Regional body fat distribution in HIV-infected patients with lipodystrophy

Journal of Investigative Medicine

Volumn 53, Issue 1, 2005, Pages 15-25

  Dinges, Warren L ^a   Chen, Dali ^a   Snell, Peter G ^a   Weatherall, Paul T ^b   Peterson, Dolores M ^b   Garg, Abhimanyu ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Anthropometry; Body composition; Dual energy x ray absorptiometry; Lipodystrophy; Magnetic resonance imaging

Indexed keywords

ANTIRETROVIRUS AGENT; PROTEINASE INHIBITOR; CHOLESTEROL; FAT; INSULIN; TRIACYLGLYCEROL;

ADULT; ANTHROPOMETRY; ARTICLE; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID STORAGE; LIPODYSTROPHY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; SKINFOLD; WAIST CIRCUMFERENCE; ANTIRETROVIRAL THERAPY; ARM MUSCLE; BICEPS BRACHII MUSCLE; BODY FAT DISTRIBUTION; CHIN; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DIET RESTRICTION; FOREARM; GLUTEUS MUSCLE; HEAD; HIP CIRCUMFERENCE; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HYDRODENSITOMETRY; INSULIN BLOOD LEVEL; INTRAABDOMINAL FAT; MEASUREMENT; MIDDLE AGED; NECK; SKINFOLD THICKNESS; SUBSCAPULARIS MUSCLE; THIGH; THORAX; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WHOLE BODY MRI;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 12744254864     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2005.00001     Document Type: Article

References (60)

