Smallpox: Clinical Features, Prevention, and Management

Annals of Pharmacotherapy

Volumn 38, Issue 3, 2004, Pages 440-447

  Guharoy, Roy ^a,g   Panzik, Robert ^b   Noviasky, John A ^c   Krenzelok, Edward P ^d,e   Blair, Donald C ^f  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b Rite Aid   (United States)

^c St Elizabeth Medical Center   (United States)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

^f State University of New York Upstate Medical University: College of Medicine   (United States)

^g University Hospital   (United States)

Author keywords

Bioterrorism; Immunization; Smallpox

Indexed keywords

AGENTS ACTING ON THE EYE; CIDOFOVIR; IMMUNOGLOBULIN; SMALLPOX VACCINE; UNCLASSIFIED DRUG; VACCINIA ANTIBODY;

ABSTRACT REPORT; ACTIVE IMMUNIZATION; ANAPHYLAXIS; ARMY; ASEPTIC MENINGITIS; BACTERIAL INFECTION; BIOLOGICAL WARFARE; CHILL; CLINICAL FEATURE; DIAGNOSTIC APPROACH ROUTE; DRUG HYPERSENSITIVITY; ECZEMA; ECZEMA VACCINATUM; ENCEPHALITIS; EPIDEMIC; ERYTHEMA MULTIFORME; FEVER; HEADACHE; HEALTH CARE PERSONNEL; HOST; HUMAN; HYPOTENSION; IMMUNIZATION; IMMUNOPROPHYLAXIS; INFECTION CONTROL; INFECTION PREVENTION; INJECTION PAIN; INJECTION SITE; KERATITIS; KIDNEY DISEASE; MEDICAL INFORMATION; MEDICAL LITERATURE; MEDLINE; MORTALITY; MYOCARDITIS; NONHUMAN; PATHOGENESIS; PERICARDITIS; POPULATION; POSTVACCINAL ENCEPHALITIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RASH; REVIEW; RISK BENEFIT ANALYSIS; SIDE EFFECT; SMALLPOX; SMALLPOX VIRUS; SUPERINFECTION; TREATMENT CONTRAINDICATION; VACCINATION; VACCINATION REACTION; VACCINIA; VIRUS TRANSMISSION;

ANTIVIRAL AGENTS; BIOTERRORISM; CYTOSINE; FEMALE; HUMANS; INFANT; MALE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; SMALLPOX; SMALLPOX VACCINE;

EID: 1242293858     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1D272     Document Type: Review

References (53)

