Histologic characterization of canine dilated cardiomyopathy

Veterinary Pathology

Volumn 42, Issue 1, 2005, Pages 1-8

  Tidholm, A ^a   Jonsson L ^b  

^a Albano Animal Hospital of Stockholm ^*  (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Canine; Cardiomyopathy; Dilated; Histology

Indexed keywords

CARDIOMYOPATHY; DIAGNOSTIC TEST; DIASTOLIC BLOOD PRESSURE; DOG; DOPPLER ECHOGRAPHY; ECHOCARDIOGRAPHY; NONHUMAN; REVIEW; SYSTOLIC BLOOD PRESSURE;

ANIMALS; CARDIOMYOPATHY, DILATED; DOG DISEASES; DOGS; ECHOCARDIOGRAPHY; FEMALE; HISTOCYTOCHEMISTRY; MALE;

CANIS FAMILIARIS;

EID: 13244255356     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.42-1-1     Document Type: Review

References (98)

1. Alroy J, Rush JE, Freeman L, Amarendhra Kumar MS, Karuri A, Chase K, Sarkar S: Inherited infantile dilated cardiomyopathy in dogs: genetic, clinical, biochemical, and morphologic findings. Am J of Med Genet 95:57-66, 2000
2. Archard LC, Bowles NE, Olsen EGJ, Richardson PJ: Detection of persistent coxsackie B virus RNA in dilated cardiomyopathy and myocarditis. Eur Heart J 8:437-440, 1987
3. Armstrong PW, Stopps TP, Ford SE: Rapid ventricular pacing in the dog: pathophysiological studies of heart failure. Circulation 74:1075, 1986
4. Atkins CE: The role of noncardiac disease in the development and precipitation of heart failure. Vet Clin North Am Small Anim Pract 21:1035-1080, 1991
5. Autore C, Fiorito S, Pelliccia A, Caselli G, Fragola PV, Picelli A, Maccari AM, Pocobelli D, Cannata D, Sangiorgi M: Antimitochondrial autoantibodies in myocardial hypertrophy: comparison between hypertrophic cardiomyopathy, hypertensive heart disease, and athlete's heart. Am Heart J 116:496-500, 1988
6. Barr SC: American trypanosomiasis in dogs. Compend Contin Ed 13:745-752, 1991
7. Barr SC, Simpson RM, Schmidt SP, Bunge MM, Authement JM, Lozano F: Chronic dilatative myocarditis caused by Trypanosoma cruzi in two dogs. J Am Vet Med Assoc 195:1237-1239, 1989
8. Basso C, Thiene G, Corrado D, Angelini A, Nava A, Valente M: Arrhythmogenic right ventricular cardiomyopathy (dysplasia, dystrophy or myocarditis?). Circulation 94:983-994, 1996
9. Borgarelli M, Tarducci A, Bussadori C, Santilli RA, Priano L: Echocardiographic and echoDoppler prognostic indicators in dogs with dilated cardiomyopathy. Eur Soc Vet Intern Med Annu Congr 7:25-28, 1997
10. Borgarelli M, Tarducci A, Tidholm A, Häggström A: Canine idiopathic dilated cardiomyopathy. Part II: pathophysiology and therapy. Vet J 162:182-185, 2001
11. Bowles NE, Bowles KR, Towbin JA: The "final common pathway" hypothesis and inherited cardiovascular disease. The role of cytoskeletal proteins in dilated cardiomyopathy. Herz 25:168-175, 2000
12. Bowles NE, Rose ML, Taylor P, Banner NR, Morgan-Capner P, Cunningham L, Archard LC, Yacoub MH: End-stage dilated cardiomyopathy: persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response. Circulation 80:1128-1136, 1989
13. Caforio ALP, Grazzini M, Mann JM, Keeling PJ: Identification of alpha-and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation 85:1734-1742, 1992
14. Calvert CA, Chapman WL, Toal RL: Congestive cardiomyopathy in Doberman Pinscher dogs. J Am Vet Med Assoc 181:598-602, 1982
15. Calvert CA, Hall G, Jacobs G, Pickus C: Clinical and pathologic findings in Doberman pinschers with occult cardiomyopathy that died suddenly or developed congestive heart failure: 54 cases (1984-1991). J Am Vet Med Assoc 210:505-511, 1997
