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Volumn 40, Issue 3, 2004, Pages 409-416

Tetrathiomolybdate in the treatment of acute hepatitis in an animal model for Wilson disease

Author keywords

Ammonium tetrathiomolybdate; Copper toxicity; Hepatitis; Iron overload; Long Evans Cinnamon rat; Therapy; Wilson disease

Indexed keywords

CHELATING AGENT; COPPER; IRON; METALLOTHIONEIN; POLYMER; TETRATHIOMOLYBDIC ACID;

EID: 1242292347     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2003.11.034     Document Type: Article
Times cited : (21)

References (49)
  • 1
    • 0027452091 scopus 로고
    • The WiIson disease gene is a putative copper transporting P-type ATPase simiIar to the Menkes gene
    • Bull P.C., Thomas G.R., Rommens J.M., Forbes J.R., Cox D.W. The WiIson disease gene is a putative copper transporting P-type ATPase simiIar to the Menkes gene. Nat Genet. 5:1993;327-337.
    • (1993) Nat Genet , vol.5 , pp. 327-337
    • Bull, P.C.1    Thomas, G.R.2    Rommens, J.M.3    Forbes, J.R.4    Cox, D.W.5
  • 2
    • 0027364961 scopus 로고
    • The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene
    • Tanzi R.E., Petrukhin K., Chernow I., Pellequer J.L., Wasco W., Ross B., et al. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet. 5:1993;344-350.
    • (1993) Nat Genet , vol.5 , pp. 344-350
    • Tanzi, R.E.1    Petrukhin, K.2    Chernow, I.3    Pellequer, J.L.4    Wasco, W.5    Ross, B.6
  • 5
    • 0025892297 scopus 로고
    • Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis
    • Li Y., Togashi Y., Sato S., Emoto T., Kang J.H., Takeichi N., et al. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. J Clin Invest. 87:1991;1858-1861.
    • (1991) J Clin Invest , vol.87 , pp. 1858-1861
    • Li, Y.1    Togashi, Y.2    Sato, S.3    Emoto, T.4    Kang, J.H.5    Takeichi, N.6
  • 6
    • 0027977547 scopus 로고
    • Pleiotropic effect of LEC mutation: A rodent model of Wilson's disease
    • Schilsky M.L., Stockert R.J., Sternlieb I. Pleiotropic effect of LEC mutation: a rodent model of Wilson's disease. Am J Physiol. 266:1994;G907-G913.
    • (1994) Am J Physiol , vol.266
    • Schilsky, M.L.1    Stockert, R.J.2    Sternlieb, I.3
  • 7
    • 0028272861 scopus 로고
    • Impaired hepatic copper homeostasis in Long-Evans Cinnamon rats: Reduced biliary excretion of copper
    • Suzuki M., Aoki T. Impaired hepatic copper homeostasis in Long-Evans Cinnamon rats: reduced biliary excretion of copper. Pediatr Res. 35:1994;598-601.
    • (1994) Pediatr Res , vol.35 , pp. 598-601
    • Suzuki, M.1    Aoki, T.2
  • 8
    • 0027516426 scopus 로고
    • Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans Cinnamon mutant rats
    • Yamada T., Agui T., Suzuki Y., Sato M., Matsumoto K. Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans Cinnamon mutant rats. J Biol Chem. 268:1993;8965-8971.
    • (1993) J Biol Chem , vol.268 , pp. 8965-8971
    • Yamada, T.1    Agui, T.2    Suzuki, Y.3    Sato, M.4    Matsumoto, K.5
  • 9
    • 0028001088 scopus 로고
    • The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene
    • Wu J., Forbes J.R., Chen H.S., Cox D.W. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat Genet. 7:1994;541-545.
    • (1994) Nat Genet , vol.7 , pp. 541-545
    • Wu, J.1    Forbes, J.R.2    Chen, H.S.3    Cox, D.W.4
  • 10
    • 0028356598 scopus 로고
    • Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat
    • Yamaguchi Y., Heiny M.E., Shimizu N., Aoki T., Gitlin J.D. Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat. Biochem J. 301:1994;1-4.
    • (1994) Biochem J , vol.301 , pp. 1-4
    • Yamaguchi, Y.1    Heiny, M.E.2    Shimizu, N.3    Aoki, T.4    Gitlin, J.D.5
  • 11
    • 0028290872 scopus 로고
    • The LEC rat: A model for human hepatitis, liver cancer, and much more
    • Mori M., Hattori A., Sawaki M., Tsuzuki N., Sawada N., Oyamada M., et al. The LEC rat: a model for human hepatitis, liver cancer, and much more. Am J Pathol. 144:1994;200-204.
