Improvement of colonic healing by preoperative rectal irrigation with short-chain fatty acids in rats given radiotherapy

Diseases of the Colon and Rectum

Volumn 47, Issue 12, 2004, Pages 2184-2194

  Terzi, Cem ^a,b   Sevinç, Ali Ibrahim ^a   Koçdor, Hilal ^a   Oktay, Gülgün ^a   Alanyali, Hilmi ^a   Küpelioǧlu, Ali ^a   Ergör, Gül ^a   Füzün, Mehmet ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Collagen concentrations; Colonic anastomosis; Radiotherapy; Short chain fatty acids

Indexed keywords

COLLAGEN; SHORT CHAIN FATTY ACID; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; CHEMICAL PARAMETERS; COLON; COLON ANASTOMOSIS; COLON SURGERY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EPITHELIUM; GRANULATION TISSUE; HEALING; HISTOLOGY; IRRADIATION; LAVAGE; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PREOPERATIVE CARE; PREOPERATIVE RADIOTHERAPY; PRESSURE MEASUREMENT; RADIATION DOSE; RAT;

ANASTOMOSIS, SURGICAL; ANIMALS; COLECTOMY; COLLAGEN; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENEMA; FATTY ACIDS, VOLATILE; GRANULATION TISSUE; IRRIGATION; MALE; NEOADJUVANT THERAPY; PREOPERATIVE CARE; RADIOTHERAPY, ADJUVANT; RATS; RATS, WISTAR; RECTUM; SURGICAL WOUND DEHISCENCE; SURGICAL WOUND INFECTION; TENSILE STRENGTH; TIME FACTORS; WEIGHT LOSS; WOUND HEALING;

EID: 13144283669     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10350-004-0724-7     Document Type: Article

References (37)

1. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 1997;336:980-7.
2. Camma C, Giunta M, Fiorica F, Pagliaro L, Craxi A, Cottone M. Preoperative radiotherapy for resectable rectal cancer: a meta-analysis. JAMA 2000;284:1008-15.
3. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001; 345:638-46.
4. Dahlberg M, Glimelius B, Graf W, Pahlman L. Preoperative irradiation affects functional results after surgery for rectal cancer: results from a randomized study. Dis Colon Rectum 1998;41:543-51.
5. Meyerson RJ, Genovesi D, Lockett MA, et al. Five fractions of preoperative radiotherapy for selected cases of rectal carcinoma: long-term tumour control and tolerance to treatment. Int J Radiat Oncol Biol Phys 1999;43: 537-43.
6. Kuzu MA, Kuzu J, Köksoy C, et al. Histological evaluation of colonic anastomotic healing in the rat following preoperative 5-fluorouracil, fractionated irradiation and combined treatment. Int J Colorectal Dis 1998;13:235-40.
7. Aguilar-Nascimento JE, Mathie RT, Man WK, Williamson CN. Enhanced intra-anastomotic healing by operative lavage with nutrient solutions in experimental left-sided colonic obstruction. Br J Surg 1995;82:461-4.
8. Aguilar-Nascimento JE, Joaquim PD, Mathie RT, Williamson RC. Effect of intraoperative nutritional solutions on perianastomotic colonic mucosa in experimental large bowel obstruction. Dig Dis Sci 1997;42:2581-4.
9. Topçu Ö, Karadayi K, Kuzu MA, Ulukent S, Erkek B, Alaçayir İ. Enteral and intraluminal short-chain fatty acids improves ischemic left colonic anastomosis healing in the rat. Int J Colorectal Dis 2002;17:171-6.
10. Cummings JH. Short chain fatty acids in the human colon. Gut 1981;22:763-79.
11. Sakata T, Von Englehardt W. Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in rat large intestine. Comp Biochem Physiol 1983;74A:459-62.
12. Carrico TJ, Merhof AI, Cohen IK. Biology of wound healing. Surg Clin North Am 1984;64:721-33.
13. Kvietys PR, Granger DN. Effect of volatile fatty acids on blood flow and oxygen uptake by the dog colon. Gastroenterology 1981;80:962-9.
14. Weiber S, Jiborn H, Zederfeldt B. Preoperative irradiation and colonic healing. Eur J Surg 1994;160:47-51.
15. Knightly JJ, Agostino D, Cliffton EE. The effect of fibrinolysin and heparin on the formation of peritoneal adhesions. Surgery 1902;52:250-8.
16. De Roy van Zuidewein DB, Schillings PH, Wobbes T, De Boer HH. Histologic evaluation of wound healing in experimental intestinal anastomoses: effects of antineoplastic agents. Int J Exp Pathol 1992;73:465-84.
17. Irvin TT, Hunt TK. Effect of malnutrition on colonic healing. Ann Surg 1974;180:765-72.
18. Reddy GK, Enweka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996;29:225-9.
19. Stockholm Rectal Cancer Study Group. Short-term preoperative radiotherapy for adenocarcinoma of the rectum. Am J Clin Oncol 1987;10:369-75.
20. Pahlman L, Glimelius B. Pre- or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Ann Surg 1990;211:187-95.
21. Cronin K, Jackson DS, Dunphy JE. Changing bursting strength and collagen content of the healing colon. Surg Gynecol Obstet 1968;126:747-53.
22. Hermann JB, Woodward SC, Pulaski EJ. Healing of colonic anastomoses in the rat. Surg Gynecol Obstet 1964; 119:169-75.
23. Ahrendt MG, Gardner K, Barbul A. Loss of colonic structural collagen impairs healing during intra-abdominal sepsis. Arch Surg 1994;129:1179-83.
24. Kiyama T, Onda M, Tokunaga A, Yoshiyuki T, Barbul A. Effect of early postoperative feeding on the healing of colonic anastomoses in the presence of intra-abdominal sepsis in rats. Dis Colon Rectum 2000;43:S54-8.
25. Hendriks T, Mastboom WJ. Healing of experimental intestinal anastomoses: parameters for repair. Dis Colon Rectum 1990;33:891-901.
26. Reiser K, Mc Cormick RJ, Rucker RB. Enzymatic and non-enzymatic cross-linking of collagen and elastin. FASEB J 1992;6:2439-49.
27. Houdart R, Lavergne A, Galian A, Hautefeuille P. Histopathological evaluation of single layer end-to-end intestinal anastomoses- a study of 210 colonic anastomoses in the rat, from the 2nd to 180th days. Gastroenterol Clin Biol 1983;7:465-73.
28. Kuzu MA, Koksoy C, Akyol FH, Uzal D, Kale T, Demirpence E. Effects of preoperative fractioned irradiation on left colonic anastomoses in the rat. Dis Colon Rectum 1998;41:370-6.
29. Biert J, Hoogenbout J, Wobbes T, Hendriks T. High-dose preoperative irradiation without detrimental effect on early repair of anastomoses in the colon of the rat. Radiat Res 1997;147:302-8.
30. Ceelen W, El Malt M, Cardon A, Berreveat F, De Neve W, Pattyn P. Influence of preoperative high-dose radiotherapy on postoperative outcome and colonic anastomotic healing: experimental study in the rat. Dis Colon Rectum 2001;44:717-21.
31. Weiber S, Bjelkengren G, Rank F, Jiborn H, Zedefeldt B. Radiation effects in the colon. An experimental study in the rat. Acta Oncol 1993;32:565-9.
32. Windmueller HG, Spaeth AE. Identification of ketene bodies and glutamine as the major respiratory fuels in vivo for post absorptive rat small intestine. J Biol Chem 1978;253:69-76.
33. Roediger WE. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 1980; 21:793-8.
34. Rolandelli RH, Koruda MJ, Settle G, Rombeau JL. Effects of intraluminal infusion of short- chain fatty acids on the healing of colonic anastomosis in the rat. Surgery 1986; 100:198-204.
35. Weiber S, Graf W, Glimelius B, Jiborn H, Pahlman L, Zederfeldt B. Experimental colonic healing in relation to timing of 5-FU therapy. Br J Surg 1984;81:1677-80.
36. Milsom JW, Senagore A, Walshaw RK, et al. Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow. Surg Res 1992;53:464-9.
37. Wilfried F, Wobbes T, Hoogenhout J, De Man BM, Huyben KM, Hendriks T. Intraoperative irradiation delays anastomotic repair in rat colon. Am J Surg 1995;170: 256-61.