Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase

Cell and Tissue Research

Volumn 319, Issue 2, 2005, Pages 267-278

  Sabbieti, Maria Giovanna ^a   Marchetti, Luigi ^a   Gabrielli, Maria Gabriella ^a   Menghi, Maura ^a   Materazzi, Stefano ^b   Menghi, Giovanna ^a   Raisz, Lawrence G ^c   Hurley, Maria M ^c  

^a Dept Compar Morphology Biochem ^*  (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

Confocal laser scanning microscopy; Fibroblast growth factor 2 FGF receptor 2; Mitogen activated protein kinases ERK2; Prostaglandin F2 ; Rat osteoblasts; Transmission electron microscopy

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CYCLOHEXIMIDE; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FLUPROSTENOL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN F2 ALPHA; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL LINE; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TRANSFORMED; CELL NUCLEUS; DINOPROST; FIBROBLAST GROWTH FACTOR 2; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; MICROSCOPY, IMMUNOELECTRON; MITOGEN-ACTIVATED PROTEIN KINASE 3; NUCLEAR ENVELOPE; OSTEOBLASTS; PROSTAGLANDINS; PROSTAGLANDINS F, SYNTHETIC; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; RNA, MESSENGER;

EID: 12944298276     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-004-0981-8     Document Type: Article

References (44)

