Association and linkage analysis of RGS4 polymorphisms with schizophrenia and bipolar disorder in Brazil

Genes, Brain and Behavior

Volumn 4, Issue 1, 2005, Pages 45-50

  Cordeiro, Q ^a   Talkowski, M E ^b   Chowdari, K V ^b   Wood, J ^b   Nimgaonkar, V ^b   Vallada, H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Association; Bipolar disorder; Genetic; RGS4; Schizophrenia; TDT

Indexed keywords

RGS PROTEIN; RGS4 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIPOLAR DISORDER; BRAZIL; CASE CONTROL STUDY; CONTROLLED STUDY; ETHNIC DIFFERENCE; FAMILY STUDY; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC RISK; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BIPOLAR DISORDER; BRAZIL; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; RGS PROTEINS; SCHIZOPHRENIA;

EID: 12944316462     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1601-183x.2004.00096.x     Document Type: Article

References (22)

1. Brzustowicz, L.M., Hodgkinson, K.A., Chow, E.W., Honer, W.G. & Basset, A.S. (2000) Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288, 678-682.
2. Chen, X. & Kwok, P.Y. (1997) Template-directed dye-terminator incorporation (TDI) assay: a homogeneous DNA diagnostic method based on fluorescence resonance energy transfer. Nucleic Acids Res 25, 347-353.
3. Chowdari, K.V., Mirnics, K., Semwal, P., Wood, J., Lawrence, E., Bhatia, T., Deshpande, S.N., Ferrell, R.E., Middleton, F.A., Devlin, B., Levitt, P., Lewis, D.A. & Nimgaonkar, V.L. (2002) Association and linkage analyses of RGS4 polymorphism in schizophrenia. Hum Mol Genet 11, 1373-1380.
4. Clayton, D. (1999) A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65, 1170-1177.
5. Clayton, D. & Jones, H. (1999) Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet 65, 1161-1169.
6. De Vries, L., Zheng, B., Fischer, T., Elenko, E. & Farquhar, M.G. (2000) The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol 40, 235-271.
7. Druey, K.M., Blumer, K.J., Kang, V.H. & Kehrl, J.H. (1996) Inhibition of G-protein mediated MAP kinase activation by a new mammalian gene family. Nature 379, 742-746.
8. Fallin, D., Cohen, A., Essioux, L., Chumakov, I., Blumenfeld, M., Cohen, D. & Schork, N.J. (2001) Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Res 11, 143-151.
9. Gould, T.D. & Manji, H.K. (2002) Signaling networks in the pathophysiology and treatment of mood disorders. J Psychosom Res 53, 687-697.
10. Gurling, H.M., Kalsi, G., Brynjolfson, J., Sigmundsson, T., Sherrington, R., Mankoo, B.S., Read, T., Murphy, P., Blaveri, E., McQuillin, A., Petursson, H. & Curtis, D. (2001) Genome-wide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 68, 661-673.
11. Harrison, P.J. & Owen, M.J. (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361, 417-419.
12. Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58, 1347-1363.
13. McKeigue, P.M., Carpenter, J.R., Parra, E.J. & Shriver, M.D. (2000) Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African-American populations. Ann Hum Genet 64, 171-186.
14. Mirnics, K., Middleton, F.A., Stanwood, G.D., Lewis, D.A. & Levitt, P. (2001) Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 6, 293-301.
15. Morris, D.W., Rodgers, A., McGhee, K.A., Schwaiger, S., Scully, P., Quinn, J., Meagher, D., Waddington, J.L., Gill, M. & Corvin, A.P. (2004) Confirming RGS4 as a susceptibility gene for schizophrenia. Am J Med Genet 15, 50-53.
16. O'Connell, J.R. & Weeks, P.Y. (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63, 259-266.
17. Seltman, H., Roeder, K. & Devlin, B. (2003) Evolutionary-based association analysis using haplotype data. Genet Epidemiol 25, 48-58.
18. Spielman, R.S. & Ewens, W.J. (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59, 983-989.
19. Williams, N.M., Preece, A., Spurlock, G., Norton, N., Williams, H.J., McCreadie, R.G., Buckland, P., Sharkey, V., Chowdari, K.V., Zammit, S., Nimgaonkar, V., Kirov, G., Owen, M.J. & O'Donovan, M.C. (2004) Support RGS4 as a susceptibility gene for schizophrenia. Biol Psychiatry 15, 192-195.
20. Zhao, J.H., Curtis, D. & Sham, P.C. (2000) Model-free analysis and permutation tests for allelic associations. Hum Hered 50, 133-139.
21. Zheng, C. & Elston, B.C. (1999) Multipoint linkage disequilibrium mapping with particular reference to the African-American population. Genet Epidemiol 17, 79-101.
22. Zhong, H. & Neubig, R. (2001) Regulator of G protein signalling proteins: novel multifunctional drug targets. J Pharmacol Exp Ther 291, 837-845.