Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins

Biochemistry

Volumn 44, Issue 3, 2005, Pages 1013-1025

  Zhao, Yue ^a   Thorngate, Fayanne E ^b   Weisgraber, Karl H ^c   Williams, David L ^b   Parks, John S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DENSITY (SPECIFIC GRAVITY); DISEASE CONTROL; ESTERS; LIQUID CHROMATOGRAPHY; PHYSIOLOGY; SUBSTRATES;

CHOLESTEROL ESTER (CE); CHOLESTEROL ESTERIFICATION RATE (CER); LECITHIN-CHOLESTEROL ACYLTRANSFERASE (LCAT); LOW-DENSITY LIPOPROTEIN (LDL);

PROTEINS;

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHOLESTEROL ESTER; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; RECOMBINANT ENZYME; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; ENZYME ACTIVITY; ENZYME SUBSTRATE; ESTERIFICATION; FAST PROTEIN LIQUID CHROMATOGRAPHY; GENOTYPE; ISOLATION PROCEDURE; ISOTOPE LABELING; MOUSE; NONHUMAN; PARTICLE SIZE; PLASMA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING;

ANIMALS; APOLIPOPROTEINS B; APOLIPOPROTEINS E; BASE SEQUENCE; DNA PRIMERS; ENZYME ACTIVATION; IMMUNOPRECIPITATION; MICE; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE;

EID: 12344322439     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0481489     Document Type: Article

References (53)

