Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: In vitro and in vivo selectivity

Journal of Pharmacology and Experimental Therapeutics

Volumn 312, Issue 2, 2005, Pages 780-785

  Damaj, M I ^a,c   Flood, P ^b   Ho, K K ^b   May, E L ^a   Martin, B R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; DEXTROMETHORPHAN; DEXTRORPHAN; DIZOCILPINE; LEVORPHANOL; MECAMYLAMINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE; NICOTINE; NICOTINIC RECEPTOR; OPIATE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FEMALE; HOT PLATE TEST; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; TAIL FLICK TEST; XENOPUS LAEVIS;

ANIMALS; DEXTROMETHORPHAN; DEXTRORPHAN; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; HEAT; MALE; MECAMYLAMINE; MICE; MICE, INBRED ICR; NEURONS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; OOCYTES; PAIN MEASUREMENT; REACTION TIME; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 13244249652     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.075093     Document Type: Article

References (28)

1. Aceto MD, Bagley RS, Dewey WL, Fu T-C, and Martin BR (1986) The spinal cord as a major site for the antinociceptive action of nicotine in the rat. Neuropharmacology 25:1031-1036.
2. Aceto MD, Martin BR, Uwaydah IM, May EL, Harris LS, Izazola-Conde C, Dewey WL, and Vincek WC (1979) Optically pure (+)-nicotine from (±)-nicotine and biological comparisons with (-)-nicotine. J Med Chem 22:174-177.
3. Bitner RS, Nikkel AL, Curzon P, Arneric SP, Bannon AW, and Decker MW (1998) Role of the nucleus raphe magnus in antinociception produced by ABT-594: immediate early gene responses possibly linked to neuronal nicotinic acetylcholine receptors on serotonergic neurons. J Neurosci 18:5426-5432.
4. Bitner RS, Nikkel AL, Curzon P, Donnelly-Roberts DL, Puttfarcken PS, Namovic M, Jacobs IC, Meyer MD, and Decker MW (2000) Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat. Brain Res 871:66-74.
5. Christensen M-K and Smith DF (1990) Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats. J Neural Transm 80:189-194.
6. Coates KM and Flood P (2001) Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant alpha 7 and alpha4 beta2 neuronal nicotinic receptors in Xenopus oocytes. Br J Pharmacol 134:871-879.
7. Damaj MI, Fei-Yin M, Dukat M, Glassco W, Glennon RA, and Martin BR (1998) Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice. J Pharmacol Exp Ther 284:1058-1065.
8. Damaj MI and Martin BR (1996) Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice. Eur J Pharmacol 300:51-57.
9. D'Amour FE and Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74-79.
10. Dewey WL, Harris LS, Howes JS, and Nuite JA (1970) The effect of various neurohormonal modulations on the activity of morphine and the narcotic antagonists in tail-flick and phenylquinone test. J Pharmacol Exp Ther 175:435-442.
11. 4, a novel subtype in the mammalian nervous system. J Neurosci 16:7892-7901.
12. Fossati A, Vimercati MG, Caputo R, and Valenti M (1995) Pharmacological profile of dextrorphan. Arzneim-Forsch/Drug Res 45:1188-1193.
13. 3H] dectrorphan binding in rat brain is localized to a non-competitive antagonist site of the activated N-methyl-D-aspartate receptor-cation channel. Mol Pharmacol 41:134-136.
14. Glick SD, Maisonneuve IM, Dickinson HA, and Kitchen BA (2001) Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine and nicotine self-administration in rats. Eur J Pharmacol 422:87-90.
15. 4 neuronal nicotinic receptors. J Pharmacol Exp Ther 293:962-967.
16. Iwamoto ET (1989) Antinociception after nicotine administration into the mesopontine tegmentum of rats: evidence for muscarinic actions. J Pharmacol Exp Ther 251:412-421.
17. Iwamoto ET (1991) Characterization of the antinociception induced by nicotine in the pedunculus tegmental nucleus and the nucleus raphe magnus. J Pharmacol Exp Ther 257:120-133.
18. Iwamoto ET and Marion L (1993) Adrenergic, serotonergic and cholinergic components of nicotinic antinociception in rats. J Pharmacol Exp Ther 265:777-789.
19. Khan IM, Yaksh TL, and Taylor P (1997) Epibatidine binding sites and activity in the spinal cord. Brain Res 753:269-282.
20. Klein M and Musacchio JM (1989) High affinity dextrometorphan binding sites in guinea pig brain. Effects of sigma ligands and other agents. J Pharmacol Exp Ther 251:207-215.
21. Mao J, Price DD, Lu J, Caruso FS, and Mayer DJ (1996) Oral administration of dextrometorphan prevents the development of morphine tolerance and dependence in rats. Pain 67:212-218.
22. Marubio LM, Arroyo-Jimenez MM, Cordero-Erausquin M, Léna C, LeNovère N, de Kerchove d'Exaerde A, Huchet M, Damaj MI, and Changeux J-P (1999) Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature (Lond) 398:805-810.
23. Murray TF and Leid ME (1984) Interaction of dextrorotary opioids with phencyclidine recognition sites in rat brain membranes. Life Sci 34:1899-1911.
24. Papke RL, Sanberg PR, and Shytle RD (2001) Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J Pharmacol Exp Ther 297:646-656.
25. Phan DV, Doda M, Bite A, and György L (1973) Antinociceptive activity of nicotine. Acta Physiol Acad Sci Hung 44:85-93.
26. Rao TS, Correa LD, Reid RT, and Lloyd GK (1996) Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay. Neuropharmacology 35:393-405.
27. Tallarida HJ and Murray RB (1987) Manual of Pharmacological Calculations with Computer Programs. Springer-Verlag New York Inc., New York.
28. Wu D, Otton SV, Kalow W, and Sellers EM (1995) Effects of route of administration on dextromethorphan pharmacokinetics and behavioral response in the rat. J Pharmacol Exp Ther 274:1431-1437.