Blood folic acid and vitamin B12 in relation to neural tube defects

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 103, Issue 4, 1996, Pages 319-324

  Wald, N J ^a   Hackshaw, A K ^a   Stone, R ^a   Sourial, Nefertiti A ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DRUG EFFICACY; FEMALE; FETUS; FOLIC ACID DEFICIENCY; HUMAN; NEURAL TUBE DEFECT; PREGNANCY DISORDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

FEMALE; FOLIC ACID; HUMANS; NEURAL TUBE DEFECTS; PREGNANCY; RISK FACTORS; VITAMIN B 12;

EID: 0030012734     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1996.tb09735.x     Document Type: Article

References (16)

1. MRC Vitamin Study Research Group. Prepared by N. Wald with assistance from J. Sneddon, J. Densem, C. Frost and R. Stone. Prevention of neural tube defects: Results of the MRC Vitamin Study. Lancet 1991; 338: 132-137.
2. Schorah CJ, Smithells RW, Scott J. Vitamin B12 and anencephaly. Lancet 1980; i: 880.
3. Anderson BB, Sourial NA. The assay of serum cobalamin by Euglene gracilis. In: Hall, CA, ed. Methods in Haematology: The Cobalumins. Edinburgh : Churchill Livingstone, 1983: 51-64.
4. Wald N. Folic acid and neural tube defects: the current evidence and implications for prevention. In: Neural Tube Defecfs, CIBA Foundation Symposium 181. London : Wiley, 1994.
5. Wald N. Folic acid and the prevention of neural tube defects. Maternal nutrition and pregnancy outcome. Ann NY Acad Sci 1993; 678: 112-129.
6. Kirke PN, Molloy AM, Daly LE et al. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993; 86: 703-708.
7. Yates JRW, Ferguson, Smith MA, Shenkin A et al. Is disorder folate metabolism the basis for the genetic predisposition to neural tube defects Clin Genet 1987; 31: 279-287.
8. Hall MH. Folates and the fetus. Lancet 1977; i: 648-649.
9. 12 concentrations in pregnancies associated with neural tube defects. Arch Dis Child 1985; 60: 660-665.
10. Smithells RW, Sheppard S, Schorah CJ. Vitamin deficiencies and neural tube defects. Arch Dis Child 1976; 51: 944-949.
11. Mills JL, Tuomilehto Y, Yu KE et al. Maternal vitamin levels during pregnancies producing infants with neural tube defects. J Paediatr 1992; 120: 863-871.
12. Economides DL, Ferguson J, MacKenzie IZ et al. Folate and vitamin B12 concentrations in maternal and fetal blood and amniotic fluid in second trimester pregnancies complicated by neural tube defects. Br J Obstet Gynaecol 1992; 99: 22-25.
13. Emery AEH, Timson J, Watson-Williams EJ. Pathogenesis of spina bifida. Lancet 1969; ii: 909-910.
14. Bower C, Stanley FJ. Dietary folate as a risk factor for neural tube defects: Evidence from a case-control study in Western Australia. Med J Aust 1989; 150: 613-618.
15. Wild J, Schorah CJ, Sheldon TA, Smithells EW. Investigation of factors influencing folate status in women who have had a neural tube defect affected infant. Br J Obstet Gynaecol 1993; 100: 546-549.
16. Laurence KM, James N, Miller MH, Tennant GB, Campbell H. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural tube defects. BMJ 1981; 282: 1509-1511.