1. Buhman, K. F., Accad, M., and Farese, R. V. (2000) Mammalian acyl-CoA:cholesterol acyltransferases, Biochim. Biophys. Acta 1529, 142-154.
2. Rudel, L. L., Lee, R. G., and Cockman, T. L. (2001) Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis, Curr. Opin. Lipidol. 12, 121-127.
3. Jonas, A. (2000) Lecithin cholesterol acyltransferase, Biochim. Biophys. Acta 1529, 245-256.
4. Glomset, J. A. (1968) The plasma lecithin:cholesterol acyltransferase reaction, J. Lipid Res. 9, 155-167.
5. Liu, M., Bagdade, J. D., and Subbaiah, P. V. (1995) Specificity of lecithin:cholesterol acyltransferase and atherogenic risk: Comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species, J. Lipid Res. 36, 1813-1824.
6. Subbaiah, P. V., Liu, M., and Paltauf, F. (1994) Role of sn-2 acyl group of phosphatidylcholine in determining the positional specificity of lecithin-cholesterol acyltransferase, Biochemistry 33, 13259-13266.
7. Fielding, C. J., Shore, V. G., and Fielding, P. E. (1972) A protein cofactor of lecithin:cholesterol acyltransferase, Biochem. Biophys. Res. Commun. 46, 1493-1498.
8. Chen, C. H., and Albers, J. J. (1982) Distribution of lecithin-cholesterol acyltransferase (LCAT) in human plasma lipoprotein fractions. Evidence for the association of active LCAT with low-density lipoproteins, Biochem. Biophys. Res Commun. 107, 1091-1096.
9. Barter, P. J. (1983) Evidence that lecithin:cholesterol acyltransferase acts on both high- density and low-density lipoproteins, Biochim. Biophys. Acta 751, 261-270.
10. Barter, P. J., Hopkins, G. J., and Gorjatschko, L. (1984) Comparison of human plasma low- and high-density lipoproteins as substrates for lecithin: cholesterol acyltransferase, Biochim. Biophys. Acta 792, 1-5.
11. Rajaram, O. V., and Barter, P. J. (1985) Reactivity of human lipoproteins with purified lecithin: cholesterol acyltransferase during incubations in vitro, Biochim. Biophys. Acta 835, 41-49.
12. Carlson, L. A., and Holmquist, L. (1985) Evidence for the presence in human plasma of lecithin: cholesterol acyltransferase activity (beta-LCAT) specifically esterifying free cholesterol of combined pre-beta- and beta-lipoproteins. Studies of fish eye disease patients and control subjects, Acta Med. Scand. 218, 197-205.
13. Carlson, L. A., and Holmquist, L. (1985) Evidence for deficiency of high-density lipoprotein lecithin: cholesterol acyltransferase activity (alpha-LCAT) in fish eye disease, Acta Med. Scand. 218, 189-196.
14. Glomset, J. A., Norum, K. R., and King, W. (1970) Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: lipid composition and reactivity in vitro, J. Clin. Invest. 49, 1827-1837.
15. Norum, K. R., Glomset, J. A., Nichols, A. V., and Forte, T. (1971) Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high-density lipoproteins, J. Clin. Invest. 50, 1131-1140.
16. Forte, T. M., and Carlson, L. A. (1984) Electron microscopic structure of serum lipoproteins from patients with fish eye disease, Arteriosclerosis 4, 130-137.
17. Glomset, J. A., Nichols, A. V., Norum, K. R., King, W., and Forte, T. (1973) Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency. Further studies of very low and low-density lipoprotein abnormalities, J. Clin. Invest. 52, 1078-1092.
18. Norum, K. R., Glomset, J. A., Nichols, A. V., Forte, T., Albers, J. J., King, W. C., Mitchell, C. D., Applegate, K. R., Gong, E. L., Cabana, V., and Gjone, E. (1975) Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of incubation with lecithin: cholesterol acyltransferase in vitro, Scand. J. Clin. Lab. Invest. 35 (Suppl 142), 31-55.
19. Furbee, J. W., Jr., Francone, O. L., and Parks, J. S. (2002) In vivo contribution of lecithin:cholesterol acyltransferase (LCAT) to apolipoprotein B lipoprotein cholesteryl esters in low-density lipoprotein receptor and apolipoprotein E knockout mice, J. Lipid Res. 43, 428-437.
20. Jonas, A. (1991) Lecithin-cholesterol acyltransferase in the metabolism of high-density lipoproteins, Biochim. Biophys. Acta 1084, 205-220.
21. Cheung, M. C., Wang, D. B., Lum, K. D., and Albers, J. J. (1988) Cholesterol esterification by lecithin-cholesterol acyltransferase in A-I-free plasma, Biochim. Biophys. Acta 962, 258-264.
22. Parks, J. S., Li, H., Gebre, A. K., Smith, T. L., and Maeda, N. (1995) Effect of apolipoprotein A-I deficiency on lecithin: cholesterol acyltransferase activation in mouse plasma, J. Lipid Res. 36, 349-355.
23. Zorich, N., Jonas, A., and Pownall, H. J. (1985) Activation of lecithin cholesterol acyltransferase by human apolipoprotein E in discoidal complexes with lipids, J. Biol. Chem. 260, 8831-8837.
24. Alaupovic, P. (2003) The Concept of Apolipoprotein-defined Lipoprotein Families and Its Clinical Significance, Curr. Atheroscler. Rep. 5, 459-467.
25. Koren, E., Alaupovic, P., Lee, D. M., Dashti, N., Kloer, H. U., and Wen, G. (1987) Selective isolation of human plasma low-density lipoprotein particles containing apolipoproteins B and E by use of a monoclonal antibody to apolipoprotein B, Biochemistry 26, 2734-2740.
26. Farese, R. V., Jr., Veniant, M. M., Cham, C. M., Flynn, L. M., Pierotti, V., Loring, J. F., Traber, M., Ruland, S., Stokowski, R. S., Huszar, D., and Young, S. G. (1996) Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100, Proc. Natl. Acad. Sci. U.S.A. 93, 6393-6398.
