Effect of Moderate Acute Exercise on Expression of mRNA Involved in the Calcineurin Signaling Pathway in Human Skeletal Muscle

IUBMB Life

Volumn 55, Issue 7, 2003, Pages 409-413

  Hitomi, Yoshiaki ^a   Kizaki, Takako ^a   Katsumura, Toshihito ^b   Mizuno, Masao ^c   Itoh, Choh Ei ^a   Esaki, Kazuki ^d   Fujioka, Yasunori ^a   Takemasa, Tohru ^d   Haga, Shukoh ^d   Ohno, Hideki ^a  

^a KYORIN UNIVERSITY   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c University of Esbjerg   (Denmark)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

C fos; Calcineurin; Exercise; MRNA expression; NFAT

Indexed keywords

CALCINEURIN; CALCIUM; MESSENGER RNA; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENRICHED CALCINEURIN INTERACTING PROTEIN 1; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN; PROTEIN C FOS; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BICYCLE ERGOMETER; DEPHOSPHORYLATION; EXERCISE; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MUSCLE BIOPSY; NORMAL HUMAN; ONCOGENE C FOS; OXYGEN CONSUMPTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SLOW MUSCLE; VASTUS LATERALIS MUSCLE;

CALCINEURIN; DNA-BINDING PROTEINS; EXERCISE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCLES; MYOGENIC REGULATORY FACTORS; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; OXYGEN; PROTO-ONCOGENE PROTEINS C-FOS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EUKARYOTA;

EID: 12444336881     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540310001592825     Document Type: Article

References (16)

1. Pette, D. (2001) Historical Perspectives: plasticity of mammalian skeletal muscle. J. Appl. Physiol. 90, 1119-1124.
2. Chin, E. R., Olson, E. N., Richardson, J. A., Yang, Q., Humphries, C., Shelton, J. M., Wu, H., Zhu, W., Bassel-Duby, R., and Williams, R. S. (1998) A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes. Dev. 12, 2499-2509.
3. Olson, E. N., and Williams, R. S. (2000) Calcineurin signaling and muscle remodeling. Cell. 101, 689-692.
4. Rao, A., Luo, C., and Hogan, P. G.. (1997) Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747.
5. Wu, H., Rothermel, B., Kanatous, S., Rosenberg, P., Naya, F. J., Shelton, J. M., Hutcheson, K. A., DiMaio, J. M., Olson, E. N., Bassel-Duby, R., and Williams, R. S. (2001) Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. EMBO J, 20, 6414-6423.
6. Wu, H., Naya, F. J., McKinsey, T, A., Mercer, B., Shelton, J. M., Chin, E, R., Simard, A, R., Michel, R. N., Bassel-Duby, R., Olson, E. N., and Williams, R. S, (2000) MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO J. 19, 1963-1973.
7. Macian, F., Lopez Rodriguez, C., and Rao, A. (2001) Partners in transcription: NFAT and AP-1. Oncogene 20, 2476-2489.
8. Rothermel, B., Vega, R. B., Yang, J., Wu, H., Bassel-Duby, R., and Williams, R. S. (2000) A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 275, 8719-8725.
9. Pestronk, G. J., Kaiser, K. K., and Brooke, M. H. (1992) ATPase stain in muscle histochemistry. Muscle. Nerve. 15, 258.
10. Chomczynski, P., and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
11. Puntschart, A., Wey, E., Jostarndt, K., Vogt, M., Wittwer, M., Widmer, H. R., Hoppeler, H., and Billeter, R. (1998) Expression of fos and jun genes in human skeletal muscle after exercise. Am. J. Physiol. 274, C129-137.
12. Jain, J., McCaffrey, P. G., Miner, Z., Kerppola, T. K., Lambert, J. N., Verdine, G. L., Curran, T., and Rao, A. (1993) The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365, 352-355.
13. Masuda, E. S., Naito, Y., Tokumitsu, H., Campbell, D., Saito, F., Hannum, C., Arai, K., and Arai, N. (1995) NFATx, a novel member of the nuclear factor of activated T cells family that is expressed redominantly in the thymus. Mol. Cell. Biol. 15, 2697-2706.
14. Lopez Rodriguez, C., Aramburu, J., Rakeman, A. S., and Rao, A. (1999) NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc. Natl. Acad. Sci. USA. 96, 7214-7219.
15. Pilegaard, H., Saltin, B., and Neufer, P. D. (2003) Exercise induces transient transcriptional activation of the PGC-1 a gene in human skeletal muscle. J. Physiol. 546, 851-858.
16. Rusnak, F., and Mertz, P. (2000) Calcineurin: form and function. Physiol. Rev. 80, 1483-1521.