16. Calvert CA, Pickus CW, Jacobs GJ, Brown J: Signalment, survival and prognostic factors in Doberman Pinschers with end-stage cardiomyopathy. J Vet Intern Med 11:323-326, 1997
17. Cambridge G, Mac Arthur CGC, Waterson AP, Goodwin JF, Oakley CM,: Antibodies to Coxsackie B viruses in congestive cardiomyopathy. Br Heart J 41:692-696, 1979
18. Cobb MA, Brownlie SE, Pidduck HG, Batt RM: Evidence for genetic involvement in dilated cardiomyopathy in the Irish Wolfhound. Annu Congr BSAVA 215, 1996
19. Cullen MJ, Mastalgia FL: Pathological reactions in skeletal muscle. In: Skeletal Muscle Pathology, ed. Mastalgia FL, and Walton J, pp. 88-139. Churchill Livingstone, Edinburgh, UK, 1982
20. d'Amati G, di Gioia CR, Giordano C, Gallo P: Myocyte transdifferentiation. A possible pathogenetic mechanism for arrhythmogenic right ventricular cardiomyopathy. Arch Pathol Lab Med 124:287-290, 2000
21. Dambach DM, Lannon A, Sleeper MM, Buchanan J: Familial dilated cardiomyopathy of young Portuguese water dogs. J Vet Intern Med 13:65-71, 1999
22. Davies MJ: The cardiomyopathies: a review of terminology, pathology and pathogenesis. Histopathology 8: 363-393, 1984
23. Dukes McEwan J: Dilated Cardiomyopathy in Newfoundlands. The Veterinary Cardiovascular Society Meeting. 2-4 1998 [Abstract]
24. Dukes-McEwan J: Echocardiographic/Doppler Criteria of Normality, the Findings in Cardiac Disease and the Genetics of Familial Dilated Cardiomyopathy in Newfoundland Dogs. University of Edinburgh, Edinburgh, UK, 318, 1999
25. Edwards WD: Cardiomyopathies. Human Pathol 18: 625-628, 1987
26. Eichbaum F: Wavy myocardial fibers in spontaneous and experimental adrenergic cardiopathies. Cardiology 60: 358-365, 1975
27. Eliot RS, Clayton FC, Todd P, Todd G: Influence of environmental stress on the pathogenesis of sudden cardiac death. Fed Proc 36:1719-1724, 1977
28. Ettinger S, Bolton G, Lord P: Idiopathic cardiomyopathy in the dog. J Am Vet Assoc 156:1225, 1970
29. Ettinger SJ, Benitz AM, Ericsson GF, Cifelli S, Jernigan AD, Longhofer SL, Trimboli W, Hanson PD: Effects of enalapril maleate on survival of dogs with naturally occurring acquired heart failure. J Am Vet Med Assoc 213: 1573-1577, 1998
30. Everett RM, McGann J, Wimberly HC, Althoff J: Dilated cardiomyopathy of Doberman pinschers: retrospective histomorphologic evaluation of heart from 32 cases. Vet Pathol 36:221-227, 1999
31. Fernández del Palacio MJ, Bernal LJ, Bayón A, Bernabé A, Montes de Oca R, Seva J: Arrhythmogenic right ventricular dysplasia/cardiomyopathy in a Siberian husky. J Small Anim Pract 42:137-141, 2001
32. Fujimoto S, Mizuno R, Nakagawa Y, Kimura A, Yamaji K, Yutani C, Dohi K, Nakano H: Ultrasonic tissue characterization in patients with dilated cardiomyopathy: comparison with findings from right ventricular endomyocardial biopsy. Int J Card Imaging 15:391-396, 1999
33. Gooding JP, Robinson WF, Wyburn RS, Cullen LK: A cardiomyopathy in the English Cocker Spaniel: a clinicopathological investigation. J Small Anim Pract 23:133-149, 1982
34. Grogan M, Smith HC, Gersh BJ, Wood D: Left ventricular dysfunction due to atrial fibrillation in patients initially believed to have dilated cardiomyopathy. Am J Cardiol 69:1570-1573, 1992
35. Harpster NK: Boxer cardiomyopathy. In: Current Veterinary Therapy VIII, ed. Kirk RW, pp. 329-337. WB Saunders, Philadelphia, PA, 1983.
36. Hazlett MJ, Maxie MG, Allen DG, Wilcock BP: A retrospective study of heart disease in Doberman pinscher dogs. Can Vet J 24:205-210, 1983
