Increased expression of polypyrimidine tract binding protein results in higher insulin mRNA levels

Biochemical and Biophysical Research Communications

Volumn 328, Issue 1, 2005, Pages 38-42

  Fred, Rikard G ^a   Welsh, Nils ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

cell; Insulin mRNA; mRNA stability; Polypyrimidine tract binding protein; siRNA

Indexed keywords

GLUCOSE; INSULIN; INTERLEUKIN 1BETA; POLYPYRIMIDINE TRACT BINDING PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA STABILITY;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INTERLEUKIN-1; ISLETS OF LANGERHANS; MICE; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 12844255845     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.12.147     Document Type: Article

References (18)

1. J. Brunstedt, and S.J. Chan Direct effect of glucose on the preproinsulin mRNA level in isolated pancreatic islets Biochem. Biophys. Res. Commun. 106 1982 1383 1389
2. M. Welsh, D.A. Nielsen, A.J. MacKrell, and D.F. Steiner Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RINm-5F cells J. Biol. Chem. 260 1985 13590 13594
3. L. Tillmar, C. Carlsson, and N. Welsh Control of insulin mRNA stability in rat pancreatic islets J. Biol. Chem. 277 2002 1099 1106
4. B. Wicksteed, T.P. Hebert, C. Alarcon, M.K. Lingohr, L.G. Moss, and C.J. Rhodes Cooperativity between the preproinsulin mRNA untranslated region is necessary for glucose-stimulated translation J. Biol. Chem. 276 2001 22553 22558
5. W.R. Paulding, and M.F. Czyzyk-Krzeska Regulation of tyrosine hydroxylase mRNA stability by protein-binding, pyrimidine-rich sequence in the 3′-untranslated region J. Biol. Chem. 274 1999 2532 2538
6. L. Tillmar, and N. Welsh Hypoxia may increase rat insulin mRNA levels by promoting binding of the polypyrimidine tract-binding protein (PTB) to the pyrimidine-rich insulin mRNA 3′-untranslated region Mol. Med. 8 2002 263 272
7. K.-P. Knoch, H. Bergert, B. Borgonovo, H.-D. Saeger, A. Altkrüger, P. Verkade, and M. Solimena Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis Nat. Cell Biol. 6 2004 207 214
8. Y.L. Oh, B. Hahm, Y.K. Kim, H.K. Lee, J.W. Lee, O. Song, K. Tsukiyama-Kohara, M. Kohara, A. Nomoto, and S.K. Jang Determination of functional domains in polypyrimidine-tract-binding protein Biochem. J. 331 1998 169 175
9. E.J. Wagner, and M.A. Garcia-Blanco Polypyrimidine tract binding protein antagonizes exon definition Mol. Cell. Biol. 21 2001 3281 3288
10. J. Xie, J.-A. Lee, T.L. Kress, K.L. Mowry, and D.L. Black Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein Proc. Natl. Acad. Sci. USA 100 2003 8776 8781
11. G.C. Webb, M.S. Akbar, C. Zhao, and D.F. Steiner Expression profiling of pancreatic β cells: glucose regulation of secretory and metabolic pathway genes Proc. Natl. Acad. Sci. USA 97 2000 5773 5778
12. G.A. Spinas, B.S. Hansen, S. Linde, W. Kastern, J. Molvig, T. Mandrup-Poulsen, C.A. Dinarello, J.H. Nielsen, and J. Nerup Interleukin1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans Diabetologia 30 1987 474 480
13. D.L. Eizirik Interleukin-1 beta induces an early decrease in insulin release, (pro)insulin biosynthesis and insulin mRNA in mouse pancreatic islets by a mechanism dependent on gene transcription and protein synthesis Autoimmunity 10 1991 107 113
14. L. Tillmar, and N. Welsh Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3′-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin Mol. Cell. Biochem. 260 2004 85 90
15. G. da Silva Xavier, J. Rutter, and G.A. Rutter Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose Proc. Natl. Acad. Sci USA 101 2004 8319 8324
16. G. da Silva Xavier, I. Leclerc, I.P. Salt, B. Doiron, D.G. Hardie, A. Kahn, and G.A. Rutter Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression Proc. Natl. Acad. Sci. USA 97 2000 4023 4028
17. B. Kutlu, A.K. Cardozo, M.I. Darville, M. Kruhoffer, N. Magnusson, T. Orntoft, and D.L. Eizirik Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells Diabetes 52 2003 2701 2719
18. M.C. Wollerton, C. Gooding, E.J. Wagner, M.A. Garcia-Blanco, and C.W. Smith Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay Mol. Cell 13 2004 91 100