Preparation, characterization, and in vitro evaluation of physostigmine-loaded poly(ortho ester) and poly(ortho ester)/poly(D,L-lactide- co-glycolide) blend microspheres fabricated by spray drying

Biomaterials

Volumn 25, Issue 16, 2004, Pages 3275-3282

  Wang, Ling ^a   Chaw, Cheng Shu ^a   Yang, Yi Yan ^a   Moochhala, Shabbir M ^a   Zhao, Bin ^a   Ng, Steve ^b   Heller, Jorge ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AP Pharma   (United States)

Author keywords

Microspheres; Physostigmine; Poly(DL lactide co glycolide); Poly(ortho ester); Poly(ortho ester) poly(lactide co glycolide) blend

Indexed keywords

DEGRADATION; DRUG PRODUCTS; GLASS TRANSITION; PHASE SEPARATION; POLYESTERS; SCANNING ELECTRON MICROSCOPY;

INCUBATIONS; MICROSPHERES;

BIOMATERIALS;

MICROSPHERE; PHYSOSTIGMINE DERIVATIVE; POLY(ORTHO ESTER); POLYGLACTIN;

ARTICLE; ENCAPSULATION; EVALUATION; GLASS TRANSITION TEMPERATURE; IN VITRO STUDY; PRIORITY JOURNAL; SPRAY DRYING; SYNTHESIS; X RAY PHOTOELECTRON SPECTROSCOPY;

EID: 1242272819     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2003.09.099     Document Type: Article

References (32)

