Improvement of growth and camptothecin yield by altering nitrogen source supply in cell suspension cultures of Camptotheca acuminata

Biotechnology Letters

Volumn 26, Issue 22, 2004, Pages 1745-1748

  Pan, Xue Wu ^a   Xu, Heng Hao ^a   Liu, Xin ^a   Gao, Xiang ^a   Lu, Ying Tang ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Ammonium; Camptotheca acuminata; Camptothecin; Nitrate; Two stage culture

Indexed keywords

BIOMASS; GROWTH KINETICS; NITRATES; SUSPENSIONS (FLUIDS);

CAMPTOTHECA ACUMINATA; CAMPTOTHECIN; MOLAR RATIO;

CELL CULTURE;

CAMPTOTHECIN;

ARTICLE; BIOSYNTHESIS; CAMPTOTHECA; CELL LINE; CELL PROLIFERATION; CULTURE TECHNIQUE; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY;

CAMPTOTHECA; CAMPTOTHECIN; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION;

CAMPTOTHECA; CAMPTOTHECA ACUMINATA;

EID: 12444257809     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10529-004-4580-2     Document Type: Article

References (19)

1. Bensaddek L, Gillet F, Saucedo JEN, Fliniaux M (2001) The effect of nitrate and ammonium concentrations on growth and alkaloid accumulation of Atropa belladonna hairy roots. J. Biotechnol. 85: 35-40.
2. Chen YC, Yi F, Cai M, Luo JX (2003) Effects of amino acids, nitrate, and ammonium on the growth and taxol production in cell cultures of Taxus yunnanensis. Plant Growth Regul. 41: 265-268
3. Ciddi V, Shuler ML (2000) Camptothecin from callus cultures of Nothapodytes foetida. Biotechnol. Lett. 22: 129-132.
4. Crawford NM (1995) Nitrate: nutrient and signal for plant growth. Plant Cell 7: 859-868.
5. Du W (2003) Towards new anticancer drugs: a decade of advances in synthesis of camptothecins and related alkaloids. Tetrahedron 59: 8649-8687.
6. Fulzele DP, Satdive RK, Pol BB (2002) Untransformed root cultures of Nothapodytes foetida and production of camptothecin. Plant Cell Tiss. Org. Cult. 69: 285-288.
7. Hsiang YH, Hertzberg R, Hecht S, Liu LF (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260: 14873-14878.
8. Hung CL, Doniger J, Palini A, Snyder SW, Radonovich MF, Brady JN, Pantazis P, Reza Sadaie M (2001) 9-Nitrocamptothecin inhibits HIV-1 replication in human peripheral blood lymphocytes: a potential alternative for HIV-infection/AIDS therapy. J. Med. Virol. 64: 238-244.
9. Li ZH (2002) Effects of several abiotic and biotic factors and plant hormones on growth, morphology, and camptothecin accumulation in Camptotheca acuminata seedlings. Ph.D. Thesis, Louisiana State University, USA.
10. Lorence A, Medina-Bolivar F, Nessler CL (2004) Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots. Plant Cell Rep. 22: 437-441.
11. Moreno PRH, van der Heijden R, Verpoorte R (1995) Cell and tissue cultures of Catharanthus roseus: a literature survey II. Updating from 1998 to 1993. Plant Cell Tiss. Org. Cult. 42: 1-25.
12. Pan XW, Shi YY, Liu X, Gao X, Lu YT Influence of inorganic microelements on the production of camptothecin with suspension cultures of Camptotheca acuminata. Plant Growth Regul. (in press).
13. Panda AK, Mishra S, Bisaria VS (1992) Alkaloid production by plant cell suspension cultures of Holarrhena antidysenterica: I. Effect of major nutrients. Biotechnol. Bioeng. 39: 1043-1051.
14. Sudo H, Yamakawa T, Yamazaki M, Aimi N, Saito K (2002) Bioreactor production of camptothecin by hairy root cultures of Ophiorrhiza pumila. Biotechnol. Lett. 24: 359-363.
15. Thengane SR, Kulkarni DK, Shrikhande VA, Joshi SP, Sonawane KB, Krishnamurthy KV (2003) Influence of medium composition on callus induction and camptothecin(s) accumulation in Nothapodytes foetida. Plant Cell Tiss. Org. Cult. 72: 247-251.
16. Van Hengel AJ, Harkes MP, Wichers HJ, Hesselink PGM, Buitelaar RM (1992) Characterization of callus formation and camptothecin production by cell lines of Camptotheca acuminata. Plant Cell Tiss. Org. Cult. 28: 11-18.
17. Wall ME, Wani MC, Cook CE, Palmer KH (1966) Plant antitumor agents I. The isolation and structure of camptothecin - a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 88: 3888-3890.
18. Wiedenfeld H, Furmanowa M, Roeder E, Guzewska J, Gustowski H (1997) Camptothecin and 10-hydroxycamptothecin in callus and plantlets of Camptotheca acuminata. Plant Cell Tiss. Org. Cult. 49: 213-218.
19. 13C]glucose. Plant Physiol. 134: 161-170.