Pharmacophore identification of α1A-adrenoceptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 3, 2005, Pages 657-664

  Li, Min Yong ^a   Tsai, Keng Chang ^b   Xia, Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

1A Adrenoceptor; Antagonists; Pharmacophore

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE METHYL ESTER; 2 (2 AMINOETHOXYMETHYL) 6 ETHYL 1,4 DIHYDRO 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 AMIDE 3 [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 3 [2 (2,3,3A,4,5,9B HEXAHYDRO 6 METHOXY 1H BENZ[E]ISOINDOL 2 YL)ETHYL]PYRIDO[3',4':4,5]THIENO[3,2 D]PYRIMIDINE 2,4(1H,3H) DIONE; 3 [3 [4 [4 FLUORO 2 (2,2,2 TRIFLUOROETHOXY)PHENYL] 1 PIPERAZINYL]PROPYL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 3 [N [2 (4 HYDROXY 2 ISOPROPYL 5 METHYLPHENOXY)ETHYL] N METHYLAMINOMETHYL] 4 METHOXY 2,5,6 TRIMETHYLPHENOL; 4 (3,4 DIFLUOROPHENYL) 6 ETHYL 3,4 DIHYDRO 2(1H) OXO 3,5 PYRIMIDINEDICARBOXYLIC ACID 5 AMIDE 3 [3 (4 METHOXYCARBONYL 4 PHENYL 1 PIPERIDINYL)PROPYL]AMIDE; 4 AMINO 2 [4 BENZYLOXYCARBONYL 3 [(TERT BUTYLAMINO)CARBONYL] 1 PIPERAZINYL] 6,7 DIMETHOXYQUINAZOLINE; 5 CHLORO N [2 (2 CYCLOPROPYLMETHOXYPHENOXY)ETHYL] ALPHA,ALPHA DIMETHYL 1H INDOLE 3 ETHANAMINE; 5 METHYL 3 [3 [4 [2 (2,2,2 TRIFLUOROETHOXY)PHENYL] 1 PIPERAZINYL]PROPYL] 1H PYRIMIDINE 2,4 DIONE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; A 119637; A 123189; A 315456; AH 11110A; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1A ADRENERGIC RECEPTOR ANTAGONIST; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BENOXATHIAN; CORYNANTHINE; DISCRETAMINE; DOMESTICINE; L 771688; NAFTOPIDIL; NIGULDIPINE; RISPERIDONE; RO 1104253; RS 513815; RWJ 38063; RWJ 68141; RWJ 68157; RWJ 69736; SILODOSIN; SKF 105854; SL 890591; SNAP 5036; SNAP 5051; SNAP 7915; SNAP 8719; SPIPERONE; TAMSULOSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; MOLECULAR MODEL; PHARMACOPHORE;

ADRENERGIC ALPHA-ANTAGONISTS; DRUG EVALUATION, PRECLINICAL; EXPERT SYSTEMS; HUMANS; MODELS, MOLECULAR; RECEPTORS, ADRENERGIC, ALPHA-1; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12444300063     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.11.032     Document Type: Article

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