1. Yolls S. Biodegradable polymeric articles for dispensing drugs. US patent 3,887,699, 1975.
2. Peppas N, Langer RS. Biopolymer I, Advances in Polymer Science, vol. 107. Berlin: Springer; 1993.
3. Gander B., Meinel M., Walter E., Merkle H.P. Polymers as a platform for drug delivery. reviewing our current portfolio on poly(lactide-co-glycolide) (PLGA) microspheres Chimia. 55:2001;212-217.
4. Ignatius A.A., Claes L.E. In vitro biocompatibility of bioresorbable polymers. poly(L,D-lactide) and poly(L-lactide-co-glycolide) Biomaterials. 17:1996;831-839.
5. Okada H., Toguchi H. Biodegradable microspheres in drug delivery. Crit Rev Ther Drug Carrier Syst. 12:1995;1-99.
6. Jain R., Shah N.H., Malick A.W., Rhodes C.T. Controlled drug delivery by biodegradable poly(ester) devices. different preparative approaches Drug Dev Ind Pharm. 24:1998;703-727.
7. Govender T., Stolnik S., Garnett M.C., Illum L., Davis S.S. PLGA nanoparticles prepared by nanoprecipitation. drug loading and release studies of a water soluble drug J Control Rel. 57:1999;171-185.
8. Takada H., Uda Y., Toguchi H., Ogawa Y. Application of a spray drying technique in the production of TRH-containing sustained release microparticles of biodegradable polymers. PDA J Pharm Sci Technol. 49:1995;180-184.
9. Perugini P, Genta I, Conti B, Modena T, Pavanetto F. Long-term release of clodronate from biodegradable microspheres. AAPS Pharm Sci Technol 2001;2 (Article 10).
10. Blanco-Prieto M.J., Fattal E., Gulik A., Dedieu J.C., Roques B.P., Couvreur P. Characterization and morphological analysis of a cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microspheres prepared by a water-in-oil-in-water emulsion solvent evaporation method. J Control Rel. 43:1997;81-87.
11. Fu K., Pack D.W., Klibanov A.M., Langer R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm Res. 17:2000;100-106.
12. Perez C., Sanchez A., Putnam D., Ting D., Langer R., Alonso M.J. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J Control Rel. 75:2001;211-224.
13. Lam X.M., Duenas E.T., Cleland J.L. Encapsulation and stabilization of nerve growth factor into poly(lavtic-co-glycolic) acid microspheres. J Pharm Sci. 90:2001;1356-1365.
14. Jignani M., Merkli A., Sintzel M.B., Bernatchez S.F., Kloeti W., Heller J., Tabatabay C., Gurny R. New generation of poly(ortho esters). synthesis, characterization, kinetics, sterilization and biocompatibility J Control Rel. 48:1997;115-129.
15. Weinhold A., Abdellaoui K.S., Barr J., Ng S.Y., Shen H.R., Gurny R., Heller J. Release of BSA from poly(ortho ester) extruded thin strands. J Control Rel. 71:2001;31-37.
16. Sintzel M.B., Heller J., Ng S.Y., Tabatabay C., Abdellaoui K.S., Gurny R. In vitro drug released from self-catalyzed poly(ortho ester). case study of 5-fluorouracil J Control Rel. 55:1998;213-218.
17. Heller J. Poly(ortho esters). Adv Polym Sci. 107:1993;41-92.
18. Ng S.Y., Vandamme T., Taylor M.S., Heller J. Synthesis and erosion studies of self catalysed poly(ortho-esters). Macromolecules. 30:1997;770-772.
19. Ng S.Y., Shen H.R., Lopez E., Zherebin Y., Barr J., Schacht E., Heller J. Development of a poly(ortho esters) prototype with a latent acid in the polymer backbone for 5-fluorouracyl delivery. J Control Rel. 65:2000;367-374.
20. Yang Y.Y., Wan J.P., Chung T.S., Pallathadka P.K., Ng S., Heller J. POE-PEG-POE triblock copolymeric microspheres containing protein I. Preparation and characterization. J Control Rel. 75:2001;115-128.
21. Wan J.P., Yang Y.Y., Chung T.S., Tan D., Ng S., Heller J. POE-PEG-POE triblock copolymeric microspheres containing protein II. Polymer erosion and protein release mechanism. J Control Rel. 75:2001;129-141.
22. Chia H.H., Yang Y.Y., Chung T.S. Auto-catalyzed poly(ortho ester) microspheres. a study on their erosion and drug release mechanism J Control Rel. 75:2001;11-25.
23. Wei M., Chang J., Yao K.D., Ng S., Heller J. Drug release from poly(ortho esters)-Poly(ehtylene glycol) polyblend. J Appl Polym Sci. 71:1999;303-309.
24. Leadbeater L. When all else fails [antidotes to chemical agents for troops]. Chem Br. 24:1988;683-688.
25. Tuovinen K., Korhonen E.K., Raushel F.M., Hänninen O. Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. Toxicology. 134:1999;169-178.
26. Solana R.P., Harris L.W., Carter W.H., Talbot B.G., Carchman U.A., Gennings C. Evaluation of a two-drug combination pretreatment against organophosphate exposure. Toxicol Appl Pharmacol. 102:1990;421-429.
27. Coelho Filho JM, Birks J. Physostigmine for Alzheimer's disease (Cochrane Review). In: The Cochrane Library 2001 (Article 2).
28. Krall W.J., Sramek J.J., Cutler N.R. Cholinesterase inhibitors. strategy for Alzheimer disease Ann Pharmacother. 33:1999;441-450.
29. Walter K., Muller M., Barkworth M.F., Nieciecki A.V., Stanislaus F. Pharmacokinetics of physostigmine in man following a single application of a transdermal system. Br J Clin Pharmacol. 39:1995;59-63.
30. Hartvig P., Wiklund L., Lindstrom B. Pharmacokinetics of physostigmine after intravenous, intramuscular and subcutaneous administration in surgical patients. Acta Anesthesilol Scand. 30:1986;177-182.
31. Rubnov S., Levy D., Schneider H. Liquid chromatographic analysis of physostigmine salicylate and its degradation products. J Pharm Biomed Anal. 18:2000;939-945.
32. Chaw C.S., Tan C.W., Yang Y.Y., Wang L., Moochhala S. Design of physostigmine-loaded polymeric microparticles for pretreatment against exposure to organophosphate agents. Biomaterials. 24:2003;1271-1277.