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Volumn 66, Issue 3, 1996, Pages 898-907

Role of PC2 in proenkephalin processing: Antisense and overexpression studies

Author keywords

Antisense; AtT 20; Enkephalin; Opioid peptide; PC1; PC2; Proenkephalin; Prohormone convertase; Rin

Indexed keywords

COMPLEMENTARY DNA; ENKEPHALIN DERIVATIVE; ENZYME; PROENKEPHALIN;

EID: 0030064542     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66030898.x     Document Type: Article
Times cited : (38)

References (31)
  • 1
    • 0025762119 scopus 로고
    • PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
    • Benjannet S., Rondeau N., Day R., Chretien M., and Seidah N. G. (1991) PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc. Natl. Acad. Sci. USA 88, 3564-3568.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3564-3568
    • Benjannet, S.1    Rondeau, N.2    Day, R.3    Chretien, M.4    Seidah, N.G.5
  • 2
    • 0023036888 scopus 로고
    • Characterization of the molecular forms of proenkephalin in bovine adrenal medulla and rat adrenal, brain and spinal cord with a site-directed antiserum
    • Birch N. P. and Christie D. L. (1986) Characterization of the molecular forms of proenkephalin in bovine adrenal medulla and rat adrenal, brain and spinal cord with a site-directed antiserum. J. Biol. Chem. 261, 12213-12221.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12213-12221
    • Birch, N.P.1    Christie, D.L.2
  • 3
    • 0026398206 scopus 로고
    • Prohormone converting enzymes: Regulation and evaluation of function using antisense RNA
    • Bloomquist B. T., Eipper B. A., and Mains R. E. (1991) Prohormone converting enzymes: regulation and evaluation of function using antisense RNA. Mol. Endocrinol 5, 2014-2024.
    • (1991) Mol. Endocrinol , vol.5 , pp. 2014-2024
    • Bloomquist, B.T.1    Eipper, B.A.2    Mains, R.E.3
  • 4
    • 0027765503 scopus 로고
    • Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin
    • Breslin M. B., Lindberg I., Benjannet S., Mathis J. P., Lazure C., and Seidah N. G. (1993) Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin. J. Biol. Chem. 268, 27084-27093.
    • (1993) J. Biol. Chem. , vol.268 , pp. 27084-27093
    • Breslin, M.B.1    Lindberg, I.2    Benjannet, S.3    Mathis, J.P.4    Lazure, C.5    Seidah, N.G.6
  • 5
    • 0027162728 scopus 로고
    • Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA
    • Day N. C., Lin H., Ueda Y., Meador-Woodruff J. H., and Akil H. (1993) Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA. Neuropeptides 24, 253-262.
    • (1993) Neuropeptides , vol.24 , pp. 253-262
    • Day, N.C.1    Lin, H.2    Ueda, Y.3    Meador-Woodruff, J.H.4    Akil, H.5
  • 6
    • 0002330854 scopus 로고
    • Cationic liposome-mediated transfection
    • Feigner P. L. and Holm M. (1989) Cationic liposome-mediated transfection. Focus 11, 21-25.
    • (1989) Focus , vol.11 , pp. 21-25
    • Feigner, P.L.1    Holm, M.2
  • 7
    • 0026499191 scopus 로고
    • The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans
    • Guest P. C., Arden S. D., Bennett D. L., Clark A., Ruthford N. G., and Hutton J. C. (1992) The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans. J. Biol. Chem. 267, 22401-22406.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22401-22406
    • Guest, P.C.1    Arden, S.D.2    Bennett, D.L.3    Clark, A.4    Ruthford, N.G.5    Hutton, J.C.6
  • 8
    • 0027957282 scopus 로고
    • Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT-20 cells
    • Irminger J. C., Vollenweider F. M., Neerman-Arbez M., and Halban P. A. (1994) Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT-20 cells. J. Biol. Chem. 269, 1756-1762.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1756-1762
    • Irminger, J.C.1    Vollenweider, F.M.2    Neerman-Arbez, M.3    Halban, P.A.4
  • 9
    • 0025002073 scopus 로고
    • Electrophoretic analysis of proteinases in sodium dodecyl sulfate-polyacrylamide gels containing copolymerized radiolabeled protein substrates: Application to proenkephalin processing enzymes
    • Irvine J. W., Roberts S. F., and Lindberg I. (1990) Electrophoretic analysis of proteinases in sodium dodecyl sulfate-polyacrylamide gels containing copolymerized radiolabeled protein substrates: application to proenkephalin processing enzymes. Anal. Biochem. 190, 141-146.
    • (1990) Anal. Biochem. , vol.190 , pp. 141-146
    • Irvine, J.W.1    Roberts, S.F.2    Lindberg, I.3
  • 10
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 11
    • 0027275151 scopus 로고
    • Tissue-specific and substrate-specific endoproteolytic cleavage of monkey proopiomelanocortin in heterologous endocrine cells: Processing at Lys-Lys dibasic pairs
    • Lin H., Day N. C., Udea Y , Martin D. K., Dixon J. E., Seidah N. G., and Akil H. (1993) Tissue-specific and substrate-specific endoproteolytic cleavage of monkey proopiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs. Neuroendocrinology 58, 94-105.
    • (1993) Neuroendocrinology , vol.58 , pp. 94-105
    • Lin, H.1    Day, N.C.2    Udea, Y.3    Martin, D.K.4    Dixon, J.E.5    Seidah, N.G.6    Akil, H.7
  • 12
    • 0022878758 scopus 로고
    • Reserpine-induced alterations in the processing of proenkephalin in cultured chromaffin cells
    • Lindberg I. (1986) Reserpine-induced alterations in the processing of proenkephalin in cultured chromaffin cells. J. Biol. Chem. 261, 16317-16322.
    • (1986) J. Biol. Chem. , vol.261 , pp. 16317-16322
    • Lindberg, I.1
  • 13
    • 0021756986 scopus 로고
    • 8-immunoreactive peptides in rat brain: Presence of multiple molecular forms
    • 8-immunoreactive peptides in rat brain: presence of multiple molecular forms. Brain Res. 299, 73-78.
    • (1984) Brain Res. , vol.299 , pp. 73-78
    • Lindberg, I.1    Yang, H.-Y.T.2
  • 14
    • 0025797573 scopus 로고
    • Posttranslational modifications of rat proenkephalin overexpressed in Chinese hamster ovary cells
    • Lindberg I., Shaw E., Finley J., Leone D., and Deininger P. (1991) Posttranslational modifications of rat proenkephalin overexpressed in Chinese hamster ovary cells. Endocrinology 128, 1849-1856.
    • (1991) Endocrinology , vol.128 , pp. 1849-1856
    • Lindberg, I.1    Shaw, E.2    Finley, J.3    Leone, D.4    Deininger, P.5
  • 15
    • 0029022254 scopus 로고
    • Enzymatic characterization of immunopurified prohormone convertase 2: Potent inhibition by a 7B2 peptide fragment
    • Lindberg I., van den Hurk W., Bui C., and Batie C. (1995) Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment. Biochemistry 34, 5486-5493.
    • (1995) Biochemistry , vol.34 , pp. 5486-5493
    • Lindberg, I.1    Van Den Hurk, W.2    Bui, C.3    Batie, C.4
  • 16
    • 0025831247 scopus 로고
    • Expression and post-translational processing of gastrin in heterologous endocrine cells
    • Marino L. R., Takeuchi T., Dickinson C. J., and Yamada T. (1991) Expression and post-translational processing of gastrin in heterologous endocrine cells. J. Biol. Chem. 266, 6133-6136.
    • (1991) J. Biol. Chem. , vol.266 , pp. 6133-6136
    • Marino, L.R.1    Takeuchi, T.2    Dickinson, C.J.3    Yamada, T.4
  • 17
    • 0026463542 scopus 로고
    • Posttranslational processing of proenkephalin in AtT-20 cells: Evidence for cleavage at a Lys-Lys site
    • Mathis J. P. and Lindberg I. (1992) Posttranslational processing of proenkephalin in AtT-20 cells: evidence for cleavage at a Lys-Lys site. Endocrinology 131, 2287-2296.
    • (1992) Endocrinology , vol.131 , pp. 2287-2296
    • Mathis, J.P.1    Lindberg, I.2
  • 18
    • 0028314540 scopus 로고
    • Processing of proenkephalin in bovine chromaffin cells occurs in two phases
    • Rostovtsev A. P. and Wilson S. P. (1994) Processing of proenkephalin in bovine chromaffin cells occurs in two phases. Mol. Cell. Endocrinol. 101, 277-285.
    • (1994) Mol. Cell. Endocrinol. , vol.101 , pp. 277-285
    • Rostovtsev, A.P.1    Wilson, S.P.2
  • 20
    • 0025622849 scopus 로고
    • cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: Tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
    • Seidah N. G., Gaspar L., Marcinkiewicz M., Mbikay M., and Chretien M. (1990)cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA Cell Biol. 9, 415-424.
    • (1990) DNA Cell Biol. , vol.9 , pp. 415-424
    • Seidah, N.G.1    Gaspar, L.2    Marcinkiewicz, M.3    Mbikay, M.4    Chretien, M.5
  • 21
    • 0025803098 scopus 로고
    • Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, furin and Kex2: Distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2
