An Exposure-dependent Reduction of Lung Cancer Risk in Dairy Farmers: A Nested Case-referent Study

Indoor and Built Environment

Volumn 13, Issue 1, 2004, Pages 35-43

  Mastrangelo, Giuseppe ^a   Marzia, V ^a   Milana, G ^a   Fadda, E ^a   Fedeli, U ^a   Lange, J H ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b ENVIROSAFE TRAINING AND CONSULTANTS   (United States)

Author keywords

Case referent study; Crop farmers; Dairy farmers; Endotoxin; Epidemiology; Lung cancer; Orchard farmers

Indexed keywords

ENDOTOXIN;

ADULT; AGED; AGRICULTURAL WORKER; AIRBORNE INFECTION; ARTICLE; CALCULATION; CANCER RISK; COHORT ANALYSIS; CONFIDENCE INTERVAL; CROP PRODUCTION; DAIRY CATTLE; DAIRYING; ENVIRONMENTAL EXPOSURE; HUMAN; ITALY; LOGISTIC REGRESSION ANALYSIS; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OCCUPATIONAL EXPOSURE; ORCHARD; ORGANIC DUST; PRIORITY JOURNAL; PROTECTION; QUESTIONNAIRE; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SMOKING HABIT;

BOS TAURUS;

EID: 1242272209     PISSN: 1420326X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1420326X04036006     Document Type: Article

References (58)

