Granulocyte colony-stimulating factor decreases tumor necrosis factor production in whole blood: Role of interleukin-10 and prostaglandin E 2

European Cytokine Network

Volumn 15, Issue 4, 2004, Pages 323-326

  Agnello, Davide ^a   Mascagni, Patrizia ^c   Bertini, Riccardo ^c   Villa, Pia ^a,b   Senaldi, Giorgio ^d   Ghezzi, Pietro ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b CNR   (Italy)

^c Chemistry Section   (Italy)

^d AMGEN INC   (United States)

Author keywords

Endotoxin; G CSF; IL 10; PGE 2; TNF

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; KETOPROFEN; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; MALE; MOUSE; NONHUMAN;

ANIMALS; BLOOD CELLS; CELLS, CULTURED; DINOPROSTONE; GRANULOCYTE COLONY-STIMULATING FACTOR; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MICE; TUMOR NECROSIS FACTORS;

ANIMALIA;

EID: 12344314080     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Hommes DW, Meenan J, Dijkhuizen S, Ten Kate FJ, Tytgat GN, Van Deventer SJ. Efficacy of recombinant granulocyte colony-stimulating factor (rhG-CSF) in experimental colitis. Clin Exp Immunol 1996; 106: 529.
2. Aoki Y, Hiromatsu K, Kobayashi N, et al. Protective effect of granulocyte colony-stimulating factor against T-cell-meditated lethal shock triggered by superantigens. Blood 1995; 86: 1420.
3. Zeng D, Dejbakhsh-Jones S, Strober S. Granulocyte colony-stimulating factor reduces the capacity of blood mononuclear cells to induce graft-versus-host disease: impact on blood progenitor cell transplantation. Blood 1997; 90: 453.
4. Pan L, Teshima T, Hill GR, et al. Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood 1999; 93: 4071.
5. Reddy V, Hill GR, Pan L, et al. G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient. Transplantation 2000; 69: 691.
6. Remberger M, Naseh N, Aschan J, et al. G-CSF given after haematopoietic stem cell transplantation using HLA-identical sibling donors is associated to a higher incidence of acute GVHD II-IV. Bone Marrow Transplant 2003; 32: 217.
7. Ringden O, Labopin M, Gorin NC, et al. Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol 2004; 22: 416.
8. Hartung T, Docke WD, Gantner F, et al. Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood 1995; 85: 2482.
9. Dalhoff K, Hansen F, Dromann D, Schaaf B, Aries SP, Braun J. Inhibition of neutrophil apoptosis and modulation of the inflammatory response by granulocyte colony-stimulating factor in healthy and ethanol-treated human volunteers. J Infect Dis 1998; 178: 891.
10. Boneberg EM, Hareng L, Gantner F, Wendel A, Hartung T. Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-gamma. Blood 2000; 95: 270.
11. Hartung T, Doecke WD, Bundschuh D, et al. Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions. Clin Pharmacol Ther 1999; 66: 415.
12. Aggarwal BB, Kohr WJ, Hass PE, et al. Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem 1985; 260: 2345.
13. Mielcarek M, Martin PJ, Torok-Storb B. Suppression of alloantigen-induced T-cell proliferation by CD14+ cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. Blood 1997; 89: 1629.
14. Mielcarek M, Graf L, Johnson G, Torok-Storb B. Production of interleukin-10 by granulocyte colony-stimulating factor-mobilized blood products: a mechanism for monocyte-mediated suppression of T-cell proliferation. Blood 1998; 92: 215.
15. Kunkel SL, Spengler M, May MA, Spengler R, Larrick J, Remick D. Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. J Biol Chem 1988; 263: 5380.
16. Renz H, Gong JH, Schmidt A, Nain M, Gemsa D. Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides. J Immunol 1988; 141: 2388.
17. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209.
18. Berg DJ, Kuhn R, Rajewsky K, et al. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest 1995; 96: 2339.
19. Agnello D, Villa P, Ghezzi P. Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10- deficient mice. Brain Res 2000; 869: 241.
20. Pettipher ER, Wimberly DJ. Cyclooxygenase inhibitors enhance tumour necrosis factor production and mortality in murine endotoxic shock. Cytokine 1994; 6: 500.
21. Sironi M, Gadina M, Kankova M, et al. Differential sensitivity of in vivo TNF and IL-6 production to modulation by anti-inflammatory drugs in mice. Int J Immunopharmacol 1992; 14: 1045.
22. Martich GD, Danner RL, Ceska M, Suffredini AF. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. J Exp Med 1991; 173: 1021.
23. Berg DJ, Zhang J, Lauricella DM, Moore SA. Il-10 is a central regulator of cyclooxygenase-2 expression and prostaglandin production. J Immunol 2001; 166: 2674.
24. Niiro H, Otsuka T, Kuga S, et al. IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes. Int Immunol 1994; 6: 661.
25. Kambayashi T, Alexander HR, Fong M, Strassmann G. Potential involvement of IL-10 in suppressing tumor-associated macrophages. Colon-26-derived prostaglandin E2 inhibits TNF-alpha release via a mechanism involving IL-10. J Immunol 1995; 154: 3383.