Inflammatory Cytokine Concentrations Are Elevated in Seminal Plasma of Men with Spinal Cord Injuries

Journal of Andrology

Volumn 25, Issue 2, 2004, Pages 250-254

  Basu, Sarmistha ^a   Aballa, Teodoro C ^a   Ferrell, Sean M ^a   Lynne, Charles M ^a   Brackett, Nancy L ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Infertility; Semen; Sperm; T cells; Th1; Th2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOREACTIVITY; IN VITRO STUDY; INFLAMMATION; MALE; MALE INFERTILITY; PRIORITY JOURNAL; SEMEN ANALYSIS; SEMINAL PLASMA; SPERM; SPERMATOZOON MOTILITY; SPINAL CORD INJURY; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 1242320222     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1939-4640.2004.tb02785.x     Document Type: Article

References (39)

1. Abbas AK, Lichtman AH, Pober JS, eds. Cellular and Molecular Immunology. Philadelphia: WB Saunders; 2000.
2. Anderson DJ, Hill JA. Cell-mediated immunity in infertility. Am J Rep Immunol. 1988;17:22-30.
3. Basu S, Lynne CM, Ruiz P, Aballa TC, Ferrell SM, Brackett NL. Cytofluorographic identification of activated T-cell populations in the semen of men with spinal cord injuries. J Androl. 2002;23:551-556.
4. Brackett NL. Semen retrieval by penile vibratory stimulation in men with spinal cord injury. Hum Reprod Update. 1999;5:216-222.
5. Brackett NL, Davi RC, Padron OF, Lynne CM. Seminal plasma of spinal cord injured men inhibits sperm motility of normal men. J Urol. 1996a;155:1632-1635.
6. Brackett NL, Ferrell SM, Aballa TC, et al. An analysis of 653 trials of penile vibratory stimulation on men with spinal cord injury. J Urol. 1998;159:1931-1934.
7. Brackett NL, Lynne CM. The method of assisted ejaculation affects the outcome of semen quality studies in men with spinal cord injury: a review. Neurorehab. 2000;15:89-100.
8. Brackett NL, Lynne CM, Aballa TC, Ferrell SM. Sperm motility from the vas deferens of spinal cord injured men is higher than from the ejaculate. J Urol. 2000;164:712-715.
9. Brackett NL, Nash MS, Lynne CM. Male fertility following spinal cord injury: facts and fiction. Phys Ther. 1996b;76:1221-1231.
10. Buch JP, Kolon TF, Maulik N, Kreutzer DL, Das DK. Cytokines stimulate lipid membrane peroxidation of human sperm. Fertil Steril. 1994;62:186-188.
11. de Lamirande E, Gagnon C. A positive role for the superoxide anion in triggering hyperactivation and capacitation of human spermatozoa. Int J Androl. 1993;16:21-25.
12. Dousset B, Hussenet F, Daudin M, Bujan L, Foliguet B, Nabet P. Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility. Hum Reprod. 1997;12:1476-1479.
13. Estrada LS, Champion HC, Wang R, et al. Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. Int J Androl. 1997;20:237-242.
14. Gruschwitz MS, Brezinschek R, Brezinschek HP. Cytokine levels in the seminal plasma of infertile males. J Androl. 1996;17:158-163.
15. Haney AF, Hughes SF, Weinberg JB. The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro. J Androl. 1992;13:249-253.
16. Hill JA, Haimovici F, Politch JA, Anderson DJ. Effects of soluble products of activated lymphocytes and macrophages (lymphokines and monokines) on human sperm motion parameters. Fertil Steril. 1987;47:460-465.
17. Huleihel M, Lunenfeld E, Levy A, Potashnik G, Glezerman M. Distinct expression levels of cytokines and soluble cytokine receptors in seminal plasma of fertile and infertile men. Ferti Steril. 1996;66:135-139.
18. Klose KJ, Green BA, Smith RS, Adkins RH, MacDonald AM. University of Miami Neuro-Spinal Index (UMNI): a quantitative method for determining spinal cord function. Paraplegia. 1980;18:331-334.