    • (1994) Am J Pathol , vol.144 , pp. 200-204
    • Mori, M.1    Hattori, A.2    Sawaki, M.3    Tsuzuki, N.4    Sawada, N.5    Oyamada, M.6
  • 13
    • 0029810054 scopus 로고    scopus 로고
    • Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans cinnamon rats
    • Kato J., Kobune M., Kohgo Y., Sugawara N., Hisai H., Nakamura T., et al. Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans cinnamon rats. J Clin Invest. 98:1996;923-929.
    • (1996) J Clin Invest , vol.98 , pp. 923-929
    • Kato, J.1    Kobune, M.2    Kohgo, Y.3    Sugawara, N.4    Hisai, H.5    Nakamura, T.6
  • 14
  • 15
    • 0034879787 scopus 로고    scopus 로고
    • Ultrastructural identification of iron and copper accumulation in the liver of a male patient with Wilson disease
    • Shiono Y., Hayashi H., Wakusawa S., Yano M. Ultrastructural identification of iron and copper accumulation in the liver of a male patient with Wilson disease. Med Electron Microsc. 34:2001;54-60.
    • (2001) Med Electron Microsc , vol.34 , pp. 54-60
    • Shiono, Y.1    Hayashi, H.2    Wakusawa, S.3    Yano, M.4
  • 17
    • 0033950320 scopus 로고    scopus 로고
    • Raulin Award Lecture: Wilson's disease therapy with zinc and tetrathiomolybdate
    • Brewer G.J. Raulin Award Lecture: Wilson's disease therapy with zinc and tetrathiomolybdate. J Trace Elem Exp Med. 13:2000;51-61.
    • (2000) J Trace Elem Exp Med , vol.13 , pp. 51-61
    • Brewer, G.J.1
  • 19
    • 0037566015 scopus 로고    scopus 로고
    • A practice guideline on Wilson disease
    • Roberts E.A., Schilsky M.L. A practice guideline on Wilson disease. Hepatology. 37:2003;1475-1492.
    • (2003) Hepatology , vol.37 , pp. 1475-1492
    • Roberts, E.A.1    Schilsky, M.L.2
  • 20
    • 0023178114 scopus 로고
    • Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy
    • Brewer G.J., Terry C.A., Aisen A.M., Hill G.M. Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy. Arch Neurol. 44:1987;490-494.
    • (1987) Arch Neurol , vol.44 , pp. 490-494
    • Brewer, G.J.1    Terry, C.A.2    Aisen, A.M.3    Hill, G.M.4
  • 22
    • 0028243178 scopus 로고
    • Treatment of Wilson's disease with ammonium tetrathiomolybdate. I. Initial therapy in 17 neurologically affected patients
    • Brewer G.J., Dick R.D., Johnson V., Wang Y., Yuzbasiyan-Gurkan V., Kluin K., et al. Treatment of Wilson's disease with ammonium tetrathiomolybdate. I. Initial therapy in 17 neurologically affected patients. Arch Neurol. 51:1994;545-554.
    • (1994) Arch Neurol , vol.51 , pp. 545-554
    • Brewer, G.J.1    Dick, R.D.2    Johnson, V.3    Wang, Y.4    Yuzbasiyan-Gurkan, V.5    Kluin, K.6
  • 23
    • 0029821201 scopus 로고    scopus 로고
    • Treatment of Wilson disease with ammonium tetrathiomolybdate. II. Initial therapy in 33 neurologically affected patients and follow-up with zinc therapy
    • Brewer G.J., Johnson V., Dick R.D., Kluin K.J., Fink J.K., Brunberg J.A. Treatment of Wilson disease with ammonium tetrathiomolybdate. II. Initial therapy in 33 neurologically affected patients and follow-up with zinc therapy. Arch Neurol. 53:1996;1017-1025.
    • (1996) Arch Neurol , vol.53 , pp. 1017-1025
    • Brewer, G.J.1    Johnson, V.2    Dick, R.D.3    Kluin, K.J.4    Fink, J.K.5    Brunberg, J.A.6
  • 24
    • 0031956122 scopus 로고    scopus 로고
    • Association of copper to metallothionein in hepatic lysosomes of Long-Evans Cinnamon (LEC) rats during the development of hepatitis
    • Klein D., Lichtmannegger J., Heinzmann U., Müller-Höcker J., Michaelsen S., Summer K.H. Association of copper to metallothionein in hepatic lysosomes of Long-Evans Cinnamon (LEC) rats during the development of hepatitis. Eur J Clin Invest. 28:1998;302-310.
