Berry, S.J.5    Cederholm-Williams, S.A.6    Goodey, A.R.7    Courtney, M.8
  • 15
    • 0346551793 scopus 로고    scopus 로고
    • Inhibition of invasiveness of human breast cancer cells by antisense RNA for urokinase receptor
    • Xu SH, Liao JH, Zhu YS (2000) Inhibition of invasiveness of human breast cancer cells by antisense RNA for urokinase receptor. Chin J Biochem Mol Biol 16:814-819
    • (2000) Chin J Biochem Mol Biol , vol.16 , pp. 814-819
    • Xu, S.H.1    Liao, J.H.2    Zhu, Y.S.3
  • 19
    • 0026660349 scopus 로고
    • Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein
    • Busk M, Pytela R, Sheppard D (1992) Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. J Biol Chem 267:5790-5796
    • (1992) J Biol Chem , vol.267 , pp. 5790-5796
    • Busk, M.1    Pytela, R.2    Sheppard, D.3
  • 20
    • 0023142975 scopus 로고
    • Embryonic neural retinal cell response to extracellular matrix proteins: Developmental changes and effects of the cell substratum attachment antibody (CSAT)
    • Hall DE, Neugebauer KM, Reichardt LF (1987) Embryonic neural retinal cell response to extracellular matrix proteins: developmental changes and effects of the cell substratum attachment antibody (CSAT). J Cell Biol 104:623-634
    • (1987) J Cell Biol , vol.104 , pp. 623-634
    • Hall, D.E.1    Neugebauer, K.M.2    Reichardt, L.F.3
  • 21
    • 0027953557 scopus 로고
    • Role of activated protein C in facilitating basement membrane invasion by tumor cells
    • Kobayashi H, Moniwa N, Gotoh J, Sugimura M, Terao T (1994) Role of activated protein C in facilitating basement membrane invasion by tumor cells. Cancer Res 54:261-267
    • (1994) Cancer Res , vol.54 , pp. 261-267
    • Kobayashi, H.1    Moniwa, N.2    Gotoh, J.3    Sugimura, M.4    Terao, T.5
  • 22
    • 0036906177 scopus 로고    scopus 로고
    • uPAR: A versatile signalling orchestrator
    • Blasi F, Carmeliet P (2002) uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 3:932-943
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-943
    • Blasi, F.1    Carmeliet, P.2
  • 23
    • 0033052090 scopus 로고    scopus 로고
    • The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer
    • Cox G, Steward WP, O'Byrne KJ (1999) The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer. Thorax 54:169-179
    • (1999) Thorax , vol.54 , pp. 169-179
    • Cox, G.1    Steward, W.P.2    O'Byrne, K.J.3
  • 24
    • 0034933664 scopus 로고    scopus 로고
    • The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer
    • Mazar AP (2001) The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer. Anticancer Drugs 12:387-400
    • (2001) Anticancer Drugs , vol.12 , pp. 387-400
    • Mazar, A.P.1
  • 25
    • 0026672589 scopus 로고
    • The effect of recombinant plasminogen activator inhibitor 2(PAI-2) on the growth of a human tumor cell line in vitro and in vivo
    • Shinkfield MNF, Burnand KG, Balance DJ, Zitka M, Eastham D (1992) The effect of recombinant plasminogen activator inhibitor 2(PAI-2) on the growth of a human tumor cell line in vitro and in vivo. Fibrinolysis 6 [Suppl 4]:59-65
    • (1992) Fibrinolysis , vol.6 , Issue.4 SUPPL. , pp. 59-65
    • Shinkfield, M.N.F.1    Burnand, K.G.2    Balance, D.J.3    Zitka, M.4    Eastham, D.5
  • 26
    • 0032993493 scopus 로고    scopus 로고
    • Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors
    • Praus M, Wauterickx K, Collen D, Gerard RD (1999) Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors. Gene Ther 6:227-236
    • (1999) Gene Ther , vol.6 , pp. 227-236
    • Praus, M.1    Wauterickx, K.2    Collen, D.3    Gerard, R.D.4
  • 27
    • 0029009388 scopus 로고
    • Suppression of pulmonary metastases of rat mammary cancer by recombinant urokinase plasminogen activator inhibitor
    • Evans DM, Lin PL (1995) Suppression of pulmonary metastases of rat mammary cancer by recombinant urokinase plasminogen activator inhibitor. Am Surg 61:692-697
    • (1995) Am Surg , vol.61 , pp. 692-697
    • Evans, D.M.1    Lin, P.L.2
  • 28
    • 0028202550 scopus 로고
    • Inhibition of the metastasis of Lewis lung carcinoma by antibody against urokinase-type plasminogen activator in the experimental and spontaneous metastasis model
    • Kobayashi H, Gotoh J, Shinohara H, Moniwa N, Terao T (1994) Inhibition of the metastasis of Lewis lung carcinoma by antibody against urokinase-type plasminogen activator in the experimental and spontaneous metastasis model. Thromb Haemost 71:474-480
    • (1994) Thromb Haemost , vol.71 , pp. 474-480
    • Kobayashi, H.1    Gotoh, J.2    Shinohara, H.3    Moniwa, N.4    Terao, T.5
  • 29
    • 0037089470 scopus 로고    scopus 로고
    • Urokinase receptor antibody can reduce tumor volume and detect the presence of occult tumor metastases in vivo
    • Rabbani SA, Gladu J (2002) Urokinase receptor antibody can reduce tumor volume and detect the presence of occult tumor metastases in vivo. Cancer Res 62:2390-2397
