Functional and structural postglomerular alterations in the kidney of prehypertensive spontaneously hypertensive rats

Clinical and Experimental Hypertension

Volumn 26, Issue 7-8, 2004, Pages 663-672

  Baumann, Marcus ^a   Van Essen, Helma ^a   Hermans, J J Rob ^a   Smits, Jos F M ^a   Struijker Boudier, Harry A J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Hypertension; Prehypertensive SHR; Renal excretory function; Vasa recta

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CREATININE; PHOSPHORUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD PRESSURE; BODY WEIGHT; CONFERENCE PAPER; COUNTERCURRENT SYSTEM; CREATININE CLEARANCE; ELECTROLYTE BALANCE; GEOMETRY; HYPERTENSION; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY FUNCTION; KIDNEY MASS; KIDNEY MEDULLA; KIDNEY STRUCTURE; KIDNEY TUBULE ABSORPTION; MEAN ARTERIAL PRESSURE; NONHUMAN; PARAMETER; PERICYTE; PHOSPHATE METABOLISM; RAT; RAT STRAIN; SPONTANEOUSLY HYPERTENSIVE RAT; URINE OSMOLALITY;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; CREATININE; HYPERTENSION, RENAL; KIDNEY GLOMERULUS; ORGAN SIZE; PHOSPHORUS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RENAL CIRCULATION; WATER-ELECTROLYTE BALANCE;

EID: 12344281003     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.1081/CEH-200031969     Document Type: Conference Paper

References (22)

1. Guyton AC, Coleman TG, Cowley AV Jr, Scheel KW, Manning RD Jr, Norman RA Jr. Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 1972; 52:584-594.
2. Borst JGG, Borst-de Geus A. Hypertension explained by Starling's law of circulatory homeostasis. Lancet 1963; 1:677-680.
3. Johnson RJ, Rodriguez-Iturbe B, Schreiner GF, Herrera-Acosta J. Hypertension: a microvascular and tubulointerstitial disease. J Hypertens 2002; 20(suppl 3):S1-S7.
4. Hall JE, Brands MW, Henegar JR. Mechanisms of hypertension and kidney disease in obesity. Ann NY Acad Sci 1999; 892:91-107.
5. Brenner BM, Lawler EV, Mackenzie HS. The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 1996; 49:1774-1777.
6. Skov K, Nyengaard JR, Korsgaard N, Mulvany MJ. Number and size of renal glomeruli in spontaneously hypertensive rats. J Hypertens 1994; 12:1373-1376.
7. Keller G, Zimmer G, Mall G, Ritz E, Amann K. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348:101-108.
8. Imig JD, Falck JR, Gebremedhin D, Harder DR, Roman RJ. Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. Hypertension 1993; 22:357-364.
9. Silveira LA, Bacchi CE, Pinto GA, De Faria JB. The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes. Diabetes 2002; 51:1529-1534.
10. Mullins MM. Body fluid volumes in prehypertensive spontaneously hypertensive rats. Am J Physiol 1983; 244:H652-H655.
11. Knox FG, Burnett JC Jr, Kohan DE, Spielman WS, Strand JC. Escape from the sodium-retaining effects of mineralocorticoids. Kidney Int 1980; 17:263-276.
12. Roman RJ, Kaldunski ML. Renal cortical and papillary blood flow in spontaneously hypertensive rats. Hypertension 1988; 11:657-663.
13. Cowley AW Jr. Role of the renal medulla in volume and arterial pressure regulation. Am J Physiol 1997; 273:R1-R15.
14. Park F, Mattson DL, Roberts LA, Cowley AW Jr. Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla. Am J Physiol 1997; 273:R1742-R1748.
15. Janssen BJ, Struijker Boudier HA, Smits JF. Role of afferent renal nerves in renal adaptation to sodium restriction in uninephrectomized rats. Acta Physiol Scand 1994; 151:395-402.
16. Mullins MM, Banks RO. Age-related changes in Na+ excretion in saline-loaded spontaneously hypertensive rats. Am J Physiol 1976; 231:1364-1370.
17. Edwards A, Delong MJ, Pallone TL. Interstitial water and solute recovery by inner medullary vasa recta. Am J Physiol Renal Physiol 2000; 278:F257-F269.
18. Maric C, Ryan GB, Alcorn D. Embryonic and postnatal development of the rat renal interstitium. Anat Embryol (Berl) 1997; 195:503-514.
19. Hellstrom M, M Kn, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999; 126:3047-3055.
20. Badzynska B, Grzelec-Mojzesowicz M, Dobrowolski L, Sadowski J. Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats. J Physiol 2002; 538:159-166.
21. Bandopadhyay R, Orte C, Lawrenson JG, Reid AR, De Suva S, Allt G. Contractile proteins in pericytes at the blood-brain and blood-retinal barriers. J Neurocytol 2001; 30:35-44.
22. Marie C, Casley D, Harris P, Alcorn D. Angiotensin II binding to renomedullary interstitial cells is regulated by osmolality. J Am Soc Nephrol 2001; 12:450-455.