1. Enterline PE, Sykora JL, Keleti G, Lange JH: Endotoxin, cotton dust and cancer. Lancet 1985;2:934-935.
2. Olenchock AS, May JJ, Pratt DS, Piacitelli LA, Parker JE: Presence of endotoxins in different agricultural environments. Am J Ind Med 1990;18:279-284.
3. Rask-Andersen A, Malberg P, Lundholm M: Endotoxin levels in farming: absence of symptoms despite high exposure levels. Br J Ind Med 1989;46:412-416.
4. Mastrangelo G, Marzia V, Marcer G: Reduced lung cancer mortality in diary farmers: is endotoxin exposure the key factor. Am J Ind Med 1996;30:601-609.
5. Reif J, Pearce N, Fraser J: Cancer risks in New Zealand farmers. Int J Epidemiol 1989;18:768-774.
6. Malmberg P: Health effects of organic dust exposure in dairy farmers. Am J Ind Med 1990;17:7-15.
7. Wiklund K, Steineck G: Cancer in respiratory organs of Swedish farmers. Cancer 1988;61:1055-1058.
8. Wiklund K, Dich J, Holm LE, Eklund G: Risk of cancer in pesticide applicators in Swedish agriculture. Br J Ind Med 1989;46:809-814.
9. Rafnsson V, Gunnarsdottir H: Mortality among farmers in Iceland. Int J Epidemiol 1989;18: 146-151.
10. Stark AD, Chang HG, Fitzgerald EF, Riccardi K, Stone RR: A retrospective cohort study of cancer incidence among New York State Farm Bureau members. Arch Environ Health 1990;45:155-162.
11. Hernberg S: Introduction to Occupational Epidemiology. Chelsea MI. Lewis Publishers Inc., 1992.
12. Lange JH: Reduced cancer rates in agricultural workers: a benefit of environmental and occupational endotoxin exposure. Med Hypotheses 2000;55:383-385.
13. Mehta C, Patel N (eds): StatXact for Windows. Cambridge, MA, Cytel Software Corporation, 1999.
14. Statistical Package for Social Scientists v II. Chicago, SPSS Inc.
15. Mehta C, Patel N (eds): LogXact for Windows. Cambridge, MA, Cytel Software Corporation. 1999.
16. Blair A, Malken H, Cantor KP, Burmeister L, Wiklund K: Cancer among farmers. Scand J Work Environ Health 1985;11: 397-407.
17. Brownson RC, Reif JS, Chang JC, Davis JR: Cancer risks among Missouri farmers. Cancer 1989;64:2381-2386.
18. Howe GR, Lindsay JP: A follow-up study of a ten-percent sample of Canadian labor force: I. cancer mortality in males, 1965-1973. J Natl. Cancer Inst 1983;70:37-44.
19. Petersen GR, Milham S Jr.: Occupational mortality in the state of California, 1959-1961. Rockville MD, National Institute for Occupational Safety and Health 1980. DHEW (NIOSH, NIH) Publ No 80-140:1980.
20. Olsen J, Jensen OM: Occupation and risk of cancer in Denmark: an analysis of 93810 cancer cases, 1970-1979. Scand J Work Environ Health 1987;13 Suppl 1:1-91.
21. Rylander R: Environmental exposures with decreased risks for lung cancer. Int J Epidemiol 1990;19:567-572.
22. Hodgson JT, Jones RD: Mortality of workers in the British cotton industry in 1968-1984. Scan J Work Environ Health 1990;16:113-120.
23. Rapiti E, Sperati A, Fano V, Dell'Orco V, Forastiere F: Mortality among workers at municipal waste incinerators in Rome: a retrospective cohort study. Am J Ind Med 1997; 31:659-661.
24. Schroeder JC, Tolbert PE, Eisen EA, Monson RR, Hallock MF, Smith TJ, Woskie SR, Hammond SK, Milton DK: Mortality studies of machining fluid exposure in the automotive industry IV: a case-control study of lung cancer. Am J Ind Med 1997;31:525-533.
25. Nativ O, Medalia O, Mor Y, Shajarawi I, Sabo E, Aronson M: Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding. Brit J Cancer 1996;74: 603-606.
26. Rudbach JA, Cantrell JL, Ulrich JT, Mitchell MS: Immunotherapy with bacterial endotoxins; in Friedmen H, Klien TW, Nakano M, Nowotny A, (eds): Endotoxin. Plenum Press, NY, 1988.
27. Zhang M, Tracey KJ: Endotoxin and cancer. in Brade H, Opal SM, Vogel SN, Morrison DC (eds): Endotoxin in Health and Disease. New York. Marcel Dekker, Inc., 1999, 915-926.
28. Lange JH: A statistical evaluation of asbestos air concentrations. Indoor-Built Environment 1999;8:293-303.
29. Kullman GJ, Thorne PS, Waldron PF, Marx JJ, Ault B, Lewis DM, Siegel PD, Olenchock SA, Merchant JA: Organic dust exposures from work in dairy barns. AIHAJ 1998;59: 403-411.
30. Cathomas RL, Bruesch H, Fehr R, Reinhart WH, Kuhn M: Organic dust exposure in dairy farmers in an alpine region. Swiss Med Wkly 2002;132:174-178.
31. Thorn J, Rylander R: Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique. Thorax 1998;53:1047-1052.
32. Fogelmark B, Sjostrand M, Rylander R: Pulmonary inflammation induced by repeated inhalation of beta(1,3)-D-glucan and endotoxin. Int J Exp Pathol 1994;74:85-90.
