Monoclonal antibody-polyethyleneimine conjugates targeting Her-2/neu or CD90 allow cell type-specific nonviral gene delivery

Journal of Controlled Release

Volumn 102, Issue 3, 2005, Pages 737-747

  Strehblow, Claudia ^a   Schuster, Maj ^b   Moritz, Thomas ^a   Kirch, Hans Christoph ^a   Opalka, Bertram ^a   Petri, Jean Bernhard ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b IBFB Pharma GmbH   (Germany)

Author keywords

Gene transfer; Her 2 neu (Trastuzumab); Positional targeting; Thy 1

Indexed keywords

ANTIGENS; CHARACTERIZATION; COUPLINGS; DNA; GENE TRANSFER; PROTEINS;

ANTOIBODY-POLYETHYLENEIMINE CONJUGATES; FIBROBLASTS; GENE DELIVERY; POLYETHYLENEIMINE (PEI);

ANTIBODIES;

3 (2 PYRIDYLDITHIO)PROPIONIC ACID N HYDROXYSUCCINIMIDE ESTER; 3 [2 [2 (VINYLSULFONYL)ETHYLTHIO]ETHYL]QUINAZOLINE 2,4(1H,3H) DIONE; CARBOXYLIC ACID DERIVATIVE; ENHANCED GREEN FLUORESCENT PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; N SUCCINIMIDYL 4 (MALEIMIDOMETHYL)CYCLOHEXANE CARBOXYLATE; POLYETHYLENEIMINE; PROPIONIC ACID DERIVATIVE; QUINAZOLINE DERIVATIVE; THY 1 ANTIGEN; TRASTUZUMAB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BREAST CANCER; CELL LINE; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG EFFICACY; DRUG SCREENING; DRUG SELECTIVITY; DRUG TARGETING; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MODEL; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, THY-1; CELLS, CULTURED; GENE TARGETING; GENES, ERBB-2; HUMANS; MICE; POLYETHYLENEIMINE; PROTEIN BINDING; TRANSFECTION;

EID: 12844273733     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.10.033     Document Type: Article

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