Effect of Phosphorothioate Chirality on the Grooves of DNA Double Helices: A Molecular Dynamics Study

Biopolymers

Volumn 73, Issue 2, 2004, Pages 269-282

  Mukherjee, Shayantani ^a   Bhattacharyya, Dhananjay ^a  

^a SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

Author keywords

Cation binding; Chirality; DNA; Drug therapy; Electrostatic energy surfaces; Groove widths; Hydration; Molecular dynamics; Phosphorothioate oligonucleotides

Indexed keywords

COMPUTER SIMULATION; HYDRATION; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; OLIGOMERS; RNA; STEREOCHEMISTRY;

CATION BINDING; CHIRALITY;

DNA;

ANTISENSE OLIGODEOXYNUCLEOTIDE; CATION; DNA; DNA HYBRID; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OLIGOMER; OXYGEN; PHOSPHATE; SULFUR;

ARTICLE; CHIRALITY; DNA BINDING; DNA HELIX; DNA SEQUENCE; ELECTRICITY; ENVIRONMENTAL PARAMETERS; GENE THERAPY; HYDRATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; RNA SEQUENCE; SIMULATION;

BINDING SITES; CATIONS; DNA; ELECTROSTATICS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES, ANTISENSE; ORGANOPHOSPHORUS COMPOUNDS; STEREOISOMERISM; THERMODYNAMICS; THIONUCLEOTIDES; WATER;

EID: 1242340307     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10550     Document Type: Article

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