Hypoxia alters GABAA receptor function and subunit expression in NT2-N neurons

Neuropharmacology

Volumn 46, Issue 3, 2004, Pages 318-330

  Gao, Lei ^a   Lyons, Anne R ^a   Greenfield Jr , L John ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Benzodiazepine; Electrophysiology; NTera2; Patch clamp; RT PCR; Zolpidem

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BARBITURIC ACID DERIVATIVE; DIAZEPAM; MESSENGER RNA; RECEPTOR SUBUNIT; ZINC; ZOLPIDEM;

ALPHA CHAIN; BETA CHAIN; CELL HYPOXIA; CELL ULTRASTRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; NERVE CELL; NERVE CELL NECROSIS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; ARTICLE; BIOSYNTHESIS; CELL SURVIVAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; HUMANS; NEURONS; RECEPTORS, GABA-A; RNA, MESSENGER;

EID: 1242284214     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2003.09.008     Document Type: Article

References (39)

1. Aizenman E., Sinor J.D., Brimecombe J.C., Herin G.A. Alterations of N-methyl-D-aspartate receptor properties after chemical ischemia. Journal of Pharmacology and Experimental Therapeutics. 295:2000;572-577.
2. A receptor in gerbil hippocampus following cerebral ischemia. Journal of Neurochemistry. 65:1995;2808-2811.
3. Andrews P.W. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Developmental Biology. 103:1984;285-293.
4. Beczkowska I.W., Gracy K.N., Pickel V.M., Inturrisi C.E. Inducible expression of N-methyl-D-aspartate receptor, and delta and mu opioid receptor messenger RNAs and protein in the NT2-N human cell line. Neuroscience. 79:1997;855-862.
5. Bergamasco B., Penna P., Ferrero P., Gavinelli R. Neonatal hypoxia and epileptic risk: a clinical prospective study. Epilepsia. 25:1984;131-146.
6. Bickler P.E.F., Donohoe P.H.F., Buck L.T. Hypoxia-induced silencing of NMDA receptors in turtle neurons. Journal of Neuroscience. 20:2000;3522-3528.
7. 2+. Journal of Neurochemistry. 55:1990;1690-1696.
8. A receptor function and expression in human NT2-N cells. 2002 Abstract Viewer/Itinerary Planner. Society for Neuroscience, Washington, DC, Program No. 433.2, online.
9. Gentet L.J., Stuart G.J., Clements J.D. Direct measurement of specific membrane capacitance in neurons. Biophys J. 79:2000;314-320.
10. A receptor gating kinetics on the α-subunit isoform: implications for structure-function relations and synaptic transmission. Journal of Physiology. 489:1995;529-543.
11. A receptor currents elicited by a "multipuffer" drug application device. Pflügers Archives. 432:1996;1080-1090.
12. Guerguerian A.M.F., Brambrink A.M.F., Traystman R.J.F., Huganir R.L.F., Martin L.J. Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia. Molecular Brain Research. 104:2002;66-80.
13. Gurd J.W.F., Bissoon N.F., Beesley P.W.F., Nakazawa T.F., Yamamoto T.F., Vannucci S.J. Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7- and 21-day-old rats. Journal of Neurochemistry. 82:2002;848-856.
14. Hagberg H., Andersson P., Kjellmer I., Thiringer K., Thordstein M. Extracellular overflow of glutmate,aspartate,GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia. Neuroscience Letters. 78:1987;311-317.
15. Hallett M. Physiology of human posthypoxic myoclonus. Movement Disorders. 15:2000;8-13.
16. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archives. 391:1981;85-100.
17. A response under experimental ischemia in acutely dissociated CA1 pyramidal neurons of the rat. Journal of Physiology (London). 500:1997;673-688.
18. A receptor activation, deactivation and desensitization. 2002 Abstract Viewer/Itinerary Planner. Society for Neuroscience, Washington, DC, Program No. 40.18, online.
19. Inglefield J.R., Schwartz-Bloom R.D. Optical imaging of hippocampus neurons with a chloride-sensitive dye:early effects of in vitro ischemia. Journal of Neurochemistry. 70:1998;2500-2509.
20. A receptors. Progress in Neurobiology. 67:2002;113-159.
21. A receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil. Hippocampus. 3:1993;527-537.
22. Low J.A., Galbraith R.S., Muir D.W., Killen H.L., Pater E.A., Karchmar E.J. The relationship between perinatal hypoxia and newborn encephalopathy. American Journal of Obstetrics and Gynecology. 152:1985;256-260.
23. A receptor channels. Annual Review of Neuroscience. 17:1994;569-602.
24. Machaalani R., Waters K.A. Distribution and quantification of NMDA R1 mRNA and protein in the piglet brainstem and effects of intermittent hypercapnic hypoxia (IHH). Brain Research. 951:2002;293-300.
25. Mishra O.P., Fritz K.I., Delivoria-Papadopoulos M. NMDA receptor and neonatal hypoxic brain injury. Mental Retardation and Developmental Disabilities Research Reviews. 7:2001;249-253.
26. A receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. Journal of Neuroscience. 18:1998;4993-5007.
27. A receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells. Journal of Neuroscience. 19:1999;7057-7065.
28. 3H]flunitrazepam in the rat brain under hypoxia. Journal of Neurochemistry. 51:1982;1111-1117.
29. Onodera H., Sato G., Kogure K. GABA and benzodiazepam receptors in the gerbil brain after transient ischemia: demonstration by quantitative receptor autoradiography. Journal of Cerebral Blood Flow and Metabolism. 7:1987;82-88.
30. Petito C.K., Feldmann E., Pulsinelli W.A., Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology. 37:1987;1281-1286.
31. Pleasure S.J., Page C., Lee V.M. Pure postmitotic polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. Journal of Neuroscience. 12:1992;1802-1815.
32. Rootwelt T., Dunn M., Yudkoff M., Itoh T., Almaas R., Pleasure D. Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non-NMDA glutamate receptors. Journal of Neurochemistry. 71:1998;1544-1553.
33. A receptor subtypes. Nature. 401:2000;796-800.
34. Schmidt-Kastner R., Freund T.F. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience. 40:1991;599-636.
35. Schwartz R.D., Yu X., Katzman M.R., Hayden-Hixon D.M., Perry J.M. Diazepam, given post-ischemia, protects selectively vulnerable neurons in rat striatum and hippocampus. Journal of Neuroscience. 15:1995;529-539.
36. A neurotransmission and cerebral ischemia. Journal of Neurochemistry. 77:2001;353-371.
37. Van Gelder R., Von Zastrow M., Yool A., Dement W., Barchas J., Eberwine J. Amplified RNA (aRNA) synthesized from limited quantities of heterogeneous cDNA. Proc. Natl. Acad. Sci. USA. 87:1990;1663-1667.
38. Yue X., Mehmet H., Penrice J., Cooper C., Cady E., Wyatt J.S., Reynolds E.O., Edwards A.D., Squier M.V. Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischemia. Neuropathology and Applied Neurobiology. 23:1997;16-25.
39. Zanelli S.A.F., Ashraf Q.M.F., Mishra O.P. Nitration is a mechanism of regulation of the NMDA receptor function during hypoxia. Neuroscience. 112:2002;869-877.