Epstein-Barr virus (EBV) LMP2A alters normal transcriptional regulation following B-cell receptor activation

Virology

Volumn 318, Issue 2, 2004, Pages 524-533

  Portis, Toni ^a   Longnecker, Richard ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

B cells; B cell receptor; Epstein Barr virus; Latency; LMP2A; Microarray

Indexed keywords

B LYMPHOCYTE RECEPTOR; DNA; LATENT MEMBRANE PROTEIN 2A; MEMBRANE PROTEIN; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA METABOLISM; DOWN REGULATION; EPSTEIN BARR VIRUS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA METABOLISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

HUMAN HERPESVIRUS 4; MUS MUSCULUS;

EID: 1242328731     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2003.09.017     Document Type: Article

References (20)

1. Burkhardt A.L., Bolen J.B., Kieff E., Longnecker R. An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases. J. Virol. 66(8):1992;5161-5167.
2. Caldwell R.G., Wilson J.B., Anderson S.J., Longnecker R. Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity. 9:1998;405-411.
3. Caldwell R.G., Brown R.C., Longnecker R. Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EuLMP2A transgenic mice. J. Virol. 74:2000;1101-1113.
4. Chen F., Zou J.Z., di Renzo L. A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1. J. Virol. 69:1995;3752-3758.
5. Chen H., Smith P., Ambinder R.F., Hayward S.D. Expression of Epstein-Barr virus BamHI-A rightward transcripts in latently infected B cells from peripheral blood. Blood. 93:1999;3026-3032.
6. Dykstra M.L., Longnecker R., Pierce S.K. Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR. Immunity. 14(1):2001;57-67.
7. Engels N., Merchant M., Pappu R., Chan A.C., Longnecker R., Wienands J. Epstein-barr virus latent membrane protein 2a (LMP2A) employs the SLP-65 signaling module. J. Exp. Med. 194(3):2001;255-264.
8. Fruehling S., Longnecker R. The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction. Virology. 235:1997;241-251.
9. Fruehling S., Swart R., Dolwick K.M., Kremmer E., Longnecker R. Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency. J. Virol. 72:1998;7796-7806.
10. Kieff E., Rickinson A. Epstein-Barr virus and its replication. Knipe D., Howley P. Fields Virology. Fourth ed. 2001;2511-2573 Lippincott, Williams and Wilkins, Philadelphia, PA.
11. Longnecker R. Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence? Adv. Cancer Res. 79:2000;175-200.
12. Merchant M., Longnecker R. LMP2A survival and developmental signals are transmitted through Btk-dependent and Btk-independent pathways. Virology. 291:2001;46-54.
13. Merchant M., Caldwell R.G., Longnecker R. The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo. J. Virol. 74(19):2000;9115-9124.
14. Miller C.L., Longnecker R., Kieff E. Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes. J. Virol. 67:1993;3087-3094.
15. Miller C.L., Lee J.H., Kieff E., Longnecker R. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc. Natl. Acad. Sci. U.S.A. 91(2):1994;772-776.
16. Miller C.L., Burkhardt A.L., Lee J.H., Stealey B., Longnecker R., Bolen J.B., Kieff E. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity. 2:1995;155-166.
17. Portis T., Longnecker R. Epstein-Barr virus (EBV) LMP2A interferes with global transcription factor regulation when expressed during B lymphocyte development. J. Virol. 77:2003;105-114.
18. Qu L., Rowe D. Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes. J. Virol. 66(6):1992;3715-3724.
19. Thorley-Lawson D.A. Epstein-Barr virus: exploiting the immune system. Nat. Rev. Immunol. 1:2001;75-82.
20. Tierney R.J., Steven N., Young L.S., Rickinson A.B. Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state. J. Virol. 68:1994;7374-7385.