Photoinduced Bergman cycloaromatization of imidazole-fused enediynes

Tetrahedron Letters

Volumn 46, Issue 8, 2005, Pages 1373-1375

  Zhao, Zhengrong ^a   Peacock, Justin G ^a   Gubler, Daniel A ^a   Peterson, Matt A ^a  

^a Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE DERIVATIVE; IMIDAZOLE DERIVATIVE; PLASMID DNA;

AROMATIZATION; ARTICLE; CHEMICAL REACTION; CONFORMATION; DNA CLEAVAGE; DNA SUPERCOILING; ENVIRONMENTAL TEMPERATURE; HYPOBARISM; IRRADIATION; LIGHT; SYNTHESIS;

EID: 13244253929     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.12.136     Document Type: Article

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30. 2] = 284.1314); UV (MeOH) max: 241 nm, min: 227 nm
31. 2] = 200.1314); UV (MeOH) max: 251, 258, 280, 290 nm, min: 234, 255, 267, 287 nm
32. Reaction mixtures were prepared by addition of supercoiled plasmid pGL3con DNA (2 μL of 1 μg/μL solution; 2 μg DNA), and TBE buffer (2.5 μL of 0.5× buffer), to appropriate stock solutions of compound 3 (20.5 μL of 1830, 183, 18.3, and 1.83 μM) to give a total volume of 25 μL. Samples were irradiated at room temperature with a 450 W mercury light source equipped with a Pyrex filter. The mixtures were analyzed on a 1.0% agarose gel at 80 V for 2 h
33. Densitometer readings showed non-background cleavage in lanes 2-6: lane 2 (upper/lower) = 0.3005; lane 3 (upper/lower) = 4.588; lane 4 (upper/lower) = 13.64; lane 5 (upper/lower) = 1.707; lane 6 (upper/lower) = 0.74011; lane 7 (upper/lower) = 0.5983; lane 8 (upper/lower) = 0.5729
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