1. Barquet N, Domingo P. Smallpox: the triumph over the most terrible of the ministers of death. Ann Intern Med 1997;127:635-42.
2. Patterson KB, Runge T. Smallpox and the Native American. Am J Med Sci 2002;323:216-22.
3. Bronze MS, Huycke MM, Machado LJ, Voskuhl G, Greenfield RA. Viral agents as biological weapons and agents of bioterrorism. Am J Med Sci 2002;323:316-25.
4. Breman JG, Henderson DA. Current concepts: diagnosis & management of smallpox. N Engl J Med 2002;346:1300-8.
5. Ropp SL, Jin Q, Knight JC, Massung RF, Esposito JJ. PCR strategy for identification and differentiation of smallpox and other orthopoxviruses. J Clin Microbiol 1995;33:2069-76.
6. Albert MR, Ostheimer KG, Liewehr DJ, Steinberg S, Breman J. Smallpox manifestations and survival during the Boston epidemic of 1901 to 1903. Ann Intern Med 2002;137:993-1000.
7. Varkey P, Poland GA, Cockerill FR, Smith TF, Hagen PT. Confronting bioterrorism: physicians on the front line. Mayo Clin Proc 2002;77:661-72.
8. Radetsky M. Smallpox: a history of its rise and fall. Pediatr Infect Dis 1999;18:85-93.
9. Kaplan EH, Craft DL, Wein LM. Emergency response to a smallpox attack: the case for mass vaccination. Proc Natl Acad Sci 2002;99:10935-40.
10. Esposito JJ, Knight JC. Orthopoxvirus DNA: a comparison of restriction profiles and maps. Virology 1985;143:230-51.
11. Sibley CL. Smallpox vaccination revisited. Am J Nursing 2002;102(9): 26-32.
12. Rao AR. Smallpox. Bombay, India: Kothari Book Depot, 1972.
13. Dixon CW. Smallpox. London: J & A Churchill, 1962.
14. Hope Simpson RE. Infectiousness of communicable diseases in the household (measles, chickenpox, and mumps). Lancet 1952;2:549-54.
15. Centers for Disease Control and Prevention. Interim smallpox response plan and guidelines. www.bt.cdc.gov/DocumentsApp/Smallpox/RPG/ index.asp (accessed 2003 Mar 1).
16. Sepkowitz KA. Current concepts: how contagious is vaccinia? N Engl J Med 2003;348:439-46.
17. Clercq ED. Cidofovir in the treatment of poxvirus infections. Antiviral Res 2002;55:1-13.
18. Bray M, Martinez M, Smee DF, Kefauver D, Thompson E, Huggins JW. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J Infect Dis 2000;181:10-9.
19. Baltimore RS, McMillan JA. Smallpox and the smallpox vaccine controversy. Pediatr Infect Dis 2002;21:789-90.
20. Arita L. Duration of immunity after smallpox vaccination: a study on vaccination policy against smallpox bioterrorism in Japan. Jpn J Infect Dis 2002;55:112:116.
21. Wharton M, Strikas RA, Harpaz R, Rotz L, Schwartz B, Casey CG, et al. Recommendations for using smallpox vaccine in a pre-event vaccination program. MMWR Dispatch 2003;52(Feb 26):1-16.
22. Update: adverse events following civilian smallpox vaccination-United States 2003. MMWR Weekly 2003;52:475-7. www.cdc.gov/mmwr/preview/mmwrhtml/mm5220a5.htm (accessed 2003 Jun 2).
23. Babinchak TJ. Smallpox vaccine. P & T 2003;28:457-9.
24. Redfield RR, Wright DC, James WD, Jones TS, Brown C, Burke DS. Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease. N Engl J Med 1987;316:673-6.
25. Brown EH. Complications of smallpox vaccination. Postgrad Med 1965;41:634-5.
26. Neff JM, Lane M, Pert JH, Moore R, Millar JD, Henderson DA. Complications of smallpox vaccination: national survey in the United States, 1963. N Engl J Med 1967;276:125-32.
27. Nitzkin JL, Anderson L, Skaggs JW, Hernandez C. Complications of smallpox vaccination in Kentucky in 1968: results of a statewide survey. J Kentucky Med Assoc 1971;69:184-90.
28. Lane JM, Ruben FL, Neff JM, Millar JD. Complications of smallpox vaccination, 1968: National Surveillance in the United States. N Engl J Med 1969;281:1201-8.
29. Neff JM, Levine RH, Lane M, Moore R, Millar JD, Henderson DA. Complications of smallpox vaccination in the United States 1963 II: results obtained by four statewide surveys. Pediatrics 1967;39:916-23.
30. Lane JM, Ruben FL, Neff JM, Millar JD. Complications of smallpox vaccination in the United States: national surveillance in the United States. N Engl J Med 1969;281:1201-8.
31. Mellin H, Neff JM, Garber H, Lane JM. Complications of smallpox vaccination: Maryland. Hopkins Med J 1968;126:160-8.
32. Neff JM, Lane JM, Fulginiti VA, Henderson DA. Contact vaccinia-transmission of vaccinia from smallpox vaccination. JAMA 2002;288:1901-5.
33. Update: adverse events following civilian smallpox vaccination-United States 2003. MMWR Weekly August 29, 2003;52:819-20. www.cdc.gov/mmwr/preview/mmwrhtml/mm5234a4.htm (accessed 2003 Oct 4).
34. Grabenstein JD, Winkenweerder W. U.S. military smallpox vaccination program experience. JAMA 2003;289:3278-82.
35. Finlay-Jones LR. Fatal myocarditis after vaccination against small pox: report of a case. N Engl J Med 1964;270:41-3.
36. Lane JM, Ruben FL, Abrutyn E, Millar JD. Deaths attributable to smallpox vaccination, 1959 to 1966, and 1968. JAMA 1970;212:441-4.
37. Ferry BJ. Adverse reactions after smallpox vaccination. Med J Aust 1997;2:180-3.
38. Karjalainen J, Heikkila J, Nieminen MS. Etiology of acute infectious myocarditis. Acta Medica Scand 1983;213:65-73.
39. Helle EJ, Koskenvuo K, Heikkila J, Pikkaranien J, Weckstrom P. Myocardial complications of immunizations. Ann Clin Res 1978;10:280-7.
40. Supplemental recommendations on adverse events following smallpox vaccine in the pre-event vaccination program: recommendations of the Advisory Committee on Immunization Practices. JAMA 2003;289:2064-5.
41. Cardiac deaths after a mass smallpox vaccination campaign - New York City, 1947. MMWR Weekly October 3, 2003;52:933-6. www.cdc.gov/ mmwr/preview/mmwrhtml/mm5239a1.htm (accessed 2003 Oct 6).
42. Grady D. Exclude more from smallpox vaccinations. New York Times, March 29, 2003. www.nytimes.com/2003/03/29international/worldspecial/29SAL.html?ex= 1050117048&ei=1&en+cdec90c387ad0cb0 (accessed 2003 Mar 31).
43. Heart patients not to receive smallpox vaccine for now. ASHP News, March 29, 2003. www.ashp.org/news/showarticle.cfm?id=3357 (accessed 2003 Apr 1).
44. Stillsmoking K. Bioterrorism-are you ready for the silent killer? AORN J 2002;76(3):433-4,437-40,442,444-50.
45. Beeching NJ, Dance DA, Miller AR, Spencer RC. Biological warfare and bioterrorism. BMJ 2002;324:336-9.
46. Henderson DA. The looming threat of bioterrorism. Science 1999;283:1279-82.
47. Nierengarten MD. Positive response to US smallpox vaccine policy. Lancet Infect Dis 2003;3:60.
48. Franz DR, Jahrling PB, Friedlander AM, McClain DJ, Hoover DL, Bryne WR, et al. Clinical recognition and management of patients exposed to biological warfare agents. JAMA 1997;278:399-411.
49. Steinhauer R. Bioterrorism. RN 2002;65(3):48-55.
50. Veenema TG. The smallpox vaccine debate. Am J Nursing 2002;102(9): 33-9.
51. Atlas RM. Bioterrorism. From threat to reality. Ann Rev Microbiol 2002;56:167-85.
52. Lane MJ, Goldstein J. Evaluation of 21st-century risks of smallpox vaccination and policy options. Ann Intern Med 2003;138:488-93.
53. Frey SE, Couch RB, Tacket CO, Treanor JJ, Wolff M, Newman FD, et al. Clinical responses to undiluted and diluted smallpox vaccine. N Engl J Med 2002;346:1265-80.