    • (1998) Eur J Clin Invest , vol.28 , pp. 302-310
    • Klein, D.1    Lichtmannegger, J.2    Heinzmann, U.3    Müller-Höcker, J.4    Michaelsen, S.5    Summer, K.H.6
  • 25
    • 0033953627 scopus 로고    scopus 로고
    • Dissolution of copper-rich granules in hepatic lysosomes by D-penicillamine prevents the development of fulminant hepatitis in Long-Evans Cinnamon rats
    • Klein D., Lichtmannegger J., Heinzmann U., Summer K.H. Dissolution of copper-rich granules in hepatic lysosomes by D-penicillamine prevents the development of fulminant hepatitis in Long-Evans Cinnamon rats. J Hepatol. 32:2000;193-201.
    • (2000) J Hepatol , vol.32 , pp. 193-201
    • Klein, D.1    Lichtmannegger, J.2    Heinzmann, U.3    Summer, K.H.4
  • 26
    • 0028821629 scopus 로고
    • Copper binding to rabbit liver metallothionein. Formation of a continuum of copper(I)-thiolate stoichiometric species
    • Presta A., Green A.R., Zelazowski A., Stillman M.J. Copper binding to rabbit liver metallothionein. Formation of a continuum of copper(I)-thiolate stoichiometric species. Eur J Biochem. 227:1995;226-240.
    • (1995) Eur J Biochem , vol.227 , pp. 226-240
    • Presta, A.1    Green, A.R.2    Zelazowski, A.3    Stillman, M.J.4
  • 27
    • 0025183445 scopus 로고
    • Quantitation of Cu-containing metallothionein by a Cd-saturation method
    • Klein D., Bartsch R., Summer K.H. Quantitation of Cu-containing metallothionein by a Cd-saturation method. Anal Biochem. 189:1990;35-39.
    • (1990) Anal Biochem , vol.189 , pp. 35-39
    • Klein, D.1    Bartsch, R.2    Summer, K.H.3
  • 28
    • 0027516426 scopus 로고
    • Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans Cinnamon mutant rat
    • Yamada T., Agui T., Suzuki Y., Sato M., Matsumoto K. Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans Cinnamon mutant rat. J Biol Chem. 268:1993;8965-8971.
    • (1993) J Biol Chem , vol.268 , pp. 8965-8971
    • Yamada, T.1    Agui, T.2    Suzuki, Y.3    Sato, M.4    Matsumoto, K.5
  • 30
    • 0028057852 scopus 로고
    • Liver transplantation for Wilson's disease: Indication and outcome
    • Schilsky M.L., Scheinberg I.H., Sternlieb I. Liver transplantation for Wilson's disease: indication and outcome. Hepatology. 19:1994;583-587.
    • (1994) Hepatology , vol.19 , pp. 583-587
    • Schilsky, M.L.1    Scheinberg, I.H.2    Sternlieb, I.3
  • 31
    • 0019817576 scopus 로고
    • An investigation of the effects of intravenous administration of thiomolybdate on copper metabolism in chronic Cu-poisoned sheep
    • Gooneratne S.R., Howell J.M., Gawthorne J.M. An investigation of the effects of intravenous administration of thiomolybdate on copper metabolism in chronic Cu-poisoned sheep. Br J Nutr. 46:1981;469-480.
    • (1981) Br J Nutr , vol.46 , pp. 469-480
    • Gooneratne, S.R.1    Howell, J.M.2    Gawthorne, J.M.3
  • 32
    • 0027373911 scopus 로고
    • Selective removal of copper bound to metallothionein in the liver of LEC rats by tetrathiomolybdate
    • Suzuki K.T., Yamamoto K., Kanno S., Aoki Y., Takeichi N. Selective removal of copper bound to metallothionein in the liver of LEC rats by tetrathiomolybdate. Toxicology. 83:1993;149-158.
    • (1993) Toxicology , vol.83 , pp. 149-158
    • Suzuki, K.T.1    Yamamoto, K.2    Kanno, S.3    Aoki, Y.4    Takeichi, N.5
  • 33
    • 0028862422 scopus 로고
    • Molybdenum and copper kinetics after tetrathiomolybdate injection in LEC rats: Specific role of serum albumin
    • Suzuki K.T., Ogra Y., Ohmichi M. Molybdenum and copper kinetics after tetrathiomolybdate injection in LEC rats: specific role of serum albumin. J Trace Elem Med Biol. 9:1995;170-175.
