Rejection mechanisms of isolated porcine pancreatic islets transplanted into rodents;ABSTOSSUNGSREAKTIONEN BEI DER TIEREXPERIMENTELLEN XENOGENEN TRANSPLANTATION VON ISOLIERTEN LANGERHANSSCHEN INSELN DES SCHWEINS

Zentralblatt fur Chirurgie

Volumn 123, Issue 7, 1998, Pages 823-829

  Jahr, H ^a   Brandhorst, D ^a   Brandhorst, H ^a   Brendel, M ^a   Eckhardt, T ^a   El Ouaghlidi, A ^a   Hussmann B ^a   Lau, D ^a   Nahidi, F ^a   Wacker, T ^a   Zwolinski, A ^a   Bretzel, R G ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Mice; Pancreatic islet; Pig; Rat; Rejection; Xenogeneic transplantation

Indexed keywords

NITRIC OXIDE;

ANIMAL MODEL; CELL TRANSPLANTATION; COMPLEMENT ACTIVATION; GRAFT REJECTION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; RAT; REVIEW; SWINE; XENOTRANSPLANTATION;

ADULT; ANIMALS; COMPLEMENT ACTIVATION; FETAL TISSUE TRANSPLANTATION; GRAFT REJECTION; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, NUDE; RATS; SPECIES SPECIFICITY; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 13144266684     PISSN: 0044409X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Albina JE, Henry WL (1991) Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway. J Surg Res 50: 403-409
2. Albina JE (1995) On the expression of nitric oxide synthase by human macrophages. Why no NO? J Leukocyte Biol 58: 643-649
3. Auchincloss H (1988) Xenogeneic transplantation. A review. Transplantation 46: 1-20
4. Bach FH, Ferran C, Soares M, Wrighton CJ, Anrather J, Winkler H, Robson SC, Hancock WW (1997) Modification of vascular re sponses in xenotransplantation: inflammation and apoptosis. Nature Med 3: 944-948
5. Bach FH, Robson SC, Ferran C, Winkler H, Millan MT, Stuhlmeier KM, Vanhove B, Blakley ML, van der Werf WJ, Hofer E, De Martin R, Hancock WW (1994) Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev 141: 5-30
6. Benda B, Korsgren O (1997) Xenograft rejection of fetal porcine islet-like cell cluster (ICC) in normal. T cell receptor (TCR)ß-, TCRδ-, TCRβxδ-, Perforin-, or Granzyme B-deficient mice. Acta Diabetologica 34: 141 (Abstract)
7. Brandhorst D, Brandhorst H, Zwolinski A, Nahidi F, Jahr H, Bretzel RG (1997) Primary nonfunction is not caused by accelerated rejection after pig to rat adult islet transplantation. Acta Diabetologica 34: 154 (Abstract)
8. Braun K, Führer K, Noack U, Jahr H (1994) In-vivo Testung isolierter Langerhansscher Inseln des Schweins durch Xenotransplantation in diabetische C57B1/6-Mause. Diab Stoffw 3: 152 (Abstract)
9. Braun K, Noack U, Führer K, Jahr H (1994) Enhanced nitrogen oxide-synthesis in mouse macrophages after partial hepatectomy may cause primary nonfunction of xenotransplanted pig islets. Horm Metab Res 26: 62
10. Braun K, Noack U, Fuhrer, K, Jahr H (1996) Induction of nitric oxide synthesis in rodent macrophages after partial hepatectomy. In: Faist E (Hrsg): Immune Consequences of Trauma Shock and Sepsis - Mechanisms and Therapeutic Approaches. S 673-677. Lengerich: Pabst Science Publishers
11. Brayman KL, Morel P, Field J, Llovsras JJ, Leventhal J, Nakhleh R, Jessurun J, Platt J, Matas AJ, Najarian JS, Cores PF, Sutherland DER (1992) A comparison of mice and rats as recipients for canine islet xenografts. Transplant Proc 24: 651-652
12. Carty SE, Carroll PB, Rilo H, Brumfield A, Ricordi C (1994) Primary nonfunction of human pancreatic islet xenografts is murine strain dependent. Transplant Proc 26: 780
13. Eizink DL, Pipeleers DG, Ling Z, Welsh N, Hellerström C, Andersson A (1994) Major species differences between humans and rodents in the susceptibility to pancreatic ß-cell injury. Proc Natl Acad Sci 91: 9253-9256
14. de Villa VH, Cienfuegos JA, Pardo F, Hernandez JL, Gonzalez J, Torramadé J, Regueira F, Montuenga L (1992) Gamma irradiation and donor antigen injection prior to xenografting of pig islets into the thymus of diabetic rats. Transplant Proc 24: 2851-2852
15. Falqui L, Finke EH, Carel JC, Scharp DW, Lacy PE (1991) Marked prolongation of human islet xenograft survival (human-to-mouse) by low-temperature culture and temporary immunosuppression with human and mouse anti-lymphocyte sera. Transplantation 51: 1322-1324
16. Finke E, Marchetti P, Swanson C, Me Lear M, Olack B, Scharp D, Lacy P (1991) Large scale isolation, function, and transplantation of islets of Langerhans from the adult pig pancreas. Transplant Proc 23: 772-773
17. Goldstein IM (1992) Complement: Biologically active products. In: Gallin JI, Goldstein IM, Snyderman R (Hrsg): Inflammation-Basic Principles and Clinical Correlates. S 63-80. New York: Raven Press
18. Groth CG, Korgsen O, Tibell A, Möller E, Bolinder J, Ostman J, Reinholt FP, Hellerstrom C, Andersson A (1994) Transplantation of fetal porcine pancreas to diabetic patients: Biochemical and histological evidence for graft survial. Lancet 344: 1402- 1404
19. Haas W, Pereira P, Tonegawa S (1993) g/d cells. Annu Rev Immunol 11: 637-685
20. Hammer C (1993) Aspekte der xenogenen Herztransplantation. Z Tx Med S. 147-155
21. Hering BJ (1992) Islet xenotransplantation. In: Ricordi C (Hrsg): Pancreatic islet cell transplantation. S 313-335. Austin: R G Landes Company
22. Hering BJ, Brendel MD, Schultz, AO, Schultz B, Bretzel RG (1996) International Islet Transplant Registry. Justus-Liebig-Umversität Giessen, Newsletter No. 7
23. Hill RS, Dang T, Geil S, Ha L, Hager S, Hagre O, Lamberti F, Mundwiler K, Nichols J, Young C, Yu X, Scharp D (1997) PEG encapsulated porcine islet correction of diabetic Sprague-Dawley rats. Acta Diabetologica 34: 159(Abstract)
24. Inoue K, Gu YJ, Shinohara S, Kogire M, Mitsuo M, Nakai I, Hayashi, H, Kaij H, Uchida K, Maetani S, Ikada Y, Tobe T (1992) Expertmental Xenotransplantation of isolated adult pig islets. Transplant Proc 24: 658
25. Inverardi L, Clissi B, Stolzer AL, Bender JR, Sandrin MS, Pardi R (1997) Human natural killer lymphocytes directly recognize evolutionary conserved oligosaccaride ligands expressed by xenogeneic tissues. Transplantation 63: 1318-1330
26. Jäger C, Hering BJ, Dyrberg T, Federlin K, Bretzel RG (1996) Islet cell antibodies and glutamic acid decarboxylase antibodies in patients with insulin-dependent diabets mellitus undergoing kidney and islet-after-kidney transplantation. Transplantation 62: 424-426
27. Jindal RM, Soltys K, Yost F, Beer E, Tepper MA, Cho SI (1994) Xenotransplantation of pig pancreatic islets using 15-deoxyspergualin monotherapy. Transplant Proc 26: 1108-1109
28. Jahr H, Brendel M, Brandhorst D, Brandhorst H, Bretzel RG (1998) Hyperakute Rejektion - eine Barriere für die Transplantation von Langerhansschen Inseln des Schweins bei Typ-I-Diabetikern? Transplantationsmedizin 10: 41-47
29. Jahr H, Bretzel R, Wacker T, Weinand S, Brandhorst H, Brandhorst D, Lau D, Hering BJ, Federlin K (1995) Toxic effects of super-oxide, hydrogen peroxide, and nitric oxide on human and pig islets. Transplant Proc 27: 3220-3221
30. Jahr H, Noack U, Braun K (1996) Complement activation enhances nitrogen oxide (NO) synthesis in rat macrophages. In: Faist E (Hrsg): Immune Consequences of Trauma Shock and Sepsis-Mechanisms and Therapeutic Approaches. S 191-193. Lengerich: Pabst Science Publishers
31. Jahr H, Brandhorst D, Brandhorst H, Bretzel RG (1998) Co-stimulation of lectin-incubated human T-cells by allogeneic and xenogeneic islets, Horm Metab Res 30: A15
