Deferoxamine interferes with adhesive functions of activated human neutrophils

Shock

Volumn 5, Issue 6, 1996, Pages 395-401

  Varani, James ^a   Dame, Michael K ^a   Diaz, Myrna ^a   Stoolman, Lloyd ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; 1,10-PHENANTHROLINE; CHELATING AGENT; DEFEROXAMINE; EDETIC ACID; EGTAZIC ACID; HETASTARCH; LEUKOCYTE ELASTASE; METALLOPROTEINASE; PANCREATIC ELASTASE; PHENANTHROLINE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE;

ADULT; ANIMAL; ARTICLE; CELL ADHESION; CELL LINE; CYTOLOGY; DRUG EFFECT; EPITHELIUM; HUMAN; IN VITRO STUDY; LEUKOCYTE ACTIVATION; LUNG; METABOLISM; NEUTROPHIL; RAT; VASCULAR ENDOTHELIUM;

ADULT; ANIMALS; CELL ADHESION; CELL LINE; CHELATING AGENTS; DEFEROXAMINE; EDETIC ACID; EGTAZIC ACID; ENDOTHELIUM, VASCULAR; EPITHELIUM; HETASTARCH; HUMANS; LEUKOCYTE ELASTASE; LUNG; METALLOENDOPEPTIDASES; NEUTROPHIL ACTIVATION; NEUTROPHILS; PANCREATIC ELASTASE; PHENANTHROLINES; RATS; TETRADECANOYLPHORBOL ACETATE;

EID: 0030156703     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199606000-00002     Document Type: Article

References (34)