    • (1995) J Trace Elem Med Biol , vol.9 , pp. 170-175
    • Suzuki, K.T.1    Ogra, Y.2    Ohmichi, M.3
  • 34
    • 0028909650 scopus 로고
    • Interactions of zinc and molybdenum with copper in therapy of Wilson's disease
    • Brewer G.J. Interactions of zinc and molybdenum with copper in therapy of Wilson's disease. Nutrition. 11:1995;114-116.
    • (1995) Nutrition , vol.11 , pp. 114-116
    • Brewer, G.J.1
  • 35
    • 0033974144 scopus 로고    scopus 로고
    • Excretion of copper complexed with thiomolybdate into the bile and blood in LEC rats
    • Komatsu Y., Sadakata I., Ogra Y., Suzuki K.T. Excretion of copper complexed with thiomolybdate into the bile and blood in LEC rats. Chem Biol Interact. 124:2000;217-231.
    • (2000) Chem Biol Interact , vol.124 , pp. 217-231
    • Komatsu, Y.1    Sadakata, I.2    Ogra, Y.3    Suzuki, K.T.4
  • 36
    • 0032965190 scopus 로고    scopus 로고
    • The effect of subcutaneous tetrathiomolybdate administration on copper and iron metabolism, including their regional redistribution in the brain, in the Long-Evans Cinnamon rat, a bona fide animal model for Wilson's disease
    • Sugawara N., Ikeda T., Lai Y.R., Sugawara C. The effect of subcutaneous tetrathiomolybdate administration on copper and iron metabolism, including their regional redistribution in the brain, in the Long-Evans Cinnamon rat, a bona fide animal model for Wilson's disease. Pharmacol Toxicol. 84:1999;211-217.
    • (1999) Pharmacol Toxicol , vol.84 , pp. 211-217
    • Sugawara, N.1    Ikeda, T.2    Lai, Y.R.3    Sugawara, C.4
  • 37
    • 0029014488 scopus 로고
    • Formation of copper-metallothionein/tetrathiomolybdate complex is the first step in removal of Cu from LEC rats
    • Suzuki K.T., Ogra Y. Formation of copper-metallothionein/ tetrathiomolybdate complex is the first step in removal of Cu from LEC rats. Res Commun Mol Pathol Pharmacol. 88:1995;187-195.
    • (1995) Res Commun Mol Pathol Pharmacol , vol.88 , pp. 187-195
    • Suzuki, K.T.1    Ogra, Y.2
  • 39
    • 0030296588 scopus 로고    scopus 로고
    • Production of hydroxyl radicals by copper-containing metallothionein: Roles as prooxidant
    • Suzuki K.T., Rui M., Ueda J., Ozawa T. Production of hydroxyl radicals by copper-containing metallothionein: roles as prooxidant. Toxicol Appl Pharmacol. 141:1996;231-237.
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 231-237
    • Suzuki, K.T.1    Rui, M.2    Ueda, J.3    Ozawa, T.4
  • 40
    • 0035866581 scopus 로고    scopus 로고
    • Cu-metallothioneins (Cu(I)8-MTs) in LEC rat livers 13 weeks after birth still act as antioxidants
    • Shishido N., Nakayama K., Takazawa A., Ohyama T., Nakamura M. Cu-metallothioneins (Cu(I)8-MTs) in LEC rat livers 13 weeks after birth still act as antioxidants. Arch Biochem Biophys. 387:2001;216-222.
    • (2001) Arch Biochem Biophys , vol.387 , pp. 216-222
    • Shishido, N.1    Nakayama, K.2    Takazawa, A.3    Ohyama, T.4    Nakamura, M.5
  • 41
    • 0028411435 scopus 로고
    • Impaired biliary excretion of copper and lysosomal enzymes in Long-Evans Cinnamon
    • Abe S., Yamazaki K., Takikawa S., Suzuki K. Impaired biliary excretion of copper and lysosomal enzymes in Long-Evans Cinnamon. Tohoku J Exp Med. 172:1994;355-367.