37. Izumi T, Hattori A, Higuma N, Tamura K: Cardiac myofibril disorientation and Z band abnormalities in idiopathic cardiomyopathy. An electron microscope study. Arch Histol Jpn 41:293-308, 1978
38. Keene BW: Canine cardiomyopathy. In: Current Veterinary Therapy X. Small Animal Practice, ed. Kirk RW, pp. 240-251. WB Saunders, Philadelphia, PA, 1989
39. Keene BW, Kittleson MD, Rush JE: Frequency of myocardial carnitine deficiency associated with spontaneous dilated cardiomyopathy. Proc Annu Vet Med Forum 6: 757, 1988
40. Keene BW, Panciera DL, Regitz V: Carnitine-linked defects of myocardial metabolism in canine dilated cardiomyopathy. Proc Am Coll Vet Intern Med 118, 1986
41. Keene BW, Panciera DP, Atkins CE, Regitz V, Schmidt MJ, Shug AL: Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy. J Am Vet Med Assoc 198:647-650, 1991
42. Kinoshita M, Takano H, Taenaka Y, Mori H, Takaichi S, Noda H, Tatsumi E, Yagura A, Seekii H, Akutsu T: Cardiac disuse atrophy during LVAD pumping. ASAIO Trans 34:208-212, 1988
43. Kittelson MD, Keene B, Pion PD, Loyer CG: Results of the multicenter spaniel trial (MUST): taurine- and carnitine-responsive dilated cardiomyopathy in American cocker spaniels with decreased plasma taurine concentration. J Vet Intern Med 11:204-211, 1997
44. Kittleson M: Left ventricular function - part I. Compend Contin Ed Pract Vet 16:287-305, 1994
45. Klein R, Maisch B, Kochsiek K, Berg PA: Demonstration of organ specific antibodies against heart mitochondria (anti-M7) in sera from patients with some forms of heart diseases. Clin Exp Immunol 58:283-292, 1984
46. Levy SA, Duray PH: Complete heart block in a dog seropositive for Borrelia burgdorferi. Similarity to human Lyme Carditis. J Vet Intern Med 2:138-144, 1988
47. Limas CJ: Autoimmunity in dilated cardiomyopathy and major histocompatibility complex. Int J Cardiol 54:113-116, 1996
48. Liu S-K, Hsu FS, Lee RCT: An Atlas of Cardiovascular Pathology. Wonder Enterprise Co., Taiwan, 1989
49. Liu S-K, Tashijan RJ, Patniak AK: Congestive heart failure in the cat. J Am Vet Med Assoc 156:1319-1330, 1970
50. Martin M, Celona B, King J, Strehlau G: A retrospective review of the clinical presentation and survival of 202 cases of canine dilated cardiomyopathy. Eur Soc Vet Intern Med Congr 11:99-100, 2001
51. McCarthy G: Idiopathic congestive cardiomyopathy of large breeds of dogs: observations on eleven cases. Irish Vet J 38:155-158, 1984
52. McCarthy PM, Nakatani S, Vargo R, Kottke-Marchant K, Harasaki H, James KB, Savage RM, Thomas JD: Structural and left ventricular histologic changes after implantable LVAD insertion. Ann Thorac Surg 59:609-613, 1995
53. McIntosh Bright J, McEntee M: Isolated right ventricular cardiomyopathy in a dog. J Am Vet Med Assoc 207:64-66, 1995
54. Meurs KM: Insight into the hereditability of canine cardiomyopathy. Vet Clin North Am Small Anim Pract 28:1449-1457, 1998
55. Meurs KM, Magnon AL, Spier AW, Miller MW, Lehmkuhl LB, Towbin JA: Evaluation of the cardiac actin gene in Doberman pinschers with dilated cardiomyopathy. J Vet Intern Med 13:247, 1999 [Abstract]
56. Michels VV, Moll PP, Miller FA, Tajik AJ, Chu JS, Driscoll DJ, Burnett, JC, Rodeheffer RJ, Chesebro JH, Tazelaar HD: The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N Eng J Med 9:77-82, 1992
57. Monnet E, Orton C, Salman M, Boon J: Idiopathic dilated cardiomyopathy in dogs: survival and prognostic indicators. J Vet Intern Med 9:12-17, 1995
