The immunomodulating properties of human respiratory syncytial virus and immunostimulating complexes containing Quillaja saponin components QH-A, QH-C and ISCOPREP™703

FEMS Immunology and Medical Microbiology

Volumn 43, Issue 2, 2005, Pages 269-276

  Hu, Ke Fei ^a,c   Regner, Matthias ^d   Siegrist, Claire Anne ^d   Lambert, Paul ^d   Chen, Margaret ^b   Bengtsson, Karin Lövgren ^c   Morein, Bror ^a,c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b Center for Vaccinology and Neonatal Immunology   (Switzerland)

^c SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^d ISCONOVA AB   (Sweden)

Author keywords

Cytokine; ISCOMs; Th1; Th2; Vaccine

Indexed keywords

GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 4; INTERLEUKIN 5; ISCOM; SAPONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; IMMUNIZATION; IMMUNOMODULATION; IMMUNOSTIMULATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUILLAJA; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; TH1 CELL; VIRUS INFECTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, VIRAL; FEMALE; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-5; ISCOMS; MICE; QUILLAJA; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS VACCINES; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; VACCINATION; VIRAL PROTEINS;

EID: 12844268178     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.femsim.2004.08.010     Document Type: Article

References (26)

1. K. McIntosh, and R.M. Chanock Respiratory Syncytial Virus B.M. Fields Virology 1990 Raven Press New York 1045 1072
2. E.J. Stott, and G. Taylor Respiratory Syncytial Virus. Brief Review Arch. Virol. 84 1985 1 52
3. M. Trudel, F. Nadon, C. Simard, F. Belanger, R. Alain, C. Seguin, and G. Lussier Comparison of caprine, human and bovine strains of respiratory syncytial virus Arch. Virol. 107 1989 141 149
4. B.R. Murphy, G.A. Prince, P.L. Collins, K. Van Wyke Coelingh, R.A. Olmsted, M.K. Spriggs, R.H. Parrott, H.W. Kim, C.D. Brandt, and R.M. Chanock Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses Virus Res. 11 1988 1 15
5. K. West, L. Petrie, C. Konoby, D.M. Haines, V. Cortese, and J.A. Ellis The efficacy of modified-live bovine respiratory syncytial virus vaccines in experimentally infected calves Vaccine 18 1999 907 919
6. P. Schreiber, J.P. Matheise, F. Dessy, M. Heimann, J.J. Letesson, P. Coppe, and A. Collard High mortality rate associated with bovine respiratory syncytial virus (BRSV) infection in Belgian white blue calves previously vaccinated with an inactivated BRSV vaccine J. Vet. Med. B Infect. Dis. Vet. Public Health 47 2000 535 550
7. S.M. van Schaik, N. Obot, G. Enhorning, K. Hintz, K. Gross, G.E. Hancock, A.M. Stack, and R.C. Welliver Role of interferon gamma in the pathogenesis of primary respiratory syncytial virus infection in BALB/c mice J. Med. Virol. 62 2000 257 266
8. S.M. van Schaik, R.C. Welliver, and J.L. Kimpen Novel pathways in the pathogenesis of respiratory syncytial virus disease Pediatr. Pulmonol. 30 2000 131 138
9. B. Morein, and K.L. Bengtsson Immunomodulation by iscoms, immune stimulating complexes Methods 19 1999 94 102
10. S.M. Varga, E.L. Wissinger, and T.J. Braciale The attachment (G) glycoprotein of respiratory syncytial virus contains a single immunodominant epitope that elicits both Th1 and Th2 CD4+ T cell responses J. Immunol. 165 2000 6487 6495
11. B. Morein, B. Sundquist, S. Höglund, K. Dalsgaard, and A. Osterhaus Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses Nature 308 1984 457 460
12. K. Lövgren-Bengtsson, and B. Morein The ISCOM Technology D.T. O'Hagan Methods in Molecular Medicine, Vaccine Adjuvants: Preparation Methods and Research Protocols vol. 42 2000 Humana Press Totowa, NJ 239 258
13. C.R. Kensil, U. Patel, M. Lennick, and D. Marciani Separation and characterization of saponins with adjuvant activity from Quillaja saponaria molina cortex J. Immunol. 146 1991 431 437
14. B. Ronnberg, M. Fekadu, and B. Morein Adjuvant activity of non-toxic Quillaja saponaria molina components for use in ISCOM matrix Vaccine 13 1995 1375 1382
15. S. Behboudi, B. Morein, and M. Villacres-Eriksson In vitro activation of antigen-presenting cells (APC) by defined composition of Quillaja saponaria molina triterpenoids Clin. Exp. Immunol. 105 1996 26 30
16. S. Behboudi, B. Morein, and M. Villacres-Eriksson In vivo and in vitro induction of IL-6 by Quillaja saponaria molina triterpenoid formulations Cytokine 9 1997 682 687
17. F. Houssiau, and J. Van Snick IL6 and the T-cell response Res. Immunol. 143 1992 740 743
18. M. Johansson, and K. Lovgren-Bengtsson Iscoms with different quillaja saponin components differ in their immunomodulating activities Vaccine 17 1999 2894 2900
19. A. Sjolander, B. van't Land, and K. Lovgren Bengtsson Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-like immune responses Cell. Immunol. 177 1997 69 76
20. K.F. Hu, M. Elvander, M. Merza, L. Åkerblom, A. Brandenburg, and B. Morein The immunostimulating complex (ISCOM) is an efficient mucosal delivery system for respiratory syncytial virus (RSV) envelope antigens inducing high local and systemic antibody responses Clin. Exp. Immunol. 113 1998 235 243
21. K.F. Hu, J. Ekstrom, M. Merza, K. Lovgren-Bengtsson, and B. Morein Induction of antibody responses in the common mucosal immune system by respiratory syncytical virus immunostimulating complexes Med. Microbiol. Immunol. (Berl.) 187 1999 191 198
22. B. Morein, and K.F. Hu Biological Aspects and Prospects for Adjuvants and Delivery Systems R.W. Ellis New Vaccine Technology 1999 Landes Bioscience Georgetown, TX 274 291 (Chapter 16)
23. K. Hu, M. Chen, I. Abusugra, F. Monaco, and B. Morein Different respiratory syncytial virus and Quillaja saponin formulations induce murine peritoneal cells to express different proinflammatory cytokine profiles FEMS Immunol. Med. Microbiol. 31 2001 105 112
24. M. Villacres-Eriksson, S. Behboudi, A.J. Morgan, G. Trinchieri, and B. Morein Immunomodulation by Quillaja saponaria adjuvant formulations: in vivo stimulation of interleukin 12 and its effects on the antibody response Cytokine 9 1997 73 82
25. R.E. Smith, A.M. Donachie, F.H. McLaren, and A.M. Mowat Preservation of mucosal and systemic adjuvant properties of ISCOMS in the absence of functional interleukin-4 or interferon-gamma Immunology 93 1998 556 562
26. M. Chen, K.F. Hu, B. Rozell, C. Orvell, B. Morein, and P. Liljestrom Vaccination with recombinant alphavirus or immune-stimulating complex antigen against respiratory syncytial virus J. Immunol. 169 2002 3208 3216