The Role of Early Infections, Hygiene and Intestinal Microflora

Pediatric Pulmonology

Volumn 37, Issue SUPPL. 26, 2004, Pages 211-212

  Matricardi, Paolo M ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATOPY; CONFERENCE PAPER; DISEASE ASSOCIATION; HELICOBACTER PYLORI; HEPATITIS A VIRUS; HERPES SIMPLEX VIRUS 1; HUMAN; HYGIENE; IMMUNITY; INFECTION; INTESTINE FLORA; PRIORITY JOURNAL; SENSITIZATION; TOXOPLASMA GONDII; ARTICLE; ASTHMA; HEPATITIS A; IMMUNOLOGY; INTESTINE MUCOSA; MICROBIOLOGY; TH1 CELL; TH2 CELL;

ASTHMA; HEPATITIS A; HUMANS; HYGIENE; INTESTINAL MUCOSA; TH1 CELLS; TH2 CELLS;

EID: 1242336908     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/ppul.70108     Document Type: Conference Paper

References (19)

1. Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax 2000;55:S2-S10.
2. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999;354(sII):12-15.
3. Matricardi PM, Rosmini F, Ferrigno L, Nisini R, Rapicetta M., Chionne P, Stroffolini T, Pasquini P, D'Amelio R. Cross-sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. Brit Med J 1997;314:999-1003.
4. Matricardi PM, Rosmini F, Riondino S, Fortini M, Ferrigno L, Rapicetta M, Bonini S. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. Brit Med J 2000;320:412-17.
5. Linneberg A, Ostergaard C, Tvede M, Andersen LP, Nielsen NH, Madsen F, Frolund L, Dirksen A, Jorgensen T. IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy Study. J Allergy Clin Immunol. 2003;111:847-53.
6. Matricardi PM, Rosmini F, Panetta V, Ferrigno L, Bonini S. Hay fever and asthma in relation to markers of infection in the United States. J Allergy Clin Immunol 2002;110:381-87.
7. Romagnani, S. Regulation of the development of type 2 T-helper cells in allergy. Curr Opin Immunol 1994;6:838-46.
8. Yazdanbakhsh M, Kremsner PG, van Ree R. Allergy, parasites and the hygiene hypothesis. Science 2002;296:490-4.
9. McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2001;2:1109-16,
10. McIntire JJ, Umetsu SE, Macaubas C, Hoyte EG, Cinnioglu C, Cavalli-Sforza LL, Barsh GS, Hallmayer JF, Underhill PA, Risch NJ, Freeman GJ, De Kruyff RH, Umetsu DT. Hepatitis A virus link to atopic disease. Nature 2003;425:576.
11. Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, von Mutius E. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001;358:1129-32.
12. Von Ehrenstein OS, von Mutius E, Illi S, Baumann L, Bohm O, and von Kries R. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 2000;30:187-93.
13. Braun-Fahrlander C, Riedler J. Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, Lauener RP, Schierl R, Renz H, Nowak D, von Mutius E. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347:869-77.
14. Sepp E, Julge K, Vasar M, Naaber P, Bjorksten B, Mikkelsaar M. Intestinal microflora of Estonian and Swedish infants. Acta Paediatr 1997;86:956-61.
15. Adlerberth I, Carlsson B, de Man P, Jalil F, Khan SR, Larsson P, Mellander L, Svanborg C, Wold AE, Hanson LA. Intestinal colonization with Enterobacteriaceae in Pakistani and Swedish hospital-delivered infants. Acta Paediatr Scand 1991;80:602-10.
16. Adlerberth I, Jalil F, Carlsson B, Mellander L, Hanson LA, Larsson P, Khalil K, Wold AE. High turnover rate of Escherichia coli strains in the intestinal flora of infants in Pakistan. Epidemiol Infect 1998;121:587-98.
17. Wold AE. The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora? Allergy 1998;53S46:20-5.
18. Matricardi PM. In: Food hygiene and decline in orofecal infection may underlie epidemic of asthma and rhinitis in developed world. Br Med J 2000;320 (press release) http://bmj.bmjjournals.com/content/vol320/issue7232/press_release.shtml.
19. Strachan DP, Warner J, Pickup J, Schweiger M. Pennington H, Stanwell-Smith R, Jones M. The Hygiene Hypothesis. Ped Allergy Immunol 2003;14:145-6.