Thyroid disorders associated with pregnancy: Etiology, diagnosis, and management

Treatments in Endocrinology

Volumn 4, Issue 1, 2005, Pages 31-41

  Lazarus, John H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BINDING PROTEIN; CARBIMAZOLE; CORTICOSTEROID; GRANULOCYTE COLONY STIMULATING FACTOR; IODIDE; IODINE; IODINE 131; LEVOTHYROXINE; LITHIUM; PREDNISONE; PROPRANOLOL; PROPYLTHIOURACIL; RADIOACTIVE IODINE; THIAMAZOLE; THIONAMIDE; THYROID ANTIBODY; THYROID BINDING PROTEIN; THYROID PEROXIDASE ANTIBODY; THYROTROPIN RECEPTOR ANTIBODY; THYROXINE; UNCLASSIFIED DRUG; VERAPAMIL;

AGRANULOCYTOSIS; ARTHRALGIA; DISEASE EXACERBATION; DISEASE PREDISPOSITION; DRUG CONTRAINDICATION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; EMBRYOPATHY; ENDOCRINE OPHTHALMOPATHY; ENDOCRINE SYSTEM; FEMALE; FEMALE INFERTILITY; FETOTOXICITY; FETUS DISEASE; FETUS MONITORING; HUMAN; HYPEREMESIS GRAVIDARUM; HYPERTHYROIDISM; HYPOTHYROIDISM; IMMUNE SYSTEM; INTELLIGENCE QUOTIENT; IODINE DEFICIENCY; MATERNAL DISEASE; MEDICATION ERROR; NAUSEA; NERVOUS SYSTEM DEVELOPMENT; NEWBORN DISEASE; NEWBORN MORBIDITY; POSTPARTUM THYROIDITIS; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY DISORDER; PRIORITY JOURNAL; PUERPERAL DISORDER; RADIOISOTOPE THERAPY; RASH; REVIEW; SCREENING; SKIN APLASIA; SUBACUTE THYROIDITIS; SUBTOTAL THYROIDECTOMY; TERATOGENICITY; TH1 CELL; TH2 CELL; THYROID CRISIS; THYROID DISEASE; THYROID FUNCTION; THYROID FUNCTION TEST; THYROID HORMONE BLOOD LEVEL; THYROID NODULE; THYROIDITIS; THYROTOXICOSIS; TOXIC GOITER; VASCULITIS;

ABORTION, SPONTANEOUS; AUTOANTIBODIES; FEMALE; GOITER, NODULAR; GRAVES DISEASE; HUMANS; HYPEREMESIS GRAVIDARUM; HYPERTHYROIDISM; IODINE RADIOISOTOPES; PREGNANCY; PREGNANCY COMPLICATIONS; PUERPERAL DISORDERS; THYROID DISEASES; THYROID GLAND; THYROID NODULE; THYROIDITIS, SUBACUTE;

EID: 12344270869     PISSN: 11756349     EISSN: None     Source Type: Journal    
DOI: 10.2165/00024677-200504010-00004     Document Type: Review

References (55)

1. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 1997; 18: 871-87
2. Weetman AP. The immunology of pregnancy. Thyroid 1999; 9: 643-6
3. Brent GA. Maternal thyroid function: interpretation of thyroid function tests in pregnancy. Clin Obstet Gynecol 1997; 40: 3-15
4. Glinoer D. Thyroid regulation and dysfunction in the pregnant patient [online]. Available from URL: http://www.thyroidmanager.org [Accessed 2003 Mar 21]
5. Burrow GN, Golden LH. Thyroid disease during pregnancy [online]. Available from URL: http://www.endotext.org [Accessed 2003 Mar 21]
6. Caron P, Hoff M, Bazzi S, et al. Urinary iodine excretion during normal pregnancy in healthy women living in the southwest of France: correlation with maternal thyroid parameters. Thyroid 1997; 7 (5): 749-54
7. Elnagar B, Eltom A, Wide L, et al. Iodine status, thyroid function and pregnancy: study of Swedish and Sudanese women. Eur J Clin Nutr 1998; 53: 351-5
8. Glinoer D. The regulation of thyroid function during normal pregnancy: importance of the iodine nutrition status. Best Pract Res Clin Endocrinol Metab 2004; 18(2): 133-52
9. Knudsen N, Laurberg P, Perrild H, et al. Risk factors for goiter and thyroid nodules. Thyroid 2002; 12 (10): 879-88
10. d'Herbomez M, Forzy G, Gasser F, et al. Clinical evaluation of nine free thyroxine assays: persistent problems in particular populations. Clin Chem Lab Med 2003; 41 (7): 942-7
11. Russell AS. Biology of human pregnancy: immune modulation (Th1 and Th2 responses in pregnancy). Scand J Rheumatol 1998; 27: 14-7
12. Iwatani Y, Amino N, Tachi J, et al. Changes of lymphocyte subsets in normal pregnant and postpartum women: postpartum increase of NK/K (Leu 7) cells. Am J Reprod Immunol Microbiol 1988; 18: 52-5
13. Szekeres-Bartho J. Immunological relationship between the mother and the fetus. Int Rev Immunol 2002; 21: 471-95
14. Saito S, Sakai M, Sasaki K, et al. Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1: Th2 cell ratio during normal human pregnancy and pre-eclampsia. Clin Exp Immunol 1999; 117: 550-5
15. Kincade PW, Medina KL, Payne KJ, et al. Early B-lymphocyte precursors and their regulation by sex steroids. Immunol Rev 2000; 175: 128-37
16. Davies TF. The thyroid immunology of the postpartum period. Thyroid 1999; 9: 675-84
17. Hall R. Pregnancy and autoimmune endocrine disease. Baillieres Clin Endocrinol Metab 1995; 9: 137-55
18. Elenkov IJ, Wilder RL, Bakalov VK, et al. IL-12, TNF-α, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab 2001; 86: 4933-8
19. Kim CH, Chae HD, Kang BM, et al. Influence of antithyroid antibodies in euthyroid women on in vitro fertilization-embryo transfer outcome. Am J Reprod Immunol 1998; 40: 2-8
20. Mecacci F, Parretti E, Cioni R, et al. Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of pregnancy loss or pre-eclampsia. J Reprod Immunol 2000; 46: 39-50
21. Bussen S, Steck T, Dietl J. Increased prevalence of thyroid antibodies in euthyroid women with a history of recurrent in-vitro fertilization failure. Hum Reprod 2002; 15: 545-8
22. Abramson J, Stagnaro-Green A. Thyroid antibodies and fetal loss: an evolving story. Thyroid 2001; 11: 57-63
23. Lazarus JH, Kokandi A. Thyroid disease in relation to pregnancy: a decade of change. Clin Endocrinol 2000; 53 (3): 265-78
24. Rodien P, Bremont C, Sanson ML, et al. Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. N Engl J Med 1998; 339 (25): 1823-6
25. Baloch Z, Carayon P, Conte-Devolx B, et al. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 2003; 13 (1): 3-126
26. Maziukiewicz UR, Burrow GN. Hyperthyroidism in pregnancy, diagnosis and treatment. Thyroid 1999; 9 (7): 647-52
27. Millar LK, Wing DA, Leung AS, et al. Low birth weight and pre-eclampsia in pregnancies complicated by hyperthyroidism. Obstet Gynecol 1994; 84: 946-9
28. Hamburger JI. Diagnosis and management of Graves' disease in pregnancy. Thyroid 1992; 2: 219-24
29. Kung AWC, Jones BM. A change from stimulatory to blocking antibody activity in Graves' disease during pregnancy. J Clin Endocrinol Metabol 1998; 83: 514-8
30. Zakarija M, De Forteza R, McKenzie JM, et al. Characteristics and clinical correlates of a novel thyroid-stimulating autoantibody. Autoimmunity 1994; 19 (1): 31-7
31. Mestman JH. Hyperthyroidism in pregnancy. Endocrinol Metab Clin North Am 1998; 27: 127-49
32. Laurberg P, Nygaard B, Glinoer D, et al. Guidelines for TSH-receptor antibody measurements in pregnancy: results of an evidence-based symposium organized by the European Thyroid Association. Eur J Endocrinol 1998; 139 (6): 584-6
33. Zanzonico PB, Becker DV. Radiation hazards in children born to mothers exposed to 131-iodine. In: Beckers C, Reinwein D, editors. The thyroid and pregnancy, international MERCK symposium. Brussels: Schattauer, 1991: 189-202
34. Mandel SJ, Cooper DS. The use of antithyroid drugs in pregnancy and lactation. J Clin Endocrinol Metab 2001; 86: 2354-9
35. Karlsson FA. Severe embryopathy and exposure to methimazole in early pregnancy. J Clin Endocrinol Metab 2002; 87 (2): 947-9
36. Hashizume K, Ichikawa K, Nishii Y, et al. Effect of administration of thyroxine on the risk of postpartum recurrence of hyperthyroid Graves' disease. J Clin Endocrinol Metab 1992; 75: 6-10
37. Gonzalez-Jimenez A, Fernandez-Soto ML, Escobar-Jimenez F, et al. Thyroid function parameters and TSH-receptor antibodies in healthy subjects and Graves' disease patients: a sequential study before, during and after pregnancy. Thyroidology 1993; 5: 13-20
38. Lazarus JH, Ludgate ME. Prevention and treatment of postpartum Graves' disease. Baillieres Clin Endocrinol Metab 1997; 11 (3): 549-60
39. Klein RZ, Haddow JE, Faixt JD, et al. Prevalence of thyroid deficiency in pregnant women. Clin Endocrinol 1991; 35: 41-6
40. Morreale de Escobar G, Obregon MJ, del Rey F. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 2000; 85: 3975-87
41. Alexander EK, Marqusee E, Lawrence J, et al. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med 2004; 351 (3): 241-9
42. Chin WW, Yen PM. Molecular mechanisms of nuclear thyroid hormone action. In: Braverman LE, editor. Diseases of the thyroid. Totowa (NJ): Humana Press Inc., 2003: 1-19
43. Bernal J. Action of thyroid hormone in brain. J Endocrinol Investig 2002; 25: 268-88
44. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999; 341: 549-55
45. Pop VJ, Kuijpens JL, van Baar AL, et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol 1999; 50: 147-8
46. Pop VJ, de Vries E, van Baar AL, et al. Maternal thyroid peroxidase antibodies during pregnancy: a marker of impaired child development? J Clin Endocrinol Metab 1995; 80: 3561-6
47. Man EB, Serunian SA. Thyroid function in human pregnancy: IX. Development or retardation of 7-year-old progeny of hypothyroxinemic women [abstract]. Am J Obstet Gynecol 1976; 125: 949
48. Hay I. Nodular thyroid disease diagnosed during pregnancy: how and when to treat. Thyroid 1999; 9 (7): 667-70
49. Choe W, McDougall IR. Thyroid cancer in pregnant women: diagnostic and therapeutic management. Thyroid 1994; 4: 433-5
50. Schlumberger M, De Vathaire F, Ceccarelli C, et al. Exposure to radioactive iodine-131 scintigraphy or therapy does not preclude pregnancy in thyroid cancer patients. J Nucl Med 1996; 37: 612-5
51. Lazarus JH, Hall R, Othman S, et al. The clinical spectrum of postpartