Intact pig pancreatic islet function in the presence of human xenoreactive natural antibody binding and complement activation

Transplantation

Volumn 63, Issue 10, 1997, Pages 1452-1462

  Mirenda, Vincenzo ^a   Le Mauff, Brigitte ^a   Cassard, Armelle ^a   Huvelin, Jean Michel ^a   Boeffard, Françoise ^a   Faivre, Alain ^a   Soulillou, Jean Paul ^a   Anegon, Ignacio ^a,b  

^a Inst Transplant/Rech Transplant   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; EPITOPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CAPILLARY ENDOTHELIUM; CELL VIABILITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOLYSIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; GRAFT REJECTION; HUMAN; IMMUNOHISTOLOGY; MOUSE; NONHUMAN; OPSONIZATION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; SERUM; SWINE; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES; ANTIBODY FORMATION; BINDING SITES, ANTIBODY; CELLS, CULTURED; COMPLEMENT ACTIVATION; DISACCHARIDES; EPITOPES; FEMALE; GALACTOSE; HUMANS; ISLETS OF LANGERHANS; LECTINS; SWINE; TISSUE PRESERVATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0031008954     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199705270-00015     Document Type: Article

References (26)

1. Gores PF. New perspectives on islet xenotransplantation. Xeno 1995; 3: 39.
2. Cooper DKC, Ye Y, Rolf LLJ, et al. The pig as a potential organ donor for man. In: Cooper DKC, Kemp E, Reemtsma K, et al., eds. Xenotransplantation. Heidelberg: Springer-Verlag, 1991: 481.
3. Sachs DH, Bach FH. Immunology of xenograft rejection. Hum Immunol 1990; 28: 245.
4. Sandrin MS, Vaughan HA, McKenzie FC. Identification of Gal(a 1,3)Gal as the major epitope for pig-to-human vascularized xenografts. Transpl Rev 1994; 8(3): 134.
5. Oriol R, Yong Y, Koren E, Cooper DKC. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-human organ xenotransplantation. Transplantation 1993; 56: 1433.
6. McKenzie IFC, Koulmanda M, Mandel TE, et al. Pig-to-human xenotransplantation: the expression of Galα(1-3)Gal epitopes on pig islet cells. Xenotransplantation 1995; 2: 1.
7. Groth CG, Korsgren O, Tibell A, et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 1994; 344: 1402.
8. Satake M, Kumagai-Braesch M, Korsgren O, et al. Characterization of humoral human anti-porcine xenoreactivity. Clin Transplant 1993; 7: 281.
9. Ricordi C, Socci C, Davalli AM, et al. Isolation of the elusive islet. Surgery 1990; 107: 688.
10. Ricordi C, Gray DWR, Hering BJ, et al. Islet isolation assessment in man and large animals. Acta Diabetol Lat 1990; 27: 185.
11. Latif ZA, Noel J, Alejandro R. A simple method of staining fresh and cultured islets. Transplantation 1988; 45: 827.
12. Hamelmann W, Gray DWR, Cairns TDJ, et al. Immediate destruction of xenogeneic islets in a primate model. Transplantation 1994; 58: 1109.
13. Thibaudeau K, Borche L, Soulillou JP, et al. Characterization of porcine platelet glycoprotein recognized by human natural "anti-Gal" antibodies. Blood 1996; 87: 4636.
14. Marchetti P, Finke EH, Swanson C, et al. The potential of porcine islet xenotransplantation in the therapy of diabetes. Diab Nutr Metab 1992; 5 (suppl 1): 151.
15. Marchetti P, Giannarelli R, Cosimi S, et al. Massive isolation, morphological and functional characterization, and xenotransplantation of bovine pancreatic islets. Diabetes 1995; 44: 375.
16. McKenzie IFC, Xing P-X, Vaughan HA, et al. Distribution of the major xenoantigen Gal(α 1,3)Gal for pig to human xenograft. Transplant Immunol 1994; 2: 81.
17. Bray J, Lemieux RU, McPherson TA. Use of a synthetic hapten in the demonstration of the Thomsen-Friedenreich (T) antigen on neuraminidase-treated human red blood cells and lymphocytes. J Immunol 1981; 126: 1966.
18. Rydberg L, Cairns TDH, Groth CG, et al. Specificities of human IgM and IgG anticarbohydrate xenoantibodies found in the sera of diabetic patients grafted with fetal pig islets. Xenotransplantation 1994; 1: 69.
19. Shaapherder AFM, Daha MR, van der Woude FJ. IgM, IgG, and IgA antibodies in human sera directed against porcine islets of Langerhans. Transplantation 1993; 56: 739.
20. Inverardi L, Pardi R. Humoral and cellular recognition of discordant xenogeneic Langerhans islets. Tranplant Proc 1994; 26: 1034.
21. Shaapherder AFM, Wolvekamp MCJ, te Bulte M-TJW, et al. Porcine islet cells of Langerhans are destroyed by human complement and not by antibody-dependent cell-mediated mechanisms. Transplantation 1996; 62: 29.
22. Braun K, Jahr H. Organ-specific natural antibodies in pig islet xenotransplantation. Transplant Proc 1992; 24: 2979.
23. Kin T, Nakajima Y, Kanehiro H, et al. Influence of complement in human serum on isolated porcine islets. Transplant Proc 1996; 28: 836.
24. Vercellotti GM, Platt JL, Bach FH, et al. Neutrophil adhesion to xenogeneic endothelium via iC3b. J Immunol 1991; 146: 730.
25. Tze WJ, Tai J, Cheung SC, et al. A diabetic rabbit model for pig islet xenotransplantation. Transplantation 1993; 56: 1348.
26. Mandel TE, Koulmanda M, Kovarik J, et al. Transplantation of organ cultured fetal pig pancreas in non-obese diabetic (NOD) mice and primates (Macaca fascicularis). Xenotransplantation 1995; 2: 128.