58. Muir P, Tilzey AJ, English TAH, Nicholson F, Signy M, Banatvala JE: Chronic relapsing pericarditis and dilated cardiomyopathy: serological evidence of persistent enterovirus infection. Lancet 1989:804-806
59. Nakatani S, McCarthy PM, Kottke-Marchant K, Harasaki H, James KB, Savage RM, Thomas JD: Left ventricular echocardiographic and histologic changes: impact of chronic unloading by an implantable ventricular assist device. J Am Coll Cardiol 27:894-901, 1996
60. O'Brien PJ, lanuzzo CD, Moe GW, Stopps TP, Armstrong PW: Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies. Can J Physiol Pharmacol 68:34-38, 1990
61. Olsen EGJ: Pathology of primary cardiomyopathies. Postgrad Med J 48:732-737, 1972
62. Olsen EGJ: The pathogenesis of dilated cardiomyopathy. Postgrad Med J 68:S7-S10, 1992
63. Olson TM, Michels VV, Thibodeau SN, Tai Y, Keating MT: Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science 280:750-752, 1998
64. Pion PD, Kittleson MD, Rogers QR, Morris JG: Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science 237:764-768, 1987
65. Regitz V, Shug AL, Fleck E: Defective myocardial carnitine metabolism in congestive heart failure secondary to coronary, hypertensive, and valvular heart diseases. Am J Cardiol 65:755-759, 1990
66. Richardson P, McKenna W, Bristow M, Maisch B, Mautner B, O'Connell J, Olsen E, Thiene G, Goodwin J, Gyarfas I, Martin I, Nordet P: Report of the 1995 World Health Organisation/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93:637-640, 1996
67. Roberts WC, Ferrans VJ, Buja LM: Pathologic aspects of idiopathic cardiomyopathies. Comp Pathol Heart 13:349-367, 1974
68. Rossi MA: Chronic hemodynamic unloading regulates the morphologic development of newborn mouse hearts transplanted into the ear of isogenic adult mice. Am J Pathol 141:183-191, 1992
69. Sandusky GE, Capen CC, Kerr KM: Histological and ultrastructural evaluation of cardiac lesions in idiopathic cardiomyopathy in dogs. Can J Comp Med 48:81-86, 1984
70. Schatzberg SJ, Olby NJ, Breen M, Anderson LVB, Langford CF, Dickens HF, Wilton SD, Zeiss CJ, Binns MM, Kornegay JN, Morris GE, Sharp NJH: Molecular analysis of a spontaneous dystrophin "knockout" dog. Neuromuscul Disord 9:289-295, 1999
71. Scheinin S, Capek P, Radovancevic B, Duncan M, McAllister H, Frazier O: The effect of prolonged left ventricular support on myocardial histopathology in patients with end-stage cardiomyopathy. ASAIO J 38:M271-M274, 1992
72. Schultheiss HP, Bolte HD: Immunological analysis of auto-antibodies against the adenine nucleotide translocator in dilated cardiomyopathy. J Mol Cell Cardiol 17: 603-617, 1985
73. Schulze K, Becker BF, Schauer R, Schultheiss HP: Antibodies to ADP-ATP carrier - an autoantigen in myocarditis and dilated cardiomyopathy-impair cardiac function. Circulation 81:959-969, 1990
74. Seidman JG, Seiman C: The genetic basis for cardiomyopathy: from mutation to mechanistic paradigms. Cell 104:557-567, 2001
75. Simpson KW, Bonagura JD, Eaton KA: Right ventricular cardiomyopathy in a dog. J Vet Intern Med 8:306-309, 1994
76. Sisson D, O'Grady MR, Calvert CA: Myocardial diseases of dogs. In: Textbook of Canine and Feline Cardiology: Principles and Clinical Practice, ed. Fox PR, Sisson D, and Moise NS, pp. 581-619. WB Saunders, Philadelphia, PA 1999
77. Sleeper MM, Henthorn PS, Vijayasarathy C, Dambach DM, Bowers T, Tijskens P, Armstrong CF, Lankford EB: Dilated cardiomyopathy in juvenile Portugese water dogs. J Vet Intern Med 16:52-62, 2002.