1. Chen D, Misra A, Garg A. Lipodystrophy in human immunodeficiency virus-infected patients. J Clin Endocrinol Metab 2002;87:4845-56.
2. Leow MKS, Addy CL, Mantzoros CS. Human immunodeficiency virus/highly active antiretroviral therapy-associated metabolic syndrome: clinical presentation, pathophysiology, and therapeutic strategies. J Clin Endocrinol Metab 2003;88:1961-76.
3. Wanke CA, Falutz JM, Shevitz A, et al. Clinical evaluation and management of metabolic and morphologic abnormalities associated with human immunodeficiency virus. Clin Infect Dis 2002;34:248-59.
4. Kingston MA, Bowman CA. The investigation of patients with HIV infection: 10 years of progress. Int J STD AIDS 2001;12(1):1-7.
5. Shevitz A, Wanke CA, Falutz J, Kotler DP. Clinical perspectives on HIV-associated lipodystrophy syndrome: an update [published erratum appears in AIDS 2002;16:307]. AIDS 2001;15:1917-30.
6. Shevitz A, Wanke CA, Falutz J, Kotler DP. Clinical perspectives on HIV-associated lipodystrophy syndrome: an update [published erratum appears in AIDS 2002;16:307]. AIDS 2001;15:1917-30.
7. Safrin S, Grunfeld C. Fat distribution and metabolic changes in patients with HIV infection. AIDS 1999;13:2493-505.
8. Jain RG, Furfine ES, Pedneault L, et al. Metabolic complications associated with antiretroviral therapy. Antiviral Res 2001;51:151-77.
9. Mallon PW, Cooper DA, Carr A. HIV-associated lipodystrophy. HIV Med 2001;2:166-73.
10. Gan SK, Samaras K, Carr A, Chisholm D. Anti-retroviral therapy, insulin resistance and lipodystrophy. Diabetes Obes Metab 2001;3:67-71.
11. Schwenk A. Methods of assessing body shape and composition in HIV-associated lipodystrophy. Curr Opin Infect Dis 2002;15:9-16.
12. The evaluation of the metabolic complications of H. The evaluation of metabolic function and fat redistribution in clinical trials. HIV Med 2002;3:65-72.
13. Lichtenstein KA, Ward DJ, Moorman AC, et al. Clinical assessment of HIV-associated lipodystrophy in an ambulatory population. AIDS 2001;15:1389-98.
14. Kotler DP, Rosenbaum K, Wang J, Pierson RN. Studies of body composition and fat distribution in HIV-infected and control subjects. J Acquir Immune Defic Syndr Hum Retrovirol 1999;20:228-37.
15. Martinez E, Bianchi L, Garcia-Viejo MA, et al. Sonographic assessment of regional fat in HIV-1-infected people. Lancet 2000;356:1412-3.
16. Lo JC, Mulligan K, Tai VW, et al. "Buffalo hump" in men with HIV-1 infection. Lancet 1998;351:867-70.
17. Carr A, Samaras K, Burton S, et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998;12:F51-8.
18. Carr A, Emery S, Law M, et al. An objective case definition of lipodystrophy in HIV-infected adults: a case-control study. Lancet 2003;361:726-35.
19. Belloso WH, Quiros RE, Ivalo SA, et al. Agreement analysis of variables involved in lipodystrophy syndrome definition in HIV-infected patients. J Acquir Immune Defic Syndr 2003;32:104-11.
20. Engelson ES, Kotler DP, Tan Y, et al. Fat distribution in HIV-infected patients reporting truncal enlargement quantified by whole-body magnetic resonance imaging. Am J Clin Nutr 1999;69:1162-9.
21. Brambilla P, Bricalli D, Sala N, et al. Highly active antiretroviral-treated HIV-infected children show fat distribution changes even in absence of lipodystrophy. AIDS 2001;15:2415-22.
22. Carr A, Workman C, Smith DE, et al. Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy: a randomized trial. JAMA 2002;288:207-15.
23. Rietschel P, Hadigan C, Corcoran C, et al. Assessment of growth hormone dynamics in human immunodeficiency virus-related lipodystrophy. J Clin Endocrinol Metab 2001;86:504-10.
24. Carr A, Miller J, Law M, Cooper DA. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 2000;14(3):F25-32.
25. Huang JS, Rietschel P, Hadigan CM, et al. Increased abdominal visceral fat is associated with reduced bone density in HIV-infected men with lipodystrophy. AIDS 2001;15:975-82.
26. Saint-Marc T, Partisani M, Poizot-Martin I, et al. Fat distribution evaluated by computed tomography and metabolic abnormalities in patients undergoing antiretroviral therapy: preliminary results of the LIPOCO study. AIDS 2000;14:37-49.
27. Carr A, Hudson J, Chuah J, et al. HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study. AIDS 2001;15:1811-22.
28. Carr A, Miller J, Eisman JA, Cooper DA. Osteopenia in HIV-infected men: association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy. AIDS 2001;15:703-9.
29. Kosmiski LA, Kuritzkes DR, Lichtenstein KA, et al. Fat distribution and metabolic changes are strongly correlated and energy expenditure is increased in the HIV lipodystrophy syndrome. AIDS 2001;15:1993-2000.
30. Ruiz L, Negredo E, Domingo P, et al. Antiretroviral treatment simplification with nevirapine in protease inhibitor-experienced patients with HIV-associated lipodystrophy: 1-year prospective follow-up of a multicenter, randomized, controlled study. J Acquir Immune Defic Syndr 2001;27:229-36.
