The effect of subcutaneous tetrathiomolybdate administration on copper and iron metabolism, including their regional redistribution in the brain, in the Long-Evans Cinnamon rat, a bona fide animal model for Wilson's disease

Pharmacology and Toxicology

Volumn 84, Issue 5, 1999, Pages 211-217

  Sugawara, Naoki ^a,b   Ikeda, Toshiko ^a   Lai, Yu Rong ^a   Sugawara, Chieko ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; COPPER; FERRITIN; HEMOGLOBIN; IRON; METALLOTHIONEIN; TETRATHIOMOLYBDIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; COPPER METABOLISM; CORPUS STRIATUM; DRUG EFFECT; HIPPOCAMPUS; HYPOTHALAMUS; IRON METABOLISM; LIVER LEVEL; MALE; MEDULLA OBLONGATA; MESENCEPHALON; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TISSUE DISTRIBUTION; WILSON DISEASE;

ANIMALIA; CINNAMOMUM VERUM;

EID: 0032965190     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1999.tb01485.x     Document Type: Article

References (32)

1. Brewer , G. J., R. D. Dick, V. Johnson, Y. Wang, V. Yuzbasiyan-Gurkan, K. Kluin, J. K. Fink & A. Aisen: Treatment of Wilson's disease with ammonium tetrathiomolybdate. Arch. Neurol. 1994, 51, 545-554.
2. Dancis, A., D. S. Yuan, D. Haile, C. Askwith, D. Eide, C. Moehle, J. Kaplan & R. D. Klausner: Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport. Cell 1994, 76, 393-402.
3. Dincer, Z., W. R. Haywood & W. R. Humphries: Copper associated toxic encephalopathy in copper-poisoned sheep treated with tetrathiomolybdate (TTM). In Procedings of the Eight International Symposium on Trace Elements in Man and Animal. Eds.: M. Anke, D. Meissner & C. F. Mills. Verlag Media Touristik, Gersdorf, 1993, pp. 982-984.
4. Fell, B. F., D. Dinsdale & T. T. El-Gallad: Gut pathology of rats dosed with tetrathiomolybdate. J. Comp. Pathol. 1979, 89, 495-514.
5. Glowinski, J. & L. L. Iversen: Regional studies of catecholamines in the rat brain. J. Neurochem. 1966, 13, 655-669.
6. Hafkemeyer, P., M. Schupp, M. Storch, W. Gerok & D. Haussinger: Excessive iron storage in a patient with Wilson's disease. Clin. Invest. 1994, 72, 134-136.
7. Johnson, H. A., S. Osaki & E. Frieden: A micromethod for the determination of ferroxidase (ceruloplasmin) in human serum. Clin. Chem. 1967, 13, 142-150.
8. Kato, J., Y. Kohgo, N. Sugawara, S. Katsuki, N. Sintani, K. Fujikawa, E. Miyazaki, M. Kobune, N. Takeichi & Y. Niitsu: Abnormal hepatic iron accumulation in LEC rats. Jap. J. Cancer Res. 1993, 84, 219-222.
9. Lai, Y.-R. & N. Sugawara: Outputs of hepatic copper and cadmium stimulated by tetrathiomolybdate (TTM) injection in Long-Evans Cinnamon (LEC) rats pretreated with cadmium, and in Fischer rats pretreated with copper and cadmium. Toxicology 1997, 120, 47-54.
10. Li, Y., Y. Togashi, S. Sato, T. Emoto, J.-H. Kang, N. Takeichi, H. Kobayashi, Y. Kojima, Y. Une & J. Uchino: Spontaneous hepatitis copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease. J. Clin. Invest. 1991, 87, 1858-1861.
11. 35S]-lableled metallothionein in vitro; implications for Wilson's disease therapy. J. Inorg. Biochem. 1990, 41, 87-92.
12. Nakajima, K., K. Suzuki, N. Otaki & M. Kimura: Epitope mapping of metallothionein antibodies. Meth. Enzymol. 1991, 205, 174-189.
13. Ono, T., S. Takeda & M. C. Yoshida: The WD gene for Wilson's disease links to the hepatitis of LEC rats. Jap. J. Cancer Res. 1994, 85, 771-774.
