A unique fourfold intramolecular hydrogen bonding stabilises the structure of trans-bis(2-amino-5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine- N3)aquatrichlororuthenium(III) monohydrate

European Journal of Inorganic Chemistry

Volumn , Issue 2, 1999, Pages 213-215

  Velders, Aldrik H ^a   Ugozzoli, Franco ^b   Biagini Cingi, Marina ^b   Manotti Lanfredi, Anna M ^b   Haasnoot, Jaap G ^a   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Antitumor agents; Crystal structures; Hydrogen bonds; Nitrogen heterocycles; Ruthenium

Indexed keywords

AROMATIC COMPOUNDS; CRYSTAL ATOMIC STRUCTURE; RUTHENIUM;

AMINO GROUP; ANTI-TUMORS; ANTITUMOUR AGENTS; CRYSTALS STRUCTURES; HYDROGEN ACCEPTOR; HYDROGEN BONDING PROPERTIES; INTRAMOLECULAR HYDROGEN BONDING; NITROGEN ATOM; NITROGEN HETEROCYCLES; X-RAY STRUCTURE;

HYDROGEN BONDS;

ANTINEOPLASTIC AGENT; BIS(2 AMINO 5,7 DIMETHYL[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE N3) AQUATRICHLORORUTHENIUM MONOHYDRATE; HETEROCYCLIC COMPOUND; NITROGEN DERIVATIVE; PYRIMIDINE DERIVATIVE; RUTHENIUM COMPLEX; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CHEMICAL STRUCTURE; DRUG STABILITY; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR INTERACTION; X RAY CRYSTALLOGRAPHY;

EID: 0032765590     PISSN: 14341948     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0682(19990202)1999:2<213::AID-EJIC213>3.0.CO;2-2     Document Type: Article

References (20)

1. [1a] B. K. Keppler, M. Henn, U. M. Juhl, M. R. Berger, R. Niebl, F. E. Wagner, Prog. Clin. Biochem. Med. 1989, 10, 41-69.
2. [1b] H. Depenbrock, S. Schmelcher, R. Peter, B. K. Keppler, G. Weirich, T. Block, J. Rastetter, A.-R. Hanauske, Eur. J. Cancer 1997, 33, 2404-2410.
3. J. Reedijk, Chem. Commun. 1996, 801-806.
4. [3a] C. Anderson, A. L. Beauchamp, Can. J. Chem. 1995, 73, 471-482.
5. [3b] O. M. Ni Dhubhghaill, W. R. Hagen, B. K. Keppler, K.-G. Lipponer, P. J. Sadler, J. Chem. Soc., Dalton Trans. 1994, 3305-3310.
6. M. Hartmann, T. J. Einhauser, B. K. Keppler, Chem. Commun. 1996, 1741-1742.
7. K.-G. Lipponer, E. Vogel, B. K. Keppler, Metal-Based Drugs 1996, 3, 243-260.
8. M. Hartmann, K.-G. Lipponer, B. K. Keppler, Inorg. Chim. Acta 1998, 267, 137-141.
9. A. H. Velders, L. Pazderski, F. Ugozzoli, M. Biagini-Cingi, A. M. Manotti-Lanfredi, J. G. Haasnoot, J. Reedijk, Inorg. Chim. Acta 1998, 273, 259-265.
10. [8a] J. M. Salas, M. A. Romero, A. Rahmani, R. Faure, G. Alvarez de Cienfuegos, E. R. T. Tiekink, J. Inorg. Biochem. 1996, 64, 259-271.
11. [8b] J. A. R. Navarro, J. M. Salas, M. A. Romero, R. Vilaplana, F. Gonzalez-Vilchez, R. Faure, J. Med. Chem. 1998, 41, 332-338.
12. [9a] J. G. Haasnoot, T. L. F. Favre, W. Hinrichs, J. Reedijk, Angew. Chem. 1988, 100, 884-886; Angew. Chem. Int. Ed. Engl. 1988, 27, 856-858.
13. [9a] J. G. Haasnoot, T. L. F. Favre, W. Hinrichs, J. Reedijk, Angew. Chem. 1988, 100, 884-886; Angew. Chem. Int. Ed. Engl. 1988, 27, 856-858.
14. [9b] M. Biagini-Cingi, A. M. Manotti-Lanfredi, A Tiripicchio, J. G. Haasnoot, J. Reedijk, Inorg. Chim. Acta 1985, 101, 49-61.
15. [9c] T. L. F. Favre, J. G. Haasnoot, J. Reedijk, Polyhedron 1986, 5, 1405-1411.
16. A. Kreutzberger, Chem. Ber. 1966, 99, 2237-2245.
17. [11a] J. Ochocki, B. Zurowska, J. Mrozinski, H. Kooijman, A. L. Spek, J. Reedijk, Eur. J. Inorg. Chem. 1998, 169-175.
18. [11b] A search was done in the Cambridge Structural Database for transition-metal (Tr) complexes with (double) intramolecular hydrogen bonds of the type Tr-Cl⋯H-N and Tr-OH2⋯N. with H - N and N being part of a ligand coordinated to the metal.
19. A. H. Velders, in preparation.
20. G.-M. Sheldrick, University of Göttingen, Germany, 1996