    • (1994) Tohoku J Exp Med , vol.172 , pp. 355-367
    • Abe, S.1    Yamazaki, K.2    Takikawa, S.3    Suzuki, K.4
  • 42
    • 0037442613 scopus 로고    scopus 로고
    • Tetrathiomolybdate causes formation of hepatic copper-molybdenum clusters in an animal model of Wilson's disease
    • George G.N., Pickering I.J., Harris H.H., Gailer J., Klein D., Lichtmannegger J., Summer K.H. Tetrathiomolybdate causes formation of hepatic copper-molybdenum clusters in an animal model of Wilson's disease. J Am Chem Soc. 125:2003;1704-1705.
    • (2003) J Am Chem Soc , vol.125 , pp. 1704-1705
    • George, G.N.1    Pickering, I.J.2    Harris, H.H.3    Gailer, J.4    Klein, D.5    Lichtmannegger, J.6    Summer, K.H.7
  • 43
    • 0026180316 scopus 로고
    • Copper metabolism in LEC rats aged 30 and 80 day old: Induction of Cu-metallothionein and status of zinc and iron
    • Sugawara N., Sugawara C., Sato M., Katakura M., Takahashi H., Mori M. Copper metabolism in LEC rats aged 30 and 80 day old: Induction of Cu-metallothionein and status of zinc and iron. Res Commun Chem Pathol Pharmacol. 72:1991;353-362.
    • (1991) Res Commun Chem Pathol Pharmacol , vol.72 , pp. 353-362
    • Sugawara, N.1    Sugawara, C.2    Sato, M.3    Katakura, M.4    Takahashi, H.5    Mori, M.6
  • 44
    • 0029810054 scopus 로고    scopus 로고
    • Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats
    • Kato J., Kobune M., Kohgo Y., Sugawara N., Hisai H., Nakamura T., et al. Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats. J Clin Invest. 98:1996;923-929.
    • (1996) J Clin Invest , vol.98 , pp. 923-929
    • Kato, J.1    Kobune, M.2    Kohgo, Y.3    Sugawara, N.4    Hisai, H.5    Nakamura, T.6
  • 45
    • 0142222530 scopus 로고    scopus 로고
    • The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption
    • Anderson G.J., Frazer D.M., McKie A.T., Vulpe C.D. The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption. Blood Cells Mol Dis. 29:2002;367-375.
    • (2002) Blood Cells Mol Dis , vol.29 , pp. 367-375
    • Anderson, G.J.1    Frazer, D.M.2    McKie, A.T.3    Vulpe, C.D.4
  • 46
    • 0030748640 scopus 로고    scopus 로고
    • Selenium deficiency does not promote acute hepatitis in Long-Evans Cinnamon (LEC) rats
    • Hamada J., Kobayashi N., Kashiwazaki H., Tonoki H., Moriuchi T. Selenium deficiency does not promote acute hepatitis in Long-Evans Cinnamon (LEC) rats. J Trace Elem Exp Med. 10:1997;119-128.
    • (1997) J Trace Elem Exp Med , vol.10 , pp. 119-128
    • Hamada, J.1    Kobayashi, N.2    Kashiwazaki, H.3    Tonoki, H.4    Moriuchi, T.5
  • 47
    • 0035111046 scopus 로고    scopus 로고
    • The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats
    • Yamamoto H., Watanabe T., Mizuno H., Endo K., Fukushige J., Hosokawa T., et al. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 34:2001;69-80.
    • (2001) Free Radic Res , vol.34 , pp. 69-80
    • Yamamoto, H.1    Watanabe, T.2    Mizuno, H.3    Endo, K.4    Fukushige, J.5    Hosokawa, T.6
  • 48
    • 0030061104 scopus 로고    scopus 로고
    • Mechanisms of selective copper removal by tetrathiomolybdate from metallothionein in LEC rats
    • Ogra Y., Ohmichi M., Suzuki K.T. Mechanisms of selective copper removal by tetrathiomolybdate from metallothionein in LEC rats. Toxicology. 106:1996;75-83.
    • (1996) Toxicology , vol.106 , pp. 75-83
    • Ogra, Y.1    Ohmichi, M.2    Suzuki, K.T.3
  • 49
    • 0032771207 scopus 로고    scopus 로고
    • Comparative mechanism and toxicity of tetra- and dithiomolybdates in the removal of copper
    • Ogra Y., Komada Y., Suzuki K.T. Comparative mechanism and toxicity of tetra- and dithiomolybdates in the removal of copper. J Inorg Biochem. 75:1999;199-204.
    • (1999) J Inorg Biochem , vol.75 , pp. 199-204
    • Ogra, Y.1    Komada, Y.2    Suzuki, K.T.3


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