14. Osaki, S., D. A. Johnson & E. Frieden: The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J. Biol. Chem. 1966, 241, 2746-2751.
15. Oshiro S., H. Nakajima, T. Markello, D. Krasnewich, I. Bernardini & W. A. Gahl: Redox, transferrin-independent, and receptor-mediated endocytosis iron uptake systems in cultured human fibroblasts. J. Biol. Chem. 1993, 268, 21566-21591.
16. Owen, Jr. C. A.: Effects of iron on copper metabolism and copper on iron metabolism in rats. Amer. J. Physiol. 1973, 224, 514-518.
17. Ravin, H. A.: An improved colorimetric enzymatic assay of ceruloplasmin. J. Lab. Clin. Med. 1961, 58, 161-168.
18. Read, R., J. Sutherland & P. Ghosh: The matrix components of the epiphyseal growth plate and articular cartilages from dogs treated with ammonium tetrathiomolybdate, a copper antagonist. Aust. J. Exp. Med. Sci. 1986, 64, 545-562.
19. Roberts, E. A.: Drug therapy for liver disease. In: Pediatric gastrointestinal disease. 2nd ed. Eds.: W. A. Walker, P. R. Durie, J. R. Hamilton, J. A. Walker-Smith & J. B. Walkins. Mosby, St. Louis, 1996, pp. 1994-2010.
20. Sternlieb, I. & I. H. Scheinberg: Wilson's disease. In: Diseases of the liver. Eds.: L. Schiff & E. R. Schiff. J. B. Lippincott Co., Philadelphia, 1993, pp. 659-668.
21. Sugawara, N.: Influence of cadmium on zinc distribution in the mouse liver and kidney: role of metallothionein. Toxicol. Appl. Pharmacol. 1977, 42, 377-386.
22. Sugawara, N., C. Sugawara, M. Katakura, H. Takahashi & M. Mori: Copper metabolism in the LEC rat: Involvement of induction of metallothionein and disposition of zinc and iron. Experientia 1991, 47, 1060-1063.
23. Sugawara, N., C. Sugawara, M. Sato, H. Takahashi & M. Mori: Excessive accumulation of hepatic copper in LEC rats aged 80 days without hepatitis and 130 days with hepatitis. Pharmacology & Toxicology 1992, 71, 321-324.
24. Sugawara, N., D.-M. Li & C. Sugawara: Removal of copper from the liver of Long-Evans Cinnamon (LEC) rats by tetrathiomolybdate (TTM) injection: the main excretion route is via blood, not bile. Res. Commun. Mol. Pathol. Pharmacol. 1994, 85, 217-226.
25. Suzuki, K. T., Y. Ogra & M. Ohmichi: Molybdenum and copper kinetics after tetrathiomolybdate injection in LEC rats: specific role of serum albumin. J. Trace Elem. Med. Biol. 1995, 9, 170-175.
26. Terada, K., Y. Kawarada, N. Miura, O. Yasui, K. Koyama & T. Sugiyama: Copper incorporation into ceruloplasmin in rat livers. Biochim. Biophys. Acta 1995, 1270, 58-62.
27. Uchiyama, M. & M. Mihara: Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 1978, 86, 271-278.
28. Walshe, J. M.: The treatment of Wilson's disease with trientin. Lancet 1982, 1, 643-647.
29. 4) as an 'anti-copper' agent in man. In: Orphan disease and orphan drug. Eds.: I. H. Scheinberg & J. M. Walshe University Press, Manchester, 1985, pp.76 85.
30. Williams, D. M., F. S. Kennedy & B. G. Green: Hepatic iron accumulation in copper-deficient rats. Brit. J. Nutr. 1983, 50, 653-660.
31. Wu, J., J. R. Forbes, H. S. Chen & D. W. Cox: The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nature Genet. 1994, 7, 541-545.
32. Yuasa, M., C. Sugawara, Y.-R. Lai & N. Sugawara: Iron metabolism of the Long-Evans Cinnamon (LEC) rat before the onset of hepatitis. Sapporo Med. J. 1996, 65, 451-462 (in Japanese with English summary).