Rapid screening of Aspergillus terreus mutants for overproduction of lovastatin

World Journal of Microbiology and Biotechnology

Volumn 21, Issue 2, 2005, Pages 123-125

  Vilches Ferron M A ^a   Casas Lopez J L ^a   Sanchez Perez J A ^a   Fernandez Sevilla J M ^a   Chisti, Y ^b  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b MASSEY UNIVERSITY   (New Zealand)

Author keywords

Aspergillus terreus; Candida albicans; Lovastatin; Mutation; Screening

Indexed keywords

ASSAYS; BIOTECHNOLOGY; MUTAGENESIS; SCREENING; YEAST;

CANDIDA ALBICANS; INHIBITION ZONES; LOVASTATIN; MUTANTS;

MICROBIOLOGY;

ASPERGILLUS; ASPERGILLUS TERREUS; CANDIDA; CANDIDA ALBICANS;

EID: 12944260469     PISSN: 09593993     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11274-004-3045-z     Document Type: Article

References (11)

1. Alberts, A.W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., Patchett, A., Monaghan, R., Currie, S., Stapley, E., Albers-Schonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J. & Springer, J. 1980 Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proceedings of the National Academy of Sciences of the USA 77, 3957-3961.
2. Endo, A., Kuroda, M. & Tsujita, Y. 1976a ML-236 A, ML236 B and ML-236 C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. Journal of Antibiotics 29, 1346-1348.
3. Endo, A., Kuroda, M. & Tanazawa, K. 1976b Competitive inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase by ML-236 A and ML236 B fungal metabolites having hypocholesterolemic activity. FEBS Letters 72, 323-326.
4. Juzlova, P., Martinkova, L. & Kren, V. 1996 Secondary metabolites of the fungus Monascus: a review. Journal of Industrial Microbiology 16, 163-170.
5. Kumar, M.S., Jana, S.K., Senthil, V., Shashanka, V., Kumar, S.V. & Sadhukhan, A.K. 2000a Repeated fed-batch process for improving lovastatin production. Process Biochemistry 36, 363-368.
6. Kumar, M.S., Kumar, P.M., Sarnaik, H.M. & Sadhukhan, A.K. 2000b A rapid technique for screening of lovastatin-producing strains of Aspergillus terreus by agar plug and Neurospora crassa bioassay. Journal of Microbiological Methods 40: 99-104.
7. Manzoni, M., Rollini, M., Bergomi, S. & Cavazzoni, V. 1998 Production and purification of statins from Aspergillus terreus strains. Biotechnology Techniques 12, 529-532.
8. Manzoni, M., Bergomi, S., Rollini, M. & Cavazzoni, V. 1999 Production of statins by filamentous fungi. Biotechnology Letters 21, 253-257.
9. Novak, N., Gerdin, S. & Berovic, M. 1997 Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process. Biotechnology Letters 19, 947-948.
10. Szakács, G., Morovján, G. & Tengerdy, R.P. 1998 Production of lovastatin by a wild strain of Aspergillus terreus. Biotechnology Letters 20, 411-415.
11. Vinci, V.A., Hoerner, T.D., Coffmann, A.D., Schimmel, T.G., Dabora, R.L., Kirpeker, A.C., Ruby, C.L. & Stieber, R.W. 1991 Mutants of a lovastatin hyperproducing Aspergillus terreus deficient in the production of sulochrin. Journal of Industrial Microbiology 8, 113-120.