The generalizability of observational data to elderly patients was dependent on the research question in a systematic review

Journal of Clinical Epidemiology

Volumn 58, Issue 2, 2005, Pages 130-137

  Gross, Cary P ^a,e   Garg, Pushkal P ^b,c,d   Krumholz, Harlan M ^a,e  

^a YALE NEW HAVEN HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cooperative Cardiovascular Project; Generalizability; Global utilization of streptokinase and t pa for occluded coronary arteries; Myocardial infarction; Randomized controlled trials; Validity

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FIBRINOLYTIC AGENT; STREPTOKINASE; TISSUE PLASMINOGEN ACTIVATOR;

ACUTE HEART INFARCTION; ANGIOGRAPHY; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CLINICAL TRIAL; DRUG EFFICACY; GEOGRAPHY; HEART ATRIUM FIBRILLATION; HUMAN; MEDICAL RESEARCH; OBSERVATION; OUTCOMES RESEARCH; PATIENT CARE; PREDICTION; PRIORITY JOURNAL; QUESTIONNAIRE; REVIEW; SYSTEMATIC REVIEW;

EID: 12944296619     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2004.10.001     Document Type: Article

References (29)

1. C. Gross, R. Mallory, A. Heiat, and H. Krumholz Reporting the recruitment process in clinical trials: who are these patients and how did they get there? Ann Intern Med 137 2002 10 16
2. A. Britton, M. McKee, N. Black, K. McPherson, C. Sanderson, and C. Bain Threats to applicability of randomised trials: exclusions and selective participation J Health Serv Res Policy 4 1999 112 121
3. S.S. Rathore, K.P. Weinfurt, C.P. Gross, and H.M. Krumholz Validity of a simple ST-elevation acute myocardial infarction risk index: are randomized trial prognostic estimates generalizable to elderly patients? Circulation 107 2003 811 816
4. S. Ellenberg, and M. Foulkes The utility of large simple trials in the evaluation of AIDS treatment strategies Stat Med 13 1994 405 415
5. J. Gore, C. Granger, M. Simoons, M. Sloan, W. Weaver, and H. White Stroke after thrombolysis: mortality and functional outcomes in the GUSTO-1 trial Circulation 92 1995 2811 2818
6. L. Brass, J. Lichtman, Y. Wang, J. Gurwitz, M. Radford, and H. Krumholz Intracranial hemorrhage associated with thrombolytic therapy for elderly patients with acute myocardial infarction Stroke 31 2000 1802 1811
7. M. Pfisterer, J. Cox, C. Granger, S. Brener, C. Naylor, and R. Califf Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-1 experience J Am Coll Cardiol 32 1998 634 640
8. H. Krumholz, M. Radford, Y. Wang, J. Chen, A. Heiat, and T. Marciniak National Use and Effectiveness of beta-blockers for the treatment of elderly patients after acute myocardial infarction JAMA 280 1998 623 629
9. L. Pilote, R. Califf, S. Sapp, D. Miller, D. Mark, and W. Weaver Regional variation across the United States in the management of acute myocardial infarction N Engl J Med 333 1995 565 572
10. K. Lee, L. Woodlief, E. Topol, W.D. Weaver, A. Betriu, J. Col, M. Simoons, P. Aylward, F. Van de Werf, and R.M. Califf Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction Circulation 91 1995 1659 1668
11. H. Krumholz, J. Chen, Y. Wang, M. Radford, Y. Chen, and T. Mariniak Comparing AMI mortality among hospitals in patients 65 years of age and older Circulation 99 1999 2986 2992
12. S.S. Rathore, A.K. Berger, and K.P. Weinfurt Acute myocardial infarction complicated by atrial fibrillation in the elderly: prevalence and outcomes Circulation 101 2000 969 974
13. B.S. Crenshaw, S.R. Ward, C.B. Granger, A.L. Stebbins, E.J. Topol, and R.M. Califf Atrial fibrillation in the setting of acute myocardial infarction: the GUSTO-I experience. Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries J Am Coll Cardiol 30 1997 406 413
14. W. Weaver, H. White, R. Wilcox, P. Aylward, D. Morris, and A. Guerci Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy JAMA 275 1996 777 782
15. S. Gan, S. Beaver, P. Houck, M. MacLehose, H. Lawson, and L. Chan Treatment of acute myocardial infarction and 30-day mortality among women and men N Engl J Med 343 2000 8 15
16. S. Rathore, Y. Wang, M. Radford, D. Ordin, and H. Krumholz Sex differences in cardiac catheterization after acute myocardial infarction: the role of procedure appropriateness Ann Intern Med 137 2002 487 493
17. S. Sheifer, S. Rathore, and B. Bersh Time to presentation with acute myocardial infarction in the elderly Circulation 102 2000 1651 1656
18. W. Gibler, P. Armstron, E. Ohman, W. Weaver, A. Stebbins, and J. Gore Persistence of delays in presentation and treatment for patients with acute myocardial infarction Ann Emerg Med 39 2002 123 130
19. A. Berger, M. Radfort, and H. Krumholz Factors associated with delay in reperfusion therapy in elderly patients with acute myocardial infarction: analysis of the cooperative cardiovascular project Am Heart J 139 2000 985 992
20. H. Krumholz, M. Radford, Y. Wang, J. Chen, and T. Marciniak Early beta-blockers for acute myocardial infarction in elderly patients Ann Intern Med 131 1999 648 654
21. K. Teo, S. Yusuf, and C. Furberg Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction: an overview of results from randomized controlled trials JAMA 270 1993 1589 1595
22. The GUSTO Investigators An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction N Engl J Med 329 1993 673 682
23. E. Guadagnoli, M.B. Landrum, E.A. Peterson, M.T. Gahart, T.J. Ryan, and B.J. McNeil Appropriateness of coronary angiography after myocardial infarction among Medicare beneficiaries: managed care versus fee for service N Engl J Med 343 2000 1460 1466
24. P.C. Lambert, A.J. Sutton, K.R. Abrams, and D.R. Jones A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis J Clin Epidemiol 55 2002 86 94
25. J.A. Berlin, J. Santanna, C.H. Schmid, L.A. Szczech, and H.I. Feldman Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head Stat Med 21 2002 371 387
26. S.S. Rathore, Y. Wang, and H.M. Krumholz Sex-based differences in the effect of digoxin for the treatment of heart failure N Engl J Med 347 2002 1403 1411
27. S.S. Rathore, J.P. Curtis, Y. Wang, M.R. Bristow, and H.M. Krumholz Association of serum digoxin concentration and outcomes in patients with heart failure JAMA 289 2003 871 878
28. www.grants2.nih.gov/grants/guide/notice-files/NOT-OD-03-032.html. Accessed May 14, 2003.
29. www.nhlbi.nih.gov/resources/deca/directry.htm. Accessed May 15, 2003.