Design, synthesis and in vitro evaluation of novel benzo[b]thiophene derivatives as serotonin N-acetyltransferase (AANAT) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 2, 2003, Pages 119-125

  Mesangeau, C ^a   Yous, S ^a   Chavatte, P ^a   Ferry, G ^b   Audinot, V ^b   Boutin, J A ^b   Delagrange, P ^b   Bennejean, C ^b   Renard, P ^b   Lesieur, D ^a  

^a UNIV LILLE   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Arylalkylamine N acetyltransferase; Benzothiophene; Inhibition; Melatonin; QSAR; Serotonin N acetyltransferase

Indexed keywords

(3 BROMOMETHYL BENZO[B]THIOPHEN 5 YL)CARBOXYLIC ACID METHYL ESTER; (3 CYANOMETHYL BENZO[B]THIOPHEN 5 YL)CARBOXYLIC ACID METHYL ESTER; (3 METHYL BENZO[B]THIOPHEN 5 YL)CARBONITRILE; (3 METHYL BENZO[B]THIOPHEN 5 YL)CARBOXYLIC ACID; (3 METHYL BENZO[B]THIOPHEN 5 YL)CARBOXYLIC ACID METHYL ESTER; (5 AMINO BENZO[B]THIOPHEN 3 YL)ACETONITRILE HYDROCHLORIDE; 2 (5 NITRO BENZO[B]THIOPHEN 5 YL)ETHYLAMINE HYDROCHLORIDE; [3 (2 (BROMOACETYLAMINO)ETHYL) BENZO[B]THIOPHEN 5 YL]CARBOXYLIC ACID; [3 (2 (BROMOACETYLAMINO)ETHYL) BENZO[B]THIOPHEN 5 YL]CARBOXYLIC ACID METHYL ESTER; [3 (2 AMINOETHYL) BENZO[B]THIOPHEN 5 YL]CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE; BENZOTHIOPHENE DERIVATIVE; ENZYME INHIBITOR; MELATONIN; MELATONIN RECEPTOR; N (3 CYANOMETHYL BENZO[B]THIOPHEN 5 YL)METHANESULFONAMIDE; N [2 (5 METHANESULFONYLAMINO BENZO[B]THIOPHEN 3 YL)ETHYL]BROMOACETAMIDE; N [2 (5 NITRO BENZO[B]THIOPHEN 3 YL)ETHYL]BROMOACETAMIDE; N [3 (2 AMINOETHYL) BENZO[B]THIOPHEN 5 YL]METHANESULFONAMIDE HYDROCHLORIDE; N BROMOACETYLTRYPTAMINE; SEROTONIN N ACETYLTRANSFERASE; SEROTONIN N ACETYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SYNTHESIS; EVALUATION; IN VITRO STUDY; OBESITY; PATHOPHYSIOLOGY; PINEAL BODY; PRIORITY JOURNAL; RECEPTOR AFFINITY; SEASONAL AFFECTIVE DISORDER; STRUCTURE ACTIVITY RELATION;

ARYLAMINE N-ACETYLTRANSFERASE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; THIOPHENES;

EID: 12444256023     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636031000093552     Document Type: Article

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