Effects of oral fat load on insulin output and glucose tolerance in healthy control subjects and obese patients without diabetes

Diabetes Care

Volumn 28, Issue 2, 2005, Pages 360-365

  Wuesten, Oliver ^a   Balz, Cristoph H ^a,b   Bretzel, Reinhard G ^a   Kloer, Hans Ulrich ^a   Hardt, Philip D ^a,c  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c Third Medical Department   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LIPID EMULSION;

ARTICLE; BODY FAT; CONTROLLED STUDY; FAT INTAKE; FATTY ACID BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; HYPERINSULINEMIA; INSULIN RELEASE; INTRAVENOUS GLUCOSE TOLERANCE TEST; NORMAL HUMAN; OBESITY; PANCREAS ISLET BETA CELL;

ADULT; BLOOD GLUCOSE; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; OBESITY;

EID: 12844273383     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.28.2.360     Document Type: Article

References (27)

1. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C: Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88:960-966, 1991
2. Boden G, Chen X: Effects of fat on glucose uptake and utilization in patients with non-insulin-dependant diabetes. J Clin invest 96:1261-1268, 1995
3. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI: Mechanisms of free fatty acid induced insulin resistance in humans. J Clin Invest 97:2859-2865, 1996
4. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103:253-259, 1999
5. Boden G, Chen X, Ruiz J, White JV, Rossetti L: Mechanisms of fatty acid induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
6. Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J: Uptake and release of glucose by the human kidney: postabsorptive rates and responses to epinephrine. J Clin Invest 96:2528-2533, 1995
7. Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA: Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72:1737-1747, 1983
8. Bevilacqua S, Buzzigoli G, Bonadonna R, Brandi LS, Oleggini M, Boni C, Geloni M, Ferrannini E: Operations of Randle's cycle in patients with NIDDM. Diabetes 39: 383-389, 1990
9. Fanelli C, Calderone S, Epifano L, De Vincenzo A, Modarelli F, Pampanelli S, Perriello G, De Feo P, Brunetti P, Gerich JE: Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest 92:1617-1622, 1993
10. Felber JP, Vannotti A: Effects of fat infusion on glucose tolerance and plasma insulin levels. Med Exp Int J Exp Med 10: 153-156, 1964
11. Pelkonen R, Miettinen TA, Taskinen MR, Nikkilä EA: Effect of acute elevation of plasma glycerol, triglyceride and NEFA levels on glucose utilization and plasma insulin. Diabetes 17:76-82, 1968
12. Crespin SR, Grennough WB, Steinberg D: Stimulation of insulin secretion by long-chain free fatty acids: a direct pancreatic effect. J Clin invest 52:1979-1984, 1973
13. Boden G, Chen X, Rosner J, Barton M: Effects of 48-hour fat infusion on insulin secretion and glucose utilization. Diabetes 44:1239-1242, 1995
14. Boden G: Obesity, free fatty acids, and insulin resistance. Curr Opin Endocrinol Diabetes 8:235-239, 2001
15. Boden G, Chen X: Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. Diabetes 48:577-583, 1999
16. Bergman RN, Beard JC, Chen M: The minimal modeling method. Assessment of insulin sensitivity and beta-cell function in vivo. In Methods in Diabetes Research. Clarke WL, Larner J, Pohl SL, Eds. New York, John Wiley & Sons, 1986, p. 15-34
17. Lukaski HC: Body composition assessment using impedance methods. In Obesity. 1st ed. Björntorp P, Brodoff BN, Eds. Philadelphia, Lippincott, 1982, p. 67-79 1992
18. Paolisso G, Gambardella A, Amato L, Tortoriello R, D'Amore A, Varricchio M, D'Onofrio F: Opposite effects of shortand long-term fatty acid infusion on insulin secretion in healthy subjects. Diabetologia 38:1295-1299, 1995
19. Bonadonna RC, Zych K, Boni C, Ferrannini E, DeFronzo RA: Time dependence of the interaction between lipid and glucose in humans. Am J Physiol 257:E49-E56, 1989
20. Reaven GM: Banting Lecture 1988: Role of insulin resistance in human disease. Diabetes 37:1595-607, 1988
21. Carroll KF, Nestel PJ: Effect of long-chain triglyceride on human insulin secretion. Diabetes 21:923-929, 1972
22. Kraegen EW, Chisholm DJ, Young JD, Lazarus L: The gastrointestinal stimulus to insulin release. J Clin invest 49:524-529, 1970
23. Thorell J, Persson B, Sterkey G: Effect of fat infusion on plasma glucose, NEFA, glycerol and insulin levels during i.v. and oral glucose tolerance tests. Diabetologia 2: 232, 1966
24. Gibson T, Fuller JH, Grainger SL, Jarrett RJ, Keen H: Intralipid triglyceride and oral glucose. Diabetologia 10:97-100, 1974
25. Zhou M-Y, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
26. Hardt PD, Hauenschild A, Nalop J, Marzeion AM, Jaeger C, Teichmann J, Bretzel RG, Hollenhorst M, Kloer HU: High prevalence of exocrine pancreatic insufficiency in diabetes mellitus: a multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients. Pancreatology 3:395-402, 2003
27. Hardt PD, Hauenschild A, Jaeger C, Teichmann J, Bretzel RG, Kloer HU: High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. Dig Dis Sci 48: 1688-92, 2003