27. Bligh, E. G., and Dyer, W. J. (1959) A rapid method of total lipid extraction and purification, Can. J. Med. Sci. 37, 911-917.
28. Rudel, L. L., Kelley, K., Sawyer, J. K., Shah, R., and Wilson, M. D. (1998) Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human ApoB100-over-expressing transgenic mice, Arterioscler. Thromb. Vasc. Biol. 18, 1818-1827.
29. Stokke, K. T., and Norum, K. R. (1971) Determination of lecithin: cholesterol acyltransfer in human blood plasma, Scand. J. Clin. Lab. Invest. 27, 21-27.
30. Parks, J. S., Gebre, A. K., and Furbee, J. W. (1999) Lecithin-cholesterol acyltransferase. Assay of cholesterol esterification and phospholipase A2 activities, Methods Mol. Biol. 109, 123-131.
31. Zhao, Y., Wang, J., Gebre, A. K., Chisholm, J. W., and Parks, J. S. (2003) Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains, Biochemistry 42, 13941-13949.
32. Morrow, J. A., Arnold, K. S., and Weisgraber, K. H. (1999) Functional Characterization of Apolipoprotein E Isoforms Over-expressed in Escherichia coli, Protein Expression Purif. 16, 224-230.
33. Nichols, A. V., Gong, E. L., Blanche, P. J., Forte, T. M., and Anderson, D. W. (1976) Effects of guanidine hydrochloride on human plasma high-density lipoproteins, Biochim. Biophys. Acta 446, 226-239.
34. Chisholm, J. W., Gebre, A. K., and Parks, J. S. (1999) Characterization of C-terminal histidine tagged human recombinant lecithin:cholesterol acyltransferase, J. Lipid Res. 40, 1512-1519.
35. Parks, J. S., and Rudel, L. L. (1982) Different kinetic fates of apolipoproteins A-I and A-II from lymph chylomicra of non-human primates. Effect of saturated versus polyunsaturated dietary fat, J. Lipid Res. 23, 410-421.
36. Furbee, J. W., Jr., Sawyer, J. K., and Parks, J. S. (2002) Lecithin: cholesterol acyltransferase deficiency increases atherosclerosis in the low-density lipoprotein receptor and apolipoprotein E knockout mice, J. Biol. Chem. 277, 3511-3519.
37. Albers, J. J., Chen, C. H., and Adolphson, J. L. (1981) Lecithin: cholesterol acyltransferase (LCAT) mass; its relationship to LCAT activity and cholesterol esterification rate, J. Lipid Res. 22, 1206-1213.
38. Lee, D. M., and Alaupovic, P. (1986) Apolipoproteins B, C-III and E in two major subpopulations of low-density lipoproteins, Biochim. Biophys. Acta 879, 126-133.
39. Mahley, R. W. (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology, Science 240, 622-630.
40. Swarnakar, S., Reyland, M. E., Deng, J., Azhar, S., and Williams, D. L. (1998) Selective Uptake of Low-Density Lipoprotein-Cholesteryl Ester Is Enhanced by Inducible Apolipoprotein E Expression in Cultured Mouse Adrenocortical Cells, J. Biol. Chem. 273, 12140-12147.
41. Lee, R. G., Kelly, K. K., Sawyer, J. K., Farese, R. V., Jr., Parks, J. S., and Rudel, L. L. (2004) Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme A:cholesterol acyltransferase 2 have opposite atherosclerotic potential, Circ. Res. 95, 988-1004.
42. Jonas, A. (2000) Lecithin cholesterol acyltransferase, Biochim. Biophys. Acta 1529, 245-256.
43. Reichl, D., and Sterchi, J. M. (1992) Human peripheral lymph lipoproteins are enriched in sphingomyelin, Biochim. Biophys. Acta Lipids Lipid Metab. 1127, 28-32.
44. Liu, M., Krul, E. S., and Subbaiah, P. V. (1992) Effect of apoprotein B conformation on the activation of lysolecithin acyltransferase and lecithin: cholesterol acyltransferase. Studies with subfractions of low-density lipoproteins, J. Biol. Chem. 267, 5139-5147.
45. Subbaiah, P. V., and Liu, M. (1993) Role of sphingomyelin in the regulation of cholesterol esterification in the plasma lipoproteins. Inhibition of lecithin-cholesterol acyltransferase reaction, J. Biol. Chem. 268, 20156-20163.
46. Jeong, T. S., Schissel, S. L., Tabas, I., Pownall, H. J., Tall, A. R., and Jiang, X. C. (1998) Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase, J. Clin. Invest. 101, 905-912.
47. Chajek, T., Aron, L., and Fielding, C. J. (1980) Interaction of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in the transport of cholesteryl ester into sphingomyelin liposomes, Biochemistry 19, 3673-3677.
48. Sparks, D. L., and Pritchard, P. H. (1989) The neutral lipid composition and size of recombinant high-density lipoproteins regulates lecithin:cholesterol acyltransferase activity, Biochem. Cell Biol. 67, 358-364.
49. Wald, J. H., Krul, E. S., and Jonas, A. (1990) Structure of apolipoprotein A-I in three homogeneous, reconstituted high-density lipoprotein particles, J Biol. Chem. 265, 20037-20043.
50. Sparks, D. L., Davidson, W. S., Lund-Katz, S., and Phillips, M. C. (1995) Effects of the neutral lipid content of high-density lipoprotein on apolipoprotein A-I structure and particle stability, J. Biol. Chem. 270, 26910-26917.
51. Peelman, F., Verschelde, J. L., Vanloo, B., Ampe, C., Labeur, C., Tavernier, J., Vandekerckhove, J., and Rosseneu, M. (1999) Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity, J. Lipid Res. 40, 59-69.
52. Thorngate, F. E., Yancey, P. G., Kellner-Weibel, G., Rudel, L. L., Rothblat, G. H., and Williams, D. L. (2003) Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression, J. Lipid Res. 44, 2331-2338.
53. Steinmetz, A., and Utermann, G. (1985) Activation of lecithin: cholesterol acyltransferase by human apolipoprotein A-IV, J. Biol. Chem. 260, 2258-2264.