78. Staaden RV: Cardiomyopathy of English Cocker Spaniels. J Am Vet Assoc 178:1289-1292, 1981
79. Stanek G, Klein J, Bittner R, Glogar D: Isolation of Borrelia burgdorferi from myocardium of a patient with longstanding cardiomyopathy. N Engl J Med 322:249-252, 1990
80. The Bench (Benazepril in canine heart disease) study group: The effect of benazepril on survival times and clinical signs of dogs with congestive heart failure: results of a multicenter, prospective, randomized, double-blinded, placebo-controlled long-term clinical trial. J Vet Cardiol 1:7-17, 1999
81. Thiene G, Nava A, Corrado D: Right ventricular cardiomyopathy and sudden death in young people. N Engl J Med 318:129-133, 1988
82. Tidholm A, Häggström J, Jönsson L: Prevalence of attenuated wavy fibers in the myocardium of dogs with dilated cardiomyopathy. J Am Vet Med Assoc 212:1732-1734, 1998
83. Tidholm A, Häggström J, Jönsson L: Detection of attenuated wavy fibers in the myocardium of Newfoundlands without clinical or echocardiographic evidence of heart disease. Am J Vet Res 61:238-241, 2000
84. Tidholm A, Jönsson L: Dilated cardiomyopathy in the New Foundland: a study of 37 cases (1983-1994). J Am Anim Hosp Assoc 32:465-470, 1996
85. Tidholm A, Jönsson L: A retrospective study of canine dilated cardiomyopathy (189 cases). J Am Anim Hosp Assoc 33:544-550, 1997
86. Tidholm A, Svensson H, Sylvén C: Survival and prognostic factors in 189 dogs with dilated cardiomyopathy. J Am Anim Hosp Assoc 33:364-368, 1997
87. Tidholm A, Svensson H, Sylvén C: Effects on survival of combination treatment with propranolol and thyroid hormone treatment or placebo in conjunction with digoxin and furosemide in euthoroid dogs with myocardial hypokinesia and congestive heart failure. Eur Soc Vet Intern Med Congr 11:159, 2001
88. Tilley LP, Liu S-K: Cardiomyopathy in the dog. Recent Adv Stud Cardiac Struct Metab 10:641-653, 1975
89. Towbin JA, Hejtmancik JF, Brink P, Gelb B, Zhu XM, Chamberlain JS, McCabe ERB, Swift M: X-linked cardiomyopathy: molecular genetic evidence of linkage to the Duchenne muscular dystrophy dilated gene at the Xp21 locus. Circulation 87:1854-1865, 1993
90. Urie PM, Billingham ME: Ultrastructural features of familial cardiomyopathy. Am J Cardiol 62:325-327, 1988
91. Valentine BA, Cummings JF, Cooper BJ: Development of Duchenne-type cardiomyopathy: morphologic studies in a canine model. Am J Pathol 135:671-678, 1989
92. Van Fleet J, Ferrans V: Pathology of the Cardiovascular System. Thomson's Special Veterinary Pathology, 2nd ed., pp. 175-208. Mosby, St. Louis, MO, 1995
93. Van Fleet JF, Ferrans VJ: Myocardial diseases of animals. Am J Pathol 124:98-178, 1986
94. Van Fleet JF, Ferrans VJ, Weirich WE: Pathological alterations in congestive cardiomyopathy of dogs. Am J Vet Res 42:416-424, 1981
95. Vollmar A: The prevalence of cardiomyopathy in the Irish Wolfhound: a clinical study of 500 dogs. J Am Anim Hosp Assoc 36:125-131, 2000
96. Vollmar AC, Fox PR, Meurs KM, Liu S-K: Dilated cardiomyopathy in juvenile Doberman pinscher dogs. J Vet Cardiol 5(1):23-27, 2005
97. Wright KN, Mehdirad AA, Giacobbe P, et al: Radiofrequency catheter ablation of atrioventricular accessory pathways in 3 dogs with subsequent resolution of tachycardia-induced cardiomyopathy. J Vet Intern Med 13:361-371, 1999
98. Wynne J, Braunwald E: The cardiomyopathies and myocarditides. In: Heart Disease: A Textbook of Cardiovascular Medicine, ed. Braunwald E, 5th ed., p. 1404. WB Saunders, Philadelphia, PA, 1997