Trichloroisocyanuric acid as a novel oxidizing agent for the oxidation of 1,3,5-trisubstituted pyrazolines under both heterogeneous and solvent free conditions

Tetrahedron Letters

Volumn 45, Issue 10, 2004, Pages 2181-2183

  Zolfigol, Mohammad Ali ^a   Azarifar, Davood ^a   Maleki, Behrooz ^a  

^a BU ALI SINA UNIVERSITY   (Iran)

Author keywords

1,3,5 Trisubstituted pyrazolines; Pyrazoles; Solvent free conditions; Trichloroisocyanuric

Indexed keywords

OXIDIZING AGENT; PYRAZOLE; PYRAZOLINE DERIVATIVE; SOLVENT; SYMCLOSENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; EVAPORATION; FILTRATION; OXIDATION; ROOM TEMPERATURE;

EID: 1242295362     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.01.038     Document Type: Article

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30. 1.
31. 4 (10 mL) were stirred vigorously at room temperature. The progress of the reaction was followed by TLC. Reactions were completed after 0.5-1.75 h (Table 2). After the reaction was completed, dry silica gel (1 g) was added to the reaction mixture, the solid materials were removed by filtration and washing with dichloromethane (10 mL). The solvent was evaporated and the pyrazoles 2 were obtained (Table 2). If further purification is needed, flash chromatography on silica gel (eluent: acetone/petroleum ether 1:5) was used to give highly pure 2.
32. 18 simple distillation, and the pyrazoles 2 were obtained (Table 2). If further purification is needed, flash chromatography on silica gel (eluent: acetone/petroleum ether 1:5) was used to give highly pure 2.