Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates

Journal of Pharmacy and Pharmacology

Volumn 56, Issue 2, 2004, Pages 197-203

  Sharif, Naj A ^a   Xu, S X ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL 2 (8 CHLORO 10,11 DIHYDRODIBENZ[B,F][1,4]OXAZEPINE 10 CARBONYL)HYDRAZINE; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; 7 [5 (4 BIPHENYLYLMETHOXY) 2 MORPHOLINO 3 OXOCYCLOPENTYL] 4 HEPTENOIC ACID; 9BETA CHLORO 15 CYCLOHEXYL 9 DEOXY 16,17,18,19,20 PENTANOR 3 OXAPROSTAGLANDIN F2 ALPHA; 9BETA CHLORO 15 CYCLOHEXYL 9 DEOXY 16,17,18,19,20 PENTANORPROSTAGLANDIN F2 ALPHA; CARBACYCLIN; CLOPROSTENOL; ENPROSTIL; FLUPROSTENOL; GR 63799X; ILOPROST; MISOPROSTOL; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTANOID; PROSTANOID RECEPTOR; RS 93520; SULPROSTONE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CATTLE; CONTROLLED STUDY; CORPUS LUTEUM; CORRELATION ANALYSIS; DATA ANALYSIS; DISSOCIATION CONSTANT; DRUG BINDING SITE; FEMALE; HAMSTER; ISOTOPE LABELING; MAMMAL; NONHUMAN; RECEPTOR DENSITY; SCATCHARD PLOT; TISSUE HOMOGENATE; UTERUS;

ANIMALS; BINDING SITES; BIPHENYL COMPOUNDS; CATTLE; CLOPROSTENOL; CRICETINAE; DINOPROST; DINOPROSTONE; ENPROSTIL; EPOPROSTENOL; FEMALE; HYDANTOINS; HYDRAZINES; ILOPROST; MISOPROSTOL; PROSTAGLANDINS; PROSTAGLANDINS E, SYNTHETIC; PROSTAGLANDINS F, SYNTHETIC; RECEPTORS, PROSTAGLANDIN E; TRITIUM; UTERUS;

EID: 1242331446     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357022557     Document Type: Article

References (29)