    • Seidah N. G., Marcinkiewicz M., Benjannet S , Gaspar L., Beaubien G., Mattei M. G., Lazure C., Mbikay M., and Chretien M. (1991) Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, furin and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol. Endocrinol. 5, 111-122.
    • (1991) Mol. Endocrinol. , vol.5 , pp. 111-122
    • Seidah, N.G.1    Marcinkiewicz, M.2    Benjannet, S.3    Gaspar, L.4    Beaubien, G.5    Mattei, M.G.6    Lazure, C.7    Mbikay, M.8    Chretien, M.9
  • 22
    • 0027404880 scopus 로고
    • Gene expression of prohormone and proprotein convertases in rat CNS: A comparative in situ hybridization analysis
    • Schafer M. K. H., Day R., Cullinan W., Chretien M., Seidah N., and Warson S. (1993) Gene expression of prohormone and proprotein convertases in rat CNS: a comparative in situ hybridization analysis. J. Neurosci. 13, 1258-1279.
    • (1993) J. Neurosci. , vol.13 , pp. 1258-1279
    • Schafer, M.K.H.1    Day, R.2    Cullinan, W.3    Chretien, M.4    Seidah, N.5    Warson, S.6
  • 23
    • 0027436437 scopus 로고
    • Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells
    • Shen F., Seidah N. G., and Lindberg I. (1993) Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells. J. Biol. Chem. 268, 24910-24915
    • (1993) J. Biol. Chem. , vol.268 , pp. 24910-24915
    • Shen, F.1    Seidah, N.G.2    Lindberg, I.3
  • 24
    • 0025214491 scopus 로고
    • Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
    • Smeekens S. P. and Steiner D. F. (1990) Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J. Biol. Chem. 265, 2997-3000.
    • (1990) J. Biol. Chem. , vol.265 , pp. 2997-3000
    • Smeekens, S.P.1    Steiner, D.F.2
  • 25
    • 0026088633 scopus 로고
    • Identification of a cDNA encoding a second putative convertase related to PC2 in AtT-20 cells and islets of Langerhans
    • Smeekens S. P., Avruch A. S., LaMendola J., Chan S. J., and Steiner D. F. (1990) Identification of a cDNA encoding a second putative convertase related to PC2 in AtT-20 cells and islets of Langerhans. Proc. Natl. Acad. Sci. USA 88, 340-344.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 340-344
    • Smeekens, S.P.1    Avruch, A.S.2    LaMendola, J.3    Chan, S.J.4    Steiner, D.F.5
  • 26
    • 0025945724 scopus 로고
    • Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: Evidence for a common core of neuroendocrine processing enzymes
    • Thomas L., Leduc R., Thorne B. A., Smeekens S. P., Steiner D. F., and Thomas G. (1991) Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Proc. Natl. Acad. Sci. USA 88, 5297-5301.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5297-5301
    • Thomas, L.1    Leduc, R.2    Thorne, B.A.3    Smeekens, S.P.4    Steiner, D.F.5    Thomas, G.6
  • 27
    • 0024519427 scopus 로고
    • Expression of mouse proopiomelanocortin in an insulinoma cell line
    • Thorne B. A., Caton L. W., and Thomas G. (1989) Expression of mouse proopiomelanocortin in an insulinoma cell line. J. Biol. Chem. 264, 3545-3552.
    • (1989) J. Biol. Chem. , vol.264 , pp. 3545-3552
    • Thorne, B.A.1    Caton, L.W.2    Thomas, G.3
  • 28
    • 0020537507 scopus 로고
    • Biochemistry of the enkephalins and enkephalin-containing peptides
    • Udenfriend S. and Kilpatrick D. L. (1983) Biochemistry of the enkephalins and enkephalin-containing peptides. Arch. Biochem. Biophys. 221, 309-323.
    • (1983) Arch. Biochem. Biophys. , vol.221 , pp. 309-323
    • Udenfriend, S.1    Kilpatrick, D.L.2
  • 29
    • 0026353201 scopus 로고
    • Processing of proenkephalin in adrenal chromaffin cells
    • Wilson S. P. (1991) Processing of proenkephalin in adrenal chromaffin cells. J. Neurochem. 57, 876-881.
    • (1991) J. Neurochem. , vol.57 , pp. 876-881
    • Wilson, S.P.1
  • 30
    • 0027488373 scopus 로고
    • The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing
    • Zhou A., Bloomquist B. T., and Mains R. E. (1993) The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing. J. Biol. Chem. 268, 11763-11769.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11763-11769
    • Zhou, A.1    Bloomquist, B.T.2    Mains, R.E.3
  • 31
    • 0029075455 scopus 로고
    • 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity
    • Zhu X. and Lindberg I. (1995) 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. J. Cell Biol. 129, 1641-1650.
    • (1995) J. Cell Biol. , vol.129 , pp. 1641-1650
    • Zhu, X.1    Lindberg, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.