Pyridoxine 5′-phosphate synthase: De novo synthesis of vitamin B 6 and beyond

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1647, Issue 1-2, 2003, Pages 92-97

  Garrido Franco, Mafrta ^a,b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Drug design; Enzyme ligand complex; Open closed transition; PdxJ; Reaction mechanism; Vitamin B6

Indexed keywords

BACTERIAL ENZYME; FUNGAL ENZYME; GENE PRODUCT; ISOENZYME; PHOSPHATE; PYRIDOXINE 5' PHOSPHATE SYNTHASE; PYRIDOXINE DERIVATIVE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN; LIGASE; PYRIDOXAL PHOSPHATE BIOSYNTHETIC PROTEIN, E COLI; PYRIDOXINE;

ASPERGILLUS NIDULANS; BACTERIAL GENE; CATALYST; CIRCOSPORA; CONFERENCE PAPER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; FUNGAL GENE; FUNGUS; NONHUMAN; PDX GENE; PRIORITY JOURNAL; RING CLOSING METATHESIS; SOR1 GENE; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; HUMAN; METABOLISM; REVIEW;

BACTERIAL PROTEINS; BINDING SITES; ESCHERICHIA COLI PROTEINS; HUMANS; LIGASES; VITAMIN B 6;

EID: 1242341226     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-9639(03)00065-7     Document Type: Conference Paper

References (21)

1. Hill R.E., Spenser I.D. Biosynthesis of vitamin B6. Dolphin D., Poulson R., Avramovic O. Vitamin B6, Pyridoxal Phosphate, Part A. 1986;417-476 Wiley Interscience, New York.
2. Tryfiates G.P. Pyridoxal phosphate and metabolism. Dolphin D., Poulson R., Avramovic O. Vitamin B6, Pyridoxal Phosphate, Part B. 1986;421-448 Wiley Interscience, New York.
3. Dempsey W.D. Synthesis of pyridoxal phosphate. Neidhardt F.C., Ingraham J.L., Low K.B., Magasanik B., Schaecter M., Umbarger H.E. Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology. vol. I:1987;539-543 American Society for Microbiology, Washington, DC.
4. Yang Y., Zhao G.S., Winkler M.E. Identification of the pdxK gene that encodes pyridoxine (vitamin B-6) kinase in Escherichia coli K-12. FEMS Microbiol. Lett. 141:1996;89-95.
5. Lam H.-M., Winkler M.E. Characterization of the complex pdxH-TyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations. J. Bacteriol. 174:1992;6033-6045.
6. Roa B.B., Conolly D.M., Winkler M.E. Overlap between pdxA and ksgA in the complex pdxA-ksgA-apaG-apaH operon of Escherichia coli K-12. J. Bacteriol. 171:1989;4767-4777.
7. Schoenlein P.V., Roa B.B., Winkler M.E. Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12. J. Bacteriol. 171:1989;6084-6092.
8. Zhao G., Winkler M.E. Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5′-phosphate oxidase of Escherichia coli K-12. J. Bacteriol. 177:1995;883-891.
9. Notheis C., Drewke C., Leiistner E. Purification and characterisation of the pyridoxol-5′-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli. Biochim. Biophys. Acta. 1247:1995;265-271.
10. Laber B., Maurer W., Scharf S., Stepusin K., Schmidt F.S. Vitamin B-6 biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. FEBS Lett. 449:1999;45-48.
11. Cane D.E., Du S.C., Robinson J.K., Hsiung Y., Spenser I.D. Biosynthesis of vitamin B-6: enzymatic conversion of 1-deoxy-D-xylulose-5-phosphate to pyridoxol phosphate. J. Am. Chem. Soc. 121:1999;7722-7723.
12. Osmani A.H., May G.S., Osmani S.A. The extremely conserved pyroA gene of Aspergillus nidulans is required for Pyridoxine synthesis and is required indirectly for resistance to photosensitizers. J. Biol. Chem. 274:1999;23565-23569.
13. Ehrenshaft M., Jenns A.E., Chung K.R., Daub M.E. SOR1, a gene required for photosensitizer and singlet oxygen resistance in Cercospora fungi is highly conserved in divergent organisms. Mol. Cell. 1:1998;603-609.
14. Ehrenshaft M., Bilski P., Li M.S., Chignell C.F., Daub M.E. A highly conserved sequence is a novel gene involved in de novo vitamin B6 biosynthesis. Proc. Natl. Acad. Sci. 96:1999;9374-9378.
15. Garrido-Franco M., Laber B., Huber R., Clausen T. Structural basis for the function of pyridoxine 5′-phosphate synthase. Structure. 9:2001;245-253.
16. Garrido-Franco M., Laber B., Huber R., Clausen T. Enzyme-ligand complexes of pyridoxine 5′-phosphate synthase: implications for substrate binding and catalysis. J. Mol. Biol. 321:2002;601-612.
17. Cane D.E., Du S., Spenser I.D. Biosynthesis of vitamin B6: origin of the oxygen atoms of pyridoxol phosphate. J. Am. Chem. Soc. 122:2000;4213-4214.
18. Arigoni F., Talabot F., Peitsch M., Edgerton M.D., Meldrum E., Allet E., Fish R., Jamotte T., Curchod M.-L., Loferer H. A genome-based approach for the identification of essential bacterial genes. Nat. Biotechnol. 16:1998;851-856.
19. Kraulis P.J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24:1991;946-950.
20. Merrit E.A., Murphy M.E.P. RASTER3D Version 2.0. A program for photorealistic molecular graphics. Acta Crystallogr., Sect. D. 50:1994;869-873.
21. Evans S.V. Setor - hardware-lighted 3-dimensional solid model representations of macromolecules. J. Mol. Graph. 11:1993;134-141.