Exposure to hexanal odor influences maternal behavior and induces neonatal death in Fyn tyrosine kinase-deficient mice

Neuroscience Research

Volumn 48, Issue 3, 2004, Pages 259-267

  Hamaguchi Hamada, Kayoko ^a   Sanbo, Chiaki ^b,c   Hamada, Shun ^a,c   Yagi, Takeshi ^a,b,c  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Aldehyde; Fyn tyrosine kinase; Hexanal; Maternal behavior; Neonatal death; Odor

Indexed keywords

HEXANE; PROTEIN KINASE FYN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AUTOCLAVE; BREEDING; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME DEFICIENCY; FEMALE; HEREDITY; MALE; MATERNAL BEHAVIOR; MOUSE; NEWBORN; NEWBORN DEATH; NONHUMAN; ODOR; OLFACTORY SYSTEM; PHENOTYPE; PRIORITY JOURNAL; PROTEIN KINASE FYN DEFICIENCY; STIMULATION;

EID: 1242293706     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2003.11.003     Document Type: Article

References (26)

1. Akutsu H., Kikusui T., Takeuchi Y., Sano K., Hatanaka A., Mroi Y. Alleviating effects of plant-derived fragrances on stress-induced hypothermia in rats. Physiol. Behav. 75:2002;355-360.
2. Brown J.R., Ye H., Bronson R.T., Dikkes P., Greenberg M.E. A defect in nurturing in mice lacking the immediate early gene fosB. Cell. 86:1996;297-309.
3. Clevenger C.V., Medaglia M.V. The protein tyrosine kinase p59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes. Mol. Endocrinol. 8:1994;674-681.
4. EPA method 5035, 1996. Closed-system purge-and-trap and extraction for volatile organics in soil and waste samples. SW-846, U.S. Environmental Protection Agency, Cincinnati, OH.
5. EPA method 8260b, 1996. Volatile Organic Compounds by Gas Chromatography/Mass Spectrometry (GC/MS). SW-846, U.S. Environmental Protection Agency, Cincinnati, OH.
6. Fleming A.S., Luebke C. Timidity prevents the virgin female rat from being a good mother: emotionality differences between nulliparous and parturient females. Physiol. Behav. 27:1981;863-868.
7. Fleming A. Psychobiology of rat maternal behavior: how and where hormones act to promote maternal behavior at parturition. Ann. N.Y. Acad. Sci. 474:1987;234-251.
8. Gandelman R., Zarrow M.X., Deneberg V.H., Myers M. Olfactory bulb removal eliminates maternal behavior in the mouse. Science. 171:1971;210-211.
9. Grant S.G.N., O'Dell T.J., Karl K.A., Stein P.L., Soriano P., Kandel E.R. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Nature. 258:1992;1903-1910.
10. Hatanaka, A., Kajiwara, T., Matsui, K., 1995. The biogeneration of green odour by green leaves and its physiological functions - past, present and future. Z Naturforsch. 50c, 467-472.
11. Kim S.S., Gallaher D.D., Csallany A.S. Lipophilic aldehydes and related carbonyl compounds in rat and human urine. Lipids. 34:1999;489-496.
12. Kitazawa H., Yagi T., Miyakawa T., Niki H., Kawai N. Abnormal synaptic transmission in the olfactory bulb of fyn-kinase-deficient mice. J. Neurophysiol. 79:1998;137-142.
13. Lefebvre L., Viville S., Barton S.C., Ishino F., Keverne E.B., Surani M.A. Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nat. Genet. 20:1998;163-169.
14. Li L.L., Keverne E.B., Aparicio S.A., Ishino F., Barton S.C., Surani M.A. Regulation of maternal behavior and offspring growth by paternally expressed Peg3. Science. 284:1999;330-333.
15. Lucas B.K., Ormandy C.J., Binart N., Bridges R.S., Kelly P.A. Null mutation of the prolactin receptor gene produces a defect in maternal behavior. Endocrinology. 139:1998;4102-4107.
16. Miyakawa T., Yagi T., Watanabe S., Niki H. Increased fearfulness of Fyn tyrosine kinase deficient mice. Mol. Brain Res. 27:1994;179-182.
17. Miyakawa T., Yagi T., Kagiyama A., Niki H. Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness. Mol. Brain Res. 37:1996;145-150.
18. Ogawa S., Eng V., Taylor J., Lubahn D.B., Korach K.S., Pfaff D.W. Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice. Endocrinology. 139:1998;5070-5081.
19. Ormandy C.J., Camus A., Barra J., Damotte D., Lucas B., Buteau H., Edery M., Brousse N., Babinet C., Binart N., Kelly P.A. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 11:1997;167-178.
20. Rosenblatt, J.S., Mayer, A.D., Siegel, H.I., 1985. Maternal behavior among the nonprimate mammals. In: Adler, N., Pfaff, D., Goy, R.W. (Eds.), Handbook of Behavioral Neurobiology: Reproduction. Plenum Press, New York, pp. 229-298.
21. Single F.N., Rozov A., Burnashev N., Zimmermann F., Hanley D.F., Forrest D., Curran T., Jensen V., Hvalby O., Sprengel R., Seeburg P.H. Dysfunctions in mice by NMDA receptor point mutations NR1 (N598Q) and NR1 (N598R). J. Neurosci. 20:2000;2558-2566.
22. Thomas S.A., Palmiter R.D. Impaired maternal behavior in mice lacking norepinephrine and epinephrine. Cell. 91:1997;583-592.
23. Vandenbergh J.G. Effects of central and peripheral anosmia on reproduction of female mice. Physiol. Behav. 19:1973;257-261.
24. Wehr R., Mansouri A., de Maeyer T., Gruss P. Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body. Development. 124:1997;4447-4456.
25. Yagi T., Aizawa S., Tokunaga T., Shigetani Y., Takeda N., Ikawa Y. A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. Nature. 366:1993;742-745.
26. Yagi T. Molecular mechanisms of Fyn-tyrosine kinase for regulating mammalian behaviors and an ethanol sensitivity. Biochem. Pharmacol. 57:1999;845-850.