Eosinophil: Central mediator of allergic asthma?

Chinese Medical Journal

Volumn 118, Issue 1, 2005, Pages 4-5

  Shen, Hua Hao ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 5 RECEPTOR; MONOCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL MODEL; ANTIGEN PRESENTING CELL; BRONCHUS HYPERREACTIVITY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG TARGETING; EDITORIAL; EOSINOPHIL; GENE DELETION; HYPOTHESIS; IMMUNOREGULATION; KNOCKOUT MOUSE; LOEFFLER PNEUMONIA; LUNG INFILTRATE; MEDIATOR RELEASE; MOUSE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; RESPIRATORY TRACT INFLAMMATION; T LYMPHOCYTE ACTIVATION; TH2 CELL; TISSUE REPAIR; WILD TYPE;

ANIMALS; ASTHMA; EOSINOPHILS; MICE;

EID: 12344280100     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (11)

1. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001;344:350-362.
2. Hirsch JG. Paul Ehrlich and the discovery of the eosinophil. In: Mahmoud AAF, Austen KF, eds. The eosinophil in health and disease. New York: Grune & Stratton; 1980:3-23.
3. Lampinen M, Carlson M, Hakansson LD, et al. Cytokine-regulated accumulation of eosinophils in inflammatory disease. Allergy 2004;59:793-805.
4. Busse WW, Calhoun WF, Sedgwick JD. Mechanism of airway inflammation in asthma. Am Rev Respir Dis 1993;147 (6 Pt 2):S20-S24.
5. Gonzalo JA, Lloyd CM, Kremer L. Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors. J Clin Invest 1996;98:2332-2345.
6. Leckie MJ, ten Brinke A, Knan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness and the late asthmatic response. Lancet 2000;356:2144-2148.
7. Flood-Page PT, Menzies-Gow AN, Kay AB, et al. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003;167:199-204.
8. Shen HH, Ochkur SI, McGarry MP, et al. Causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. J Immunol 2003;170:3296-3305.
9. Cho JY, Miller M, Baek KJ, et al. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 2004; 113:551-560.
10. Xie ZF, Shi HZ, On XJ, et al. Effects of antigen presentation of eosinophils on lung Th1/Th2 imbalance. Chin Med J 2005;118:6-11.
11. Williams TJ . The eosinophil enigma. J Clin Invest 2004;113:507-509.