19. Linsenmeyer TA. Male infertility following spinal cord injury. J Am Paraplegic Soc. 1991;14:116-121.
20. Loras B, Vetele F, El Malki A, Rollet J, Soufir JC, Benahmed M. Seminal transforming growth factor-beta in normal and infertile men. Hum Reprod. 1999;14:1534-1539.
21. Majumder GC, Dey CS, Haldar S, Barua M. Biochemical parameters of initiation and regulation of sperm motility. Arch Androl. 1990:24:287-303.
22. Matalliotakis I, Kiriakou D, Fragouli I, Sifakis S, Eliopoulos G, Koumantakis E. Interleukin-6 in seminal plasma of fertile and infertile men. Arch Androl. 1998a;41:43-50.
23. Matalliotakis I, Sifakis S, Goumemou A, et al. Cytokine levels in seminal plasma. Clin Exp Obst Gyn. 1998b;25:58-60.
24. Mire-Sluis AR, Thorpe R. Laboratory protocols for the quantitation of cytokines by bioassay using cytokine responsive cell lines. J Immunol Meth. 1998;211:199-210.
25. Naz RK: Role of cell mediated immunity in infertility. In: Naz RK, ed. Immunology of Reproduction. Boca Raton, Fla: CRC Press; 1985:61-80.
26. Naz RK, Evans W. Decreased levels of interleukin-12 are not correlated with leukocyte concentration and superoxide dismutase activity in semen of infertile men. Arch Androl. 1998;41:91-96.
27. Naz RK, Kaplan P. Increased levels of interleukin-6 in seminal plasma of infertile men. J Androl. 1994;15:220-227.
28. Ohl DA, Denil J, Fitzgerald-Shelton K, et al. Fertility of spinal cord injured males: effect of genitourinary infection and bladder management on results of electroejaculation. J Am Paraplegic Soc. 1992;15:53-59.
29. Ohl DA, Menge A, Jarow J. Seminal vesicle aspiration in spinal cord injured men: insight into poor semen quality. J Urol. 1999;162:2048-2051.
30. Padron OF, Brackett NL, Sharma RK, Lynne CM, Thomas AJ Jr, Agarwal A. Seminal reactive oxygen species and sperm motility and morphology in men with spinal cord injury. Fertil Steril. 1997;67:1115-1120.
31. Paradisi R, Capelli M, Mandini M, Bellavia E, Flamigni C. Increased levels of interferon-gamma in seminal plasma of infertile men. Andrologia. 1996;28:157-161.
32. Rajasekaran M, Hellstrom WJ, Naz RK, Sikka SC. Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril. 1995;64:166-171.
33. Randall JM, Evans DH, Bird VG, Aballa TC, Lynne CM, Brackett NL. Leukocytospermia in spinal cord injured patients is not related to histological inflammatory changes in the prostate. J Urol. 2003;170:897-900.
34. Shimoya K, Matsuzaki N, Tsutsui T, Taniguchi T, Saji F, Tanizawa O. Detection of interleukin-8 (IL-8) in seminal plasma and elevated IL-8 in seminal plasma of infertile patients with leukospermia. Fertil Steril. 1993:59:885-888.
35. Sonksen J, Biering-Sorensen F. Fertility in men with spinal cord or cauda equina lesions. Semin Neurol. 1992;12:106-114.
36. Sonksen J, Ohl DA, Giwercman A, Biering-Sorensen F, Skakkebaek NE, Kristensen JK. Effect of repeated ejaculation on semen quality in spinal cord injured men. J Urol. 1999;161:1163-1165.
37. Trabulsi EJ, Shupp-Byrne D, Sedor J, Hirsh IH. Leukocyte subtypes in electroejaculates of spinal cord injured men. Arch Phys Med Rehabil. 2002;83:31-33.
38. Wincek TJ, Meyer TK, Meyer MR, Kuehl TJ. Absence of a direct effect of recombinant tumor necrosis factor-alpha on human sperm function and murine preimplantation development. [comment]. Fertil Steril. 1991;56:332-339.
39. World Health Organization. Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucous Interaction. Cambridge, United Kingdom: Cambridge University Press; 1999.