    • (2002) Cancer Res , vol.62 , pp. 2390-2397
    • Rabbani, S.A.1    Gladu, J.2
  • 30
    • 0037102259 scopus 로고    scopus 로고
    • An antiangiogenic urokinase-derived peptide combined with tamoxifen decreases tumor growth and metastasis in a syngeneic model of breast cancer
    • Guo Y, Mazar AP, Lebrun JJ, Rabbani SA (2002) An antiangiogenic urokinase-derived peptide combined with tamoxifen decreases tumor growth and metastasis in a syngeneic model of breast cancer. Cancer Res 62:4678-4684
    • (2002) Cancer Res , vol.62 , pp. 4678-4684
    • Guo, Y.1    Mazar, A.P.2    Lebrun, J.J.3    Rabbani, S.A.4
  • 31
    • 17544363650 scopus 로고    scopus 로고
    • A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo
    • Guo Y, Higazi AA, Arakelian A, Sachais BS, Cines D, Goldfarb RH, Jones TR, Kwaan H, Mazar AP, Rabbani SA (2000) A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo. FASEB J 14:1400-1410
    • (2000) FASEB J , vol.14 , pp. 1400-1410
    • Guo, Y.1    Higazi, A.A.2    Arakelian, A.3    Sachais, B.S.4    Cines, D.5    Goldfarb, R.H.6    Jones, T.R.7    Kwaan, H.8    Mazar, A.P.9    Rabbani, S.A.10
  • 32
    • 0035833983 scopus 로고    scopus 로고
    • Peptide-derived antagonists of the urokinase receptor, affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation
    • Ploug M, Ostergaard S, Gardsvoll H, Kovalski K, Holst-Hansen C, Holm A, Ossowski L, Dano K (2001) Peptide-derived antagonists of the urokinase receptor, affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation. Biochemistry 40:12157-12168
    • (2001) Biochemistry , vol.40 , pp. 12157-12168
    • Ploug, M.1    Ostergaard, S.2    Gardsvoll, H.3    Kovalski, K.4    Holst-Hansen, C.5    Holm, A.6    Ossowski, L.7    Dano, K.8
  • 33
    • 0013607373 scopus 로고
    • Recombinant PAI-2 inhibition of uPA producing tumors in SCID mice
    • Billstrom A, Lecander I, Astedt B (1994) Recombinant PAI-2 inhibition of uPA producing tumors in SCID mice. Fibrinolysis 8 [Suppl 1]:56
    • (1994) Fibrinolysis , vol.8 , Issue.1 SUPPL. , pp. 56
    • Billstrom, A.1    Lecander, I.2    Astedt, B.3
  • 34
  • 35
    • 0030908029 scopus 로고    scopus 로고
    • Integrins as signaling molecules and targets for tumor therapy
    • Ruoslahti E (1997) Integrins as signaling molecules and targets for tumor therapy. Kidney Int 51:1413-1417
    • (1997) Kidney Int , vol.51 , pp. 1413-1417
    • Ruoslahti, E.1
  • 36
    • 0031713433 scopus 로고    scopus 로고
    • Extracellular matrix signaling: Integration of form and function in normal and malignant cells
    • Boudreau N, Bissell MJ (1998) Extracellular matrix signaling: integration of form and function in normal and malignant cells. Curr Opin Cell Biol 10:640-646
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 640-646
    • Boudreau, N.1    Bissell, M.J.2
  • 37
    • 0037416209 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins
    • Czekay RP, Aertgeerts K, Curriden SA, Loskutoff DJ (2003) Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. J Cell Biol 60:781-791
    • (2003) J Cell Biol , vol.60 , pp. 781-791
    • Czekay, R.P.1    Aertgeerts, K.2    Curriden, S.A.3    Loskutoff, D.J.4
  • 38
    • 0029783254 scopus 로고    scopus 로고
    • Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin
    • Akamatsu H, Ichihara-Tanaka K, Ozono K, Kamiike W, Matsuda H, Sekiguchi K (1996) Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin. Cancer Res 56:4541-4546
    • (1996) Cancer Res , vol.56 , pp. 4541-4546
    • Akamatsu, H.1    Ichihara-Tanaka, K.2    Ozono, K.3    Kamiike, W.4    Matsuda, H.5    Sekiguchi, K.6
  • 39
    • 0031706183 scopus 로고    scopus 로고
    • Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis
    • Urtreger A, Porro F, Puricelli L, Werbajh S, Baralle FE, Joffe EBK, Kornblihtt AR, Muro AF (1998) Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis. Int J Cancer 78:233-241
    • (1998) Int J Cancer , vol.78 , pp. 233-241
    • Urtreger, A.1    Porro, F.2    Puricelli, L.3    Werbajh, S.4    Baralle, F.E.5    Ebk, J.6    Kornblihtt, A.R.7    Muro, A.F.8
  • 40
    • 0034782160 scopus 로고    scopus 로고
    • Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells
    • Ma Z, Webb DJ, Jo M, Gonias SL (2001) Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells. J Cell Sci 114:3387-3396
    • (2001) J Cell Sci , vol.114 , pp. 3387-3396
    • Ma, Z.1    Webb, D.J.2    Jo, M.3    Gonias, S.L.4
  • 41
    • 0032478829 scopus 로고    scopus 로고
    • Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility
    • Nguyen DH, Hussaini IM, Gonias SL (1998) Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility. J Biol Chem 273:8502-8507
    • (1998) J Biol Chem , vol.273 , pp. 8502-8507
    • Nguyen, D.H.1    Hussaini, I.M.2    Gonias, S.L.3


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