Mutagenesis of a novel gene in the prcA-prtP protease locus affects expression of Treponema denticola membrane complexes

Infection and Immunity

Volumn 73, Issue 2, 2005, Pages 1252-1255

  Bian, Xue Lin ^a,c   Wang, Hong Tao ^a   Ning, Yu ^a   Lee, Si Young ^a,b   Fenno, J Christopher ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Gangneung Wonju National University   (South Korea)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; HOST CELL; MEMBRANE; MUTAGENESIS; NONHUMAN; OPERON; PRCA GENE; PRIORITY JOURNAL; PRTP GENE; TREPONEMA DENTICOLA;

BACTERIAL PROTEINS; CHYMOTRYPSIN; MEMBRANE PROTEINS; MUTATION; PORINS; SUBTILISINS; TREPONEMA DENTICOLA;

EID: 12844278881     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.2.1252-1255.2005     Document Type: Article

References (21)

1. Amin, M., A. C. S. Ho, J. Y. Lin, A. P. Batista da Silva, M. Glogauer, and R. P. Ellen. 2004. Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein. Infect. Immun. 72:3650-3654.
2. Asai, Y., T. Jinno, and T. Ogawa. 2003. Oral treponemes and their outer membrane extracts activate human gingival epithelial cells through Toll-like receptor 2. Infect. Immun. 71:717-725.
3. Batista da Silva, A. P., W. Lee, E. Bajenova, C. A. McCulloch, and R. P. Ellen. 2004. The major outer sheath protein of Treponema denticola inhibits the binding step of collagen phagocytosis in fibroblasts. Cell. Microbiol. 6:485-498.
4. Chi, B., M. Qi, and H. K. Kuramitsu. 2003. Role of dentilisin in Treponema denticola epithelial cell layer penetration. Res. Microbiol. 154:637-643.
5. Deng, Q. D., Y. Han, X. Xia, and H. K. Kuramitsu. 2001. Effects of the oral spirochete Treponema denticola on interleukin-8 expression from epithelial cells. Oral Microbiol. Immunol. 16:185-187.
6. Egli, C., W. K. Leung, K. H. Müller, R. E. Hancock, and B. C. McBride. 1993. Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola. Infect. Immun. 61:1694-1699.
7. Fenno, J. C., P. M. Hannam, W. K. Leung, M. Tamura, B. C. McBride, and V.-J. Ditto. 1998. Cytopathic effects of the major surface protein and the chymotrypsinlike protease of Treponema denticola. Infect. Immun. 66:1869-1877.
8. Fenno, J. C., S. Y. Lee, C. H. Bayer, and Y. Ning. 2001. The opdB locus encodes the trypsin-like peptidase activity of Treponema denticola. Infect. Immun. 69:6193-6200.
9. Fenno, J. C., K.-H. Müller, and B. C. McBride. 1996. Sequence analysis, expression and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola. J. Bacteriol. 178:2489-2497.
10. Fenno, J. C., G. W. K. Wong, P. M. Hannam, and B. C. McBride. 1998. Mutagenesis of outer membrane virulence determinants of the oral spirochete Treponema denticola. FEMS Microbiol. Lett. 163:209-215.
11. Fletcher, H. M., H. A. Schenkein, R. M. Morgan, K. A. Bailey, C. R. Berry, and F. L. Macrina. 1995. Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene. Infect. Immun. 63:1521-1528.
12. Grenier, D., V.-J. Uitto, and B. C. McBride. 1990. Cellular location of a Treponema denticola chymotrypsinlike protease and importance of the protease in migration through the basement membrane. Infect. Immun. 58:347-351.
13. Haapasalo, M., K.-H. Müller, V.-J. Uitto, W. K. Leung, and B. C. McBride. 1992. Characterization, cloning, and binding properties of the major 53-kilodalton Treponema denticola surface antigen. Infect. Immun. 60:2058-2065.
14. Haapasalo, M., U. Singh, B. C. McBride, and V.-J. Uitto. 1991. Sulfhydryl-dependent attachment of Treponema denticola to laminin and other proteins. Infect. Immun. 59:4230-4237.
15. Hashimoto, M., S. Ogawa, Y. Asai, Y. Takai, and T. Ogawa. 2003. Binding of Porphyromonas gingivalis fimbriae to Treponema denticola dentilisin. FEMS Microbiol. Lett. 226:267-271.
16. Ishihara, K., H. K. Kuramitsu, and K. Okuda. 2004. A 43-kDa protein of Treponema denticola is essential for dentilisin activity. FEMS Microbiol. Lett. 232:181-188.
17. Ishihara, K., T. Miura, H. K. Kuramitsu, and K. Okuda. 1996. Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin). Infect. Immun. 64:5178-5186.
18. Lee, S. Y., X.-L. Bian, G. W. K. Wong, P. M. Hannam, B. C. McBride, and J. C. Fenno. 2002. Cleavage of Treponema denticola PrcA polypeptide to yield protease complex-associated proteins PrcA1 and PrcA2 is dependent on PrtP. J. Bacteriol. 184:3864-3870.
19. Li, H., J. Ruby, N. Charon, and H. Kuramitsu. 1996. Gene inactivation in the oral spirochete Treponema denticola: construction of an flgE mutant. J. Bacteriol. 178:3664-3667.
20. Uitto, V.-J., D. Grenier, E. C. S. Chan, and B. C. McBride. 1988. Isolation of a chymotrypsinlike enzyme from Treponema denticola. Infect. Immun. 56:2717-2722.
21. Vesey, P. M., and H. K. Kuramitsu. 2004. Genetic analysis of Treponema denticola ATCC 35405 biofilm formation. Microbiology 150:2401-2407.