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Volumn 45, Issue 11, 2004, Pages 2371-2375

Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ALCOHOL DERIVATIVE; MACROGOL; PHENOL DERIVATIVE;

EID: 1242338130     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.01.103     Document Type: Article
Times cited : (13)

References (40)
  • 18
    • 85030899676 scopus 로고    scopus 로고
    • Oikawa, M.; Kiuchi, M.; Vance, J. M.; Schreiber, S. L.; Tallarico, J. A. 44th Tennen Yuki Kagobutsu Toronkai Koen Yoshishu, 2002, 599-604
    • Oikawa, M.; Kiuchi, M.; Vance, J. M.; Schreiber, S. L.; Tallarico, J. A. 44th Tennen Yuki Kagobutsu Toronkai Koen Yoshishu, 2002, 599-604.
  • 19
    • 85030896700 scopus 로고    scopus 로고
    • Purchased from Aldrich Co. (catalog No. 20251-7)
    • Purchased from Aldrich Co. (catalog No. 20251-7).
  • 20
    • 85030905923 scopus 로고    scopus 로고
    • note
    • Density of functional groups of this platform was calculated from the theoretical average molecular weight, 5000 (1), 5014 (2), 5028 (3), 5168 (5), and 5162 (21).
  • 21
    • 85030902510 scopus 로고    scopus 로고
    • Compound 2 can be commercially available from Nektar Therapeutics as its derivatives such as a N-hydroxysuccinimide ester for PEGylation of proteins. The AAc linker has, however, never been directly used as a linker for the PEG support probably because mild cleavage protocol had not been available, see Ref. 19.
  • 29
    • 85030903132 scopus 로고    scopus 로고
    • note
    • 1H NMR using methoxy group of MPEG and methylene group of AAc linker as standards. Recovery yields are based on its weight.
  • 39
    • 0032791397 scopus 로고    scopus 로고
    • For another example of cleavage of esters using Lewis acid catalyst, see:
    • For another example of cleavage of esters using Lewis acid catalyst, see: Kajiro H., Mitamura S., Mori A., Hiyama T. Bull. Chem. Soc. Jpn. 72:1999;1553-1560.
    • (1999) Bull. Chem. Soc. Jpn. , vol.72 , pp. 1553-1560
    • Kajiro, H.1    Mitamura, S.2    Mori, A.3    Hiyama, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.