Rerouting nucleophilic substitution from the 4-position to the 2- or 6-position of 2,4-dihalopyridines and 2,4,6-trihalopyridines: The solution to a long-standing problem

Organic Letters

Volumn 7, Issue 1, 2005, Pages 127-129

  Schlosser, Manfred ^a   Rausis, Thierry ^a   Bobbio, Carla ^a  

^a Inst of Chem Sci and Engineering   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,6 TETRAFLUOROPYRIDINE; 2,4 DIFLUOROPYRIDINE; 2,4,6 TRICHLOROPYRIDINE; 2,4,6 TRIFLUOROPYRIDINE; HALOGEN; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; SUBSTITUTION REACTION;

EID: 12344333837     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol047826g     Document Type: Article

References (26)

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26. In reality, the yield is high but almost half of the product is lost upon steam distillation because of its extreme volatility.