31. Mulligan K, Grunfeld C, Tai VW, et al. Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immune Defic Syndr 2000;23:35-43.
32. Mulligan K, Tai VW, Algren H, et al. Altered fat distribution in HIV-positive men on nucleoside analog reverse transcriptase inhibitor therapy. J Acquir Immune Defic Syndr 2001;26:443-8.
33. +-lymphocyte percentage at baseline and use of protease inhibitors and stavudine. J Acquir Immune Defic Syndr 2001;27:30-4.
34. Meininger G, Hadigan C, Laposata M, et al. Elevated concentrations of free fatty acids are associated with increased insulin response to standard glucose challenge in human immunodeficiency virus-infected subjects with fat redistribution. Metab Clin Exp 2002;51:260-6.
35. Mynarcik DC, McNurlan MA, Steigbigel RT, et al. Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy. J Acquir Immune Defic Syndr 2000;25:312-21.
36. Carter VM, Hoy JF, Bailey M, et al. The prevalence of lipodystrophy in an ambulant HIV-infected population: it all depends on the definition. HIV Med 2001;2:174-80.
37. Gervasoni C, Ridolfo AL, Trifiro G, et al. Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy. AIDS 1999;13:465-71.
38. Hadigan C, Miller K, Corcoran C, et al. Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 1999;84:1932-7.
39. Carr A, Samaras K, Thorisdottir A, et al. Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 1999;353:2093-9.
40. Mallal SA, John M, Moore CB, et al. Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection. AIDS 2000;14:1309-16.
41. Tsekes G, Chrysos G, Douskas G, et al. Body composition changes in protease inhibitor-naive HIV-infected patients treated with two nucleoside reverse transcriptase inhibitors. HIV Med 2002;3:85-90.
42. Miller KD, Jones E, Yanovski JA, et al. Visceral abdominal-fat accumulation associated with use of indinavir. Lancet 1998;351:871-5.
43. Andrade S, Lan SJ, Engelson ES, et al. Use of a Durnin-Womersley formula to estimate change in subcutaneous fat content in HIV-infected subjects. Am J Clin Nutr 2002;75:587-92.
44. Boren HG, Kory KC, Syner JC. The Veterans' Administration-Army cooperative study of pulmonary function: II. Am J Med 1966;41:96-114.
45. Black LF, Offord K, Hyatt RE. Variability in the maximal expiratory flow volume curve in asymptomatic smokers and in nonsmokers. Am Rev Respir Dis 1974;110:282-92.
46. Schutte JE, Townsend EJ, Hugg J, et al. Density of lean body mass is greater in blacks than in whites. J Appl Physiol Respir Environ Exerc Physiol 1984;56:1647-9.
47. Siri WE. The gross composition of the body. In: Tobias CA, Lawrence JH, editors. Advances in biological and medical physics. Vol 4. New York: Academic: 1956. p. 262-9.
48. Abate N, Garg A, Coleman R, et al. Prediction of total subcutaneous abdominal, intraperitoneal, and retroperitoneal adipose tissue masses in men by a single axial magnetic resonance imaging slice. Am J Clin Nutr 1997;65:403-8.
49. Heymsfield SB, Wang Z, Baumgartner RN, Ross R. Human body composition: advances in models and methods. Annu Rev Nutr 1997;17:527-58.
50. Mazess RB, Trempe JA, Bisek JR et al. Calibration of dual-energy x-ray absorptiometry for bone density. J Bone Miner Res 1991;6:799-806.
51. Mazess RB, Barden HS, Bisek JP, Hanson J. Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr 1990;51:1106-12.
52. Baumgartner RN, Heymsfield SB, Roche AF, Bernardino M. Abdominal composition quantified by computed tomography. Am J Clin Nutr 1988;48:936-45.
53. Seidell JC, Bakker CJ, van derKooy K. Imaging techniques for measuring adipose-tissue distribution-a comparison between computed tomography and 1.5-T magnetic resonance. Am J Clin Nutr 1990;51:953-7.
54. Abate N, Burns D, Peshock RM, et al. Estimation of adipose tissue mass by magnetic resonance imaging: validation against dissection in human cadavers. J Lipid Res 1994;35:1490-6.
55. Gronemeyer SA, Steen RG, Kauffman WM, et al. Fast adipose tissue (FAT) assessment by MRI. Magn Reson Imaging 2000;18:815-8.
56. Borkan GA, Gerzof SG, Robbins AH, et al. Assessment of abdominal fat content by computed tomography. Am J Clin Nutr 1982;36:172-7.
57. Kvist H, Chowdhury B, Grangard U, et al. Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations. Am J Clin Nutr 1988;48:1351-61.
58. Shen W, Wang Z, Punyanita M, et al. Adipose tissue quantification by imaging methods: a proposed classification. Obes Res 2003;11:5-16.
59. Saint-Marc T, Partisani M, Poizot-Martin I, et al. A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy. AIDS 1999;13:1659-67.
60. Thoni GJ, Fedou C, Brun JF, et al. Reduction of fat accumulation and lipid disorders by individualized light aerobic training in human immunodeficiency virus infected patients with lipodystrophy and/or dyslipidemia. Diabetes Metab 2002;28:397-404.