1. Aspenberg P, Thorngren K, Lohmander LS (1991) Dose dependent Stimulation of bone by induction by basic fibroblast growth factor in rats. Acta Orthop Scand 62:481-484
2. 1 phase cell cycle specific in bovine aortic endothelial cells. Embo J 9:1511-1517
3. 1 transition. Proc Natl Acad Sci USA 84:6770-6774
4. Canalis E, Centrella M, McCarthy T (1988) Effects of basic fibroblast growth factor on bone formation in vitro. J Clin Invest 81:1572-1577
5. Chaudhary LR, Avioli LV (1997) Activation of extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) by FGF-2 and PDGF-BB in normal human osteoblastic and bone marrow stromal cells: differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblastic cells. Biochem Biophys Res Commun 238:134-139
6. Chaudhary LR, Avioli LV (1998)Identification and activation of mitogen-activated protein (MAP) kinase in normal human osteoblastic and bone marrow stromal cells: attenuation of MAP kinase activation by cAMP, parathyroid hormone and forskolin.Mol Cell Biochem 178:59-68
7. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
8. Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556
9. Fall PM, Breault DT, Raisz LG (1994) Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic clonal cell line Py1a: structure activity relations and signal transduction mechanism. J Bone Miner Res 9:1935-1943
10. Globus RK, Patterson-Buckendahl P, Gospodarowicz D (1988) Regulation of bovine bone cell proliferation by fibroblast growth factor and transforming growth factor β. Endocrinology 123:98-105
11. Globus RK, Plouet J, Gospodarowicz D (1989) Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology 124:1539-1547
12. Hurley MM, Abreu C, Harrison JR, Lichtler A, Raisz LG, Kream BE (1993) Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells. J Biol Chem 268:5588-5593
13. Hurley MM, Abreu C, Tetradis S, Kream BE, Raisz LG (1996a) Parathyroid hormone and cAMP increase the expression of fibroblast growth factor-2 and the fibroblast growth factor receptors in osteoblastic cells. J Bone Miner Res 14:776-783
14. Hurley MM, Marcello K, Abreu C, Kessler M (1996b) Signal transduction by basic fibroblast growth factor in rat osteoblastic Py1a cells. J Bone Miner Res 11:1256-1263
15. Hurley MM, Marie P, Florkiewicz RZ (2002) Fibroblast growth factor (FGF) and FGF receptor families in bone. In: Belizikian J, Raisz LG, Rodan G (eds) Principles of bone biology, 2nd edn. Academic Press, New York, pp 825-851
16. Klingenberg O, Wiedlocha A, Rapak A, Khnykin D, Citores L, Olnes S (2000) Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus. J Cell Sci 113:1827-1838
17. Marchese C, Mancini P, Belleudi F, Felici A, Gradini R, Sansolini T, Frati L, Torrisi MR (1998) Receptor-mediated endocytosis of keratinocyte growth factor. J Cell Sci 111:3517-3527
18. Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.Cell 80:179-185
19. Mansukani A, Moscatelli D, Talarico D, Levystka V, Basilico CA (1990) Murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF. Proc Natl Acad Sci USA 87:4378-4382
20. Matsuda N, Morita N, Matsuda K, Watanabe M (1998) Proliferation and differential activation of MAP kinases in response to epidermal growth factor, hypoxia, and mechanical stress in vitro. Biochem Biophys Res Commun 49:350-354
21. McCarthy TL, Centrella M, Canalis E (1989) Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells. Endocrinology 125:2118-2126
22. Mehta VB, Connors L, Wang HC, Chiu IMM (1998) Fibroblast variants nonresponsive to fibroblast growth factor 1 are defective in its nuclear translocation. Biol Chem 273:4197-4205
23. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR, Schlessinger J (1997) Structures of the tyrosine kinase domain of fibroblasts growth factor receptor in complex with inhibitors. Science 276:955-966
24. Molteni A, Modrowski D, Hott M, Marie PJ (1999) Differential expression of fibroblast growth factor receptor-1, -2, and -3 and β-syndecan-1, -2, and -4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro. Bone 24:337-347
25. 2 on mineralization of bone nodules formed by fetal rat calvarial cells. Calcif Tissue Int 55:451-457
26. Nishida E, Gotoh Y (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18:128-131
27. Norrdin RW, Jee WSS, High WB (1990) The role of prostaglandins in bone in vivo. Prostaglandins Leukot Fatty Acids 41:139-150
28. mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA 90:8319-8323
29. 2α induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation. Endocrinology 132:1505-1513
30. 2 on bone formation in cultured fetal rat calvariae: interaction with cortisol. Endocrinology 126:1654-1659
31. 2 in organ culture. Prostaglandins 8:377-385
32. 1 (I) procollagen gene transcription and promoter activity in the immortalized rat osteoblastic clonal cell line Py1a. Mol Endocrinol 7:17-22
33. Rodan SB, Wesolowski G, Yoon K, Rodan GA (1989) Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin and type I collagen mRNA levels in ROS 17/2.8 cells. J Biol Chem 264:19934-19941
34. Sabbieti MG, Marchetti L, Abreu C, Montero A, Hand AR, Raisz LG, Hurley MM (1999) Prostaglandins regulate the expression of fibroblast growth factor-2 in bone. Endocrinology 140:434-444
35. Sabbieti MG, Marchetti L, Hurley MM, Menghi G (2000) Nuclear and cytoplasmic lectin receptor sites in rat Py1a osteoblasts. Histol Histopathol 15:1107-1117
36. Sambrook J, Fritsch EF, Maniatis T (eds) (1989) Molecular cloning, a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
37. 2 induces the transition from nonadherent to adherent bone marrow mesenchymal precursor cells via a cAMP/EP2-mediated mechanism. Prostaglandins 49:383-395
38. Shen V, Kohler G, Huang J, Huang SS, Peck WA (1989) An acidic fibroblast growth factor stimulates DNA synthesis, inhibits collagen and alkaline phosphatase synthesis and induces resorption in bone. Bone Miner 7:205-219
39. Stachowiak M, Moffett J, Joy A, Puchacz E, Florkiewicz R, Stachowiak E (1994) Regulation of bFGF gene expression and subcellular distribution of bFGF protein in adrenal medullary cells. J Cell Biol 127:203-223
40. Stachowiak MK, Maher PA, Joy A, Mordechai E, Stachowiak EK (1996) Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells. Mol Biol Cell 7:1299-1317
41. Suzuki A, Palmer G, Bonjour JP, Caverzasio J (2000) Stimulation of sodium-dependent phosphate transport and signaling mechanism induced by basic fibroblast growth factor in MC3T3-E1 osteoblast-like cells. J Bone Miner Res 15:95-102
42. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354
43. Wadhwa S, Godwin SL, Peterson DR, Epstein MA, Raisz LG, Pilbeam CC (2002) Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway. J Bone Miner Res 17:266-274
44. Woodiel FN, Fall PM, Raisz LG (1996) Anabolic effects of prostaglandins in cultured fetal rat calvariae: structure-activity relations and signal transduction pathway. J Bone Miner Res 11:1249-1255