1. Gutteridge JMC, Richmond R, Halliwell B: Inhibition of the iron-catalyzed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine. Biochem J 184:469-472, 1979.
2. Gannon DE, Varani J, Phan SH, et al: Source of iron in neutrophil-mediated killing of endothelial cells. Lab Invest 57:37-44, 1987.
3. 2-mediated cytotoxicity of rat pulmonary endothelial cells: Changes in adenosine triphosphate and purine products and effects of protective interventions. Lab Invest 63:683-689, 1990.
4. Starke PE, Farber JL: Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide: evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haver-Weiss reaction. J Biol Chem 260:10099-10105, 1985.
5. Redl H, Gasser H, Hallstrom S: Radical related cell injury. In Schlag G, Redl H (eds): Pathophysiology of Shock, Sepsis and Organ Failure. Heidelberg: Springer-Verlag, 1993, pp 92-110.
6. Halliwell B, Gutteridge JMC: Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts. Arch Biochem Biophys 246:501-514, 1986.
7. Varani J, Dame MK, Gibbs DF, et al: Human umbilical vein endothelial cell killing by activated neutraphils: loss of sensitivity to injury is accompanied by decreased iron content during in vitro culture and is restored with exogenous iron. Lab Invest 66:708-712, 1992.
8. Varani J, Dame MK: Injury to adult human dermal microvascular endothelial cells in vitro. Shock 3:179-184, 1995.
9. Taylor CG, Dame MK, Murphy HS, Ward PA, Varani J: Spontaneous injury to human umbilical vein endothelial cells increases during in vitro culture and is blocked by protein kinase C activation. Lab Invest 70:822-829, 1994.
10. Schuger L, Varani J, Marks RM, Kunkel SL, Johnson KJ, Ward PA: Cytotoxicity of tumor necrosis factor-alpha for human umbilical vein endothelial cells. Lab Invest 61:62-67, 1989.
11. Stoolman LS, Ebling E: Adhesion molecules of cultured hematopoietic malignancies: a calcium-dependent lectin is the principle mediator of binding to the high endothelial venule of lymph nodes. J Clin Invest 84:1196-1205.
12. Mulligan MS, Desrochers PE, Chinnaiyan AM, et al: In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinase-2. Proc Natl Acad Sci USA 90:11,523-11,527, 1993.
13. Knight CG, Willenbrock F, Murphy G: A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases FEBS Lett 269:263-266, 1992.
14. Picker LJ, Treer JR, Nguyen M, Terstappen LW, Hogg N, Yednock T: Coordinate expression of beta 1 and beta 2 integrin "activation" epitopes during T cell responses in secondary lymphoid tissue. Eur J Immunol 23:2751-2757, 1993.
15. Dransfield I, Cabanas C, Craig A, Hogg N: Divalent cation regulation of the function of the leukocyte integrin LFA-1. J Cell Biol 116:219-226, 1992.
16. Hallaway PE, Eaton JW, Panter SS: Modulation of deferoxamine toxicity and clearance by covalent attachment to biocompatable polymers. Proc Natl Acad Sci USA 86:10108-10112, 1989.
17. Hershko C, Rachmilewitz EA: Mechanism of action of desferrioxamine-induced chelation in thalassemia. Br J Haematol 42:125-132, 1979.
18. Ward PA, Till G, Kunkel R, Beauchamps C: Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury. J Clin Invest 72:789-795, 1983.
19. Drugas GT, Paidas CN, Yahanda AM: Conjugated deferoxamine attenuates hepatic microvascular injury following ischemia/reperfusion. Circ Shock 34:278-288, 1991.
20. Laionde C, Knox J, Youn YK: Relationship between hepatic blood flow and tissue peroxidation in the early postburn period. Crit Care Med 20:789-796, 1992.
21. Whitley WD, Hancock WW, Kupiec-Weglinski JW, DeSousa M, Tilney NL: Iron chelation suppresses mononuclear cell activation, modifies lymphocyte migration patterns, and prolongs rat cardiac allograft survival in rats. Transplantation 56:1182-1188, 1993.
22. Andreoli SP, McAtter JA: Reactive oxygen molecule-mediated injury in endothelial and renal tubular epithelial cells in vitro. Kidney Int 38:785-794, 1990.
23. Varani J, Taylor CG, Riser B, et al: Mesangial cell killing leukocytes: Role for leukocyte oxidants and proteolytic enzymes. Kidney Int 42:1169-1177, 1992.
24. Sacks T, Moldow CF, Craddock PR, Bower TK, Jacob HS: Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes: An in vitro model of immune vascular damage. J Clin Invest 61:1161-1167, 1978.
25. Balla G, Vercellotti GM, Eaton JW, Jacob HS: Iron-loading of endothelial cells augments oxygen damage. J Lab Clin Med 116:546-550, 1990.
26. Whitley WD, Nancock WW, Kupiec-Weglinski JW, DeSousa M, Tilney NL: Iron chelation suppresses mononuclear cell activation, modifies lymphocyte migration patterns, and prolongs rat cardiac allograft survival in rats. Transplantation 56:1182-1188, 1993.
27. Kuvibidila S, Baliga BS, Murthy KK: Impaired protein kinase C activation as one of the possible mechanisms of reduced lymphocyte proliferation in iron deficiency in mice. Am J Clin Nutr 54:944-950, 1991.
28. 2 integrins of rat neutrophils in complement- and oxygen radical-mediated acute inflammatory injury. J Immunol 148:1847-1857, 1992.
29. Lenker MW, Arroyo R, Alderete JF: The regulation by iron of the synthesis of adhesins and cytoadherence levels in the protozoan Trichomonas vaginalis. J Exp Med 174:311-318, 1991.
30. Sharma MB, Sharma S, Sharma BK: Effect of iron on adhesion of urinary Escherichia coli. Indian J Med Res 87:561-564, 1988.
31. Kirchhofer D, Gailit J, Ruoslahti E, Grzesiak J, Pierschbacher MD: Cation-dependent changes in the binding specificity of the platelet receptor GPIIb/IIIa. J Biol Chem 265:18525-18530, 1990.
32. Kirchhofer D, Grzesiak J, Pierschbacher MD: Calcium as a physiological regulator of integrin-mediated cell adhesion. J Biol Chem 266:4471-4477, 1991.
33. Sheppard LN, Kontoghiorghes GJ: Competition between deferiprone, desferrioxamine and other chelators for iron and effect of other metals. Arzneim-Forsch 43:659-663, 1993.
34. Bauer M, Feucht K, Ziegenfub T, Marzi I: Attenuation of shock-induced hepatic microcirculatory disturbances by the use of a starch-deferoxamine conjugate for resuscitation. Crit Care Med 23:316-322, 1995.