32. Janjic D, Wollheim CB (1992) Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 35: 482-485
33. Kaufman DB, Platt JL, Rabe FL, Dunn DL, Bach FH, Sutherland DER (1990) Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts. J Exp Med 172: 291-302
34. Koopman G, Reutelingsperger CPM, Kuijten GAM, Keehnen RMJ, Pals ST, van Oers MHJ (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84: 1415-1420
35. Kowalski L, Falqui L, Lacy PE, Scharp DW (1991) Production of marked prolongation of survival of canine islet xenografts in mice by antilymphocyte sera and L3T4 antibody. Transplantation 52: 1094-1097
36. Lau D, Hering BJ, El-Ouaghlidi A, Jahr H, Brandhorst H, Brandhorst D, Vietzke R, Federlin K, Bretzel RG, Isokinetic gradient centrifugaton prolongs survival of pig islets xenografted into mice. J Molec Med. im Druck
37. Lenschow DJ, Zeng Y, Thistlechwaite JR, Montag A, Brady W, Gibson MG, Linsey PS, Bluestone JA (1992) Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Scinence 257: 789-792
38. Liu X, Federlin F, Bretzel RG, Hering BJ, Brendel MD (1991) Persistent reversal of diabetes by transplantation of fetal pig proislets into nude mice. Diabetes 40: 858-866
39. Maki T, O'Neil JJ, Porter J, Mullon CJP, Solomon BA, Monaco AP (1996) Porcine islets for Xenotransplantation. Transplantation 62: 136-138
40. Mandel TE, Koulmanda M, Loudovaris T, Bacelj A (1998) Islet grafts in NOD mice: a comparision of iso-, allo, and pig xenografts. Transplant Proc 21: 3813-3814
41. Marchetti P, Scharp DW, Finke EH, Swanson CJ, Olack BJ, Gerasimidi-Vazeou D, Giannarelli R, Navalesi R, Lacy PE (1996) Prolonged survival of discordant porcine islet xenografts. Transplantation 61: 1100-1102
42. McKenzie IFC, Koulmanda M, Mandel TE, Xing PX, Sandrin MS (1995) Pig-to-human xenotransplantation: the expression of Galα(1-3)Gal epitopes on pig islet cells. Xenotransplantation 2: 1-7
43. Mirenda V, Mauff BL, Cassard A, Huvelin J-M, Boeffard F, Faivre A, Soulillou J-P, Anegon I (1997) Intact pig pancreatic islet function in the presence of human xenoreactive natural antibody binding and complement activation. Transplantation 63: 1452-1462
44. Mirenda V, Sigalla J, Fiche M, Thibaudeau K, Huvelin JM, Soulillou JP, Le Mauff B (1997) Pig pancreatic islet xenografts in a B-cell deficient mouse model. Transplant Proc 29: 762-763
45. Moses RD, Winn HJ, Auchincloss H (1992) Evidence that multiple defects in cell-surface molecule interactions across species differences are responsible for diminished xenogeneic T cell responses. Transplantation 53: 203-209
46. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63
47. Okumura C, Suto R, Furukawa K, Ahmed SS, Furukawa K, Nakayama E, Fujii T, Shiku (1995) Induction of murine γδT cells cytotoxic for xenogeneic rat cells. J Immunol 154: 1114-1123
48. Parker W, Saadi S, Lin SS, Holzknecht ZE, Bustos M, Platt JL (1996) Transplantation of discordant xenografts: a challenge revisited. Immunol Today 17: 373-378
49. Patience C, Takeuchi Y, Weiss RA (1997) Infection of human cells by an endogenous retrovirus of pigs. Nature Med 3; 282-286
50. Pittman K, Henretta J, McFadden T, Thomas J, Thomas FT (1994) Prevention of primary nonfuncrtion of xenografted islets. Transplant Proc 26: 1141-1412
51. Pittman K, Thomas F, McFadden T, Haisch C, Thomas J (1993) Reduction of primary nonfunction of pancreas islet transplants with antithymocyte globulin agents, desoxyspergualin, and spelenectomy. Transplant Proc 25: 386-387
52. Platt JL (1996) Xenotransplantation: recent progress and current perspectives. Curr Opinion Immunol 8: 721-728
53. Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Schulz R, Lakey JRT, Warnock GL, Rajotte RV (1994) Human pancreatic islet β-cell destruction is independent of nitric oxide production. J Clin Endocrinol Metab 79: 1058-1062
54. Ricordi C, Lacy PE (1987) Renal subcapsular xenotransplantation of purified porcine islets. Transplantation 44: 721-723
55. Ricordi C, Lacy PE, Sterbenz K, Davie JM (1987) Low-temperature culture of human islets or in vivo treatment with L3T4 antibody produces a marked prolongation of islet human-to-mouse xenograft survival. Proc Natl Acad Sci USA 84: 8080-8084
56. Ricordi C, Socci C, Davalli AM, Staudacher C, Baro P, Vertova A, Sassi I, Gavazzi F, Pozza G, Di Charlo V (1990) Isolation of the elusive pig islet. Surgery 107: 688-694
57. Sassi F, Hugo F, Muhly M, Khaled A, Bhakdi S (1987) A reason for the cytolytic inefficiency of murine serum. Immunology 62: 145-147
58. Satake M, Korsgren O, Ridderstad A, Karlsson-Parra A, Wallgren AC, Möller E (1994) Immunological characteristics of islet cell xe notransplantation in humans and rodents. Immunol Review 141: 191-211
59. Stegall MD, Lafferty KJ, Kam I, Gill RG (1996) Evidence of recurrent autoimmunity in human allogeneic islet transplantation. Transplantation 61: 1272-1274
60. Stevens RB, Ansite JD, Mills CD, Lokeh A, Rossini TJ, Saxena M, Brown RR, Sutherland DER (1996) Nitric oxide mediates early dysfunction of rat and mouse islets after transplantation. Transplantation 61: 1740-1749
61. Sung RS, Fiedor PS, Yaron I, Zakheim AR, Quadracci KM, Goodman ER, Hardy MA (1996) Survival of human islet xenografts irradiated with ultraviolet B in diabetic rats. Transplant Proc 28: 839
62. Stuehr DJ, Marletta MA (1987) Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines. or interferon-γ. J Immunol 139: 518-525
63. Troppmann C, Gruessner AC, Papalois BE, Nakhleh RE, Gruessner RWG (1997) Discordant xenoislets from a large animal donor undergo accelerated graft failure rather than hyperacute rejection: Impact of immunosuppression, islet mass, and transplant site on early outcome. Surgery 121: 194-205
64. Tze WJ, Tai J, Cheung S (1989) Xenotransplamation of human islets in diabetic rats. Transplant Proc 21: 2741-2743
65. Tze WJ, Tai J, Cheung SSC (1992) Transplantation of discordant pig islet xenografts in diabetic rats. Diabetes Res Clin Pract 15: 197-204
66. Tze WJ, Cheung SSC, Tai J (1994) In vivo studies of UV-B-irradiated adult pig islets in diabetic mice. Transplant Proc 26: 3487-3488
67. Vaughan HA, Loveland BE, Sandrin MS (1994) Gala(1,3)Gal is the major xenoepitope expressed on pig endothelial cells recognized by naturally occurring cytotoxic human antibodies. Transplantation 58: 879-882
68. Vercellotti GM, Platt JL, Bach FH, Dalmasso AP (1991) Neutrophil adhesion to xenogeneic endothelium via iC3b. J Immunol 146: 730-734
69. Wacks HJ, Kühn F, Jahr H, Gütte N, Wachlin G, Hahn HJ, Wolff H (1992) Viability testing of isolated endocrine pancreatic tissue by a rapid colorimetric assay. Z Transplantationsmedizin 4: 1-4
70. Warnock GL, Kneteman NM, Rajotte RV (1990) Effect of diabetes on the function of transplanted human islets of Langerhans. Transplant Proc 22: 804-805
71. Weber CJ, Hardy MA, Rivera S, Bailey-Braxton D, Michler R, Thomas W, Chabot J, Pi-Sunyer FX, Wood M, Reetsma K (1986) Diabetic mouse bioassay for functional and immunologic human and primate islet xenograft survival. Transplant Proc 18: 823-828
72. White DJG, Calne RY (1996) Xenotransplantation. Chirurg 67: 324-330
73. Zeng Y, Gage A, Montag A, Rothlein R, Thistlethwaite JR, Bluestone JA (1994) Inhibition of transplant rejection, by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-antibodies. Transplantation 58 681-689