1. Abramovitz, M., Adam, M., Boie, Y., Carriere, M.-C., Denis, D., Godbout, C., Lamotagne, S., Rochette, C., Sawyer, N., Tremblay, N. M., Belley, M., Gallant, M., Dufresne, C., Gareau, Y., Ruel, R., Juteau, H., Labelle, M., Ouimet, N., Metters, K. M. (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogues. Biochim. Biophys. Acta 1483: 285-293
2. 2 receptor subtypes. Eur. J. Pharmacol. 340: 227-241
3. Bowen, W. P., Jerman, J. (1995) Nonlinear regression using spreadsheets. Trends Pharmacol. Sci. 16: 413-417
4. 50) of an enzymatic reaction. Biochem. Pharmacol. 22: 3099-3108
5. Coleman, R. A., Smith, W. L., Narumiya, S. (1994) VIII International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46: 205-229
6. Crankshaw, D. J., Crankshaw, J., Branda, L. A., Daniel, E. E. (1979) Receptors for E type prostaglandins in the plasma membrane of non-pregnant human myometrium. Arch. Biochem. Biophys. 198: 70-77
7. 4 prostanoid receptor. Br. J. Pharmacol. 130: 1919-1926
8. Fernandes, B., Crankshaw, D. (1995) Functional characterizanon of the DP receptor in human myometrium. Eur. J. Pharmacol. 283: 73-81
9. Giles, H., Leff, P., Bolof, M. L., Kelly, M. G., Robertson, A. D. (1989) The classification of prostaglandin DP-receptors in platelets and vasculature using BWA868C, a novel, selective and potent competitive antagonist. Br. J. Pharmacol. 96: 291-300
10. Hellberg, M. R., Sallee, V., McLaughlin, M., Sharif, N. A., DeSantis, L., Dean, T. R, Zinke, P. W. (2001) Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J. Ocular Pharmacol. Ther. 17: 421-432
11. Hellberg, M. R., McLaughlin, M. A., Sharif, N. A., DeSantis, L., Dean, T. R., Kyba, E. P., Bishop, J. E., Klimko, P. G., Zinke, P. W., Selliah, R. D., Barnes, G., DeFaller, J., Kothe, A., Landry, T. L., Sullivan, E. K., Andrew, R., Davis, A. A., Silver, L., Bergamni, M. V. W., Robertson, S., Weiner, A. L., Sallee, V. L. (2002) Identification and characterization of the ocular hypetensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist. Surv. Ophthalmol. (Suppl. 1) 47: S13-S33
12. Hodam, J. R., Snabes, M. C., Kuehl, T. J., Jones. M. A.. Harper, M. J. K. (1999) Characterization of prostaglandin E2 binding to uterine membranes from baboon, rabbit and tree shrew (Tupaia belangeri). J. Mol. Endocrinol. 3: 33-42
13. Kiriyama, M., Ubikubi, F., Kobatashi, T., Hirata, M., Sugimoto, Y., Narumiya, S. (1997) Ligand binding specificities of the eight types and subtypes of mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 122: 217-224
14. 3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. Mol. Pharmacol. 48: 869-879
15. 2 on the contractility of the non pregnant human uterus in vivo. Prostaglandins 10: 255-265
16. McPherson, G. A. (1983) A practical computer based approach to the analysis of radioligand binding experiments. Computer Prog. Biomed. 17: 107-114
17. Munson, P. J., Rodbard, D. (1980) Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107: 220-239
18. Narumiya, S. (1994) Prostanoid receptors: Structure, function, and distribution. In: Goetzl, E. J., Lewis, R. A., Rola-Pleszczynski, M. (eds) Cellular generation, transport, and effects of eicosanoids: biological roley and pharmacological intervention. New York Academy of Sciences, New York, pp 126-138
19. 3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding. Biochim. Biophys. Acta 1175: 343-350
20. Senior, J., Marshall, K., Sangha, R., Clayton, J. K. (1993) In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br. J. Pharmacol. 108: 501-506
21. 1, prostanoid receptor pharmacology characterized using radioligand binding techniques. J. Pharm. Pharmacol. 54: 539-547
22. 3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data. J. Pharmacol. Exp. Ther. 286: 1094-1102
23. 3H]9-β-[+]fluprostenol): carboxylic acid of travoprost (AL-6221), a novel FP-prostaglandin to study the pharmacology and autoradiographic location of the FP receptor. J. Pharm. Pharmacol. 51: 685-694
24. 2α analogue. Adv. Prostaglandin Thrombox. Leukotr. Res. 23: 513-518
25. 2α receptor in bovine preovulatory follicles. Endocrinology 137: 3348-3355
26. Ushikubi, F., Hirata, M., Narumiya, S. (1995) Molecular biology of prostanoid receptors: an overview. J. Lipid Med. Cell Signal. 12: 343-359
27. Wakeling, A. E., Wyngarden, L. J. (1974) Prostaglandin receptors in the human, monkey and hamster uterus. Endocrinology 95: 55-64
28. Woodward, D. F., Krauss, A. H.-P., Chen, J., Liang, Y., Li, C., Protzman, C. E., Bogradus, A., Chen, R., Kedzie, K. M., Krauss, H. A., Gil, D. W., Kharlamb, A., Wheeler, L. A., Babusis, D., Welty, D., Tang-Liu, D. D.-S., Cherkury, M., Andrews, S. W., Burk, R. M., Garst, M. E. (2003) Pharmacological characterization of a novel antiglaucoma agent, bimatoprost (AGN 192024). J. Pharmacol. J. Phrmacol. Exp. Ther. 305: 772-785
29. 2, sulprostone and AH13205 on hamster uterus in vitro. Br. J. Pharmacol. 105: 241