33. Christiani DC, Ye TT, Wegman DH, Eisen EA, Dai HL, Lu PL: Pulmonary function among cotton textile workers. A study of variability in symptom reporting, across-shift drop in FEV1, and longitudinal change. Chest 1994;105:1713-1721.
34. Simpson JCG, Niven RM, Pickering CAC, Fletcher AM, Oldham LA, Francis HM: Prevalence and predictors of work related respiratory symptoms in workers exposed to organic dusts. Occup Environ Med 1998;55:668-672.
35. Douwes J, McLean D, van der Maari E, Heederik D, Pearce N: Worker exposures to airborne dust, endotoxin and B(1,3)-glucan in two New Zealand sawmills. Am J Ind Med 2000;38:426-430.
36. Mandryk J, Alwis KU, Hocking AD: Work-related symptoms and dose-response relationships for personal exposures and pulmonary function among woodworkers. Am J Ind Med 1999;35:481-490.
37. Alwis KU, Mandryk J, Hocking AD: Exposure to biohazards in wood dust: Bacteria, fungi, endotoxins, and (1-3) beta D-glucans. Appl Occup Environ Hyg 1999;14:598-608.
38. Rylander R: Health effects among workers in sewage treatment plants. Occup Env Med 1999;56:354-357.
39. Lafleur J, Vena JE: Retrospective cohort mortality study of cancer among sewage workers. Am J Ind Med 1991;19:75-86.
40. Lange JH, Mastrangelo G, Thomulka KW: Will sewage workers with endotoxin-related symptoms have benefit of reduced lung cancer? Letter to the Editor. Occup Environ Med 2003;60:144-145.
41. Ryan LK, Karol MH: Release of tumor necrosis factor in guinea pigs upon acute inhalation of cotton dust. Am J Resp Cell and Molec Biol 1991;5:93.
42. O'Grady NP, Preas II HL, Pugin J, Fiuza C, Tropea M, Reda D, Banks SM, Suffredina AF: Local inflammatory responses following bronchial endotoxin instillation in humans. Am J Respir Crit Care Med 2001;163: 1591-1598.
43. Palmberg L, Larssson BM, Malmberg P, Larsson K: Airway response of healthy farmers and nonfarmers to exposure in swine confinement building. Scand J Work Environ Health 2002;28:256-263.
44. Michel O, Nagy AM, Schroeven M, Duchateau J, Neve J, Fondu P, Sergysels R: Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med 1997;156:1157-1164.
45. Wang Z, Larsson K, Palmberg L, Malmberg P, Larsson P, Larsson L: Inhalation of swine dust induces cytokine release in the upper and lower airways. Eur Respir J 1997;10:381-387.
46. Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, Schwartz DA: Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 1996;110:263-270.
47. Hirano S: Quantitative time-course profiles of bronchoalveolar lavage cells following intratracheal instillation of lipopolysaccharide in mice. Ind Health 1997;35:353-358.
48. Mastrangelo G, Fadda E, Milan G: Cancer increased after a reduction of infections in the first half of this century in Italy: etiologic and preventive implications. Eur J Epidemiol 1998;14:749-754.
49. Lange JH, Sykora JL, Weyel DA, Keleti G, Talbott EO: An animal model for evaluating epidemiological evidence of anti-lung cancer activity of aerosolized cotton dust. Proc of the Eleventh Cotton Dust Research Conference. RR Jacobs and PJ Wakelyn (eds), January 7-8, 1987, National Cotton Council, Memphis, TN, pp. 93-96.
50. Lange JH: Anti-cancer properties of inhaled cotton dust: a pilot experimental investigation. J Environ Sci Health 1992;27A:505-514.
51. Lange JH: An experimental study of anti-cancer properties of aerosolized endotoxin: application to human epidemiological studies. J Occup Med Toxicol 1992;1:377-382.
52. Andervent HB: The reaction of mice and of various mouse tumors to the injection of bacterial products. Am J Cancer 1936;27: 77-81.
53. Butler R: Enhancement of non-specific resistance to tumor by endotoxin; In Nowotny A (ed), Beneficial Effects of Endotoxin. Plenum Press, New York, NY, 1983.
54. Engelhardt R, Mackensen A, Galanos C: Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients. Cancer Research 1991;51:2524-2530.
55. Otto F, Schmid P, Mackensen A, Wehr U, Siez A, Braun M, Galanos C, Mertelsmann R, Engelhardt R: Phase II trail if intravenous endotoxin in patients with colorectal and non-small cell lung cancer. European J Cancer 1996;32A:1712-1718.
56. Reisser D, Pance A, Jeannin JF: Mechanisms of the antitumoral effect of lipid A. Bioessays 2002;24:284-289.
57. Pance A, Reisser D, Jeannin JF: Antitumoral effects of Lipid A: preclinical and clinical studies. J Investig Med 2002:50:173-178.
58. Hutchison GB: Evaluation of preventive services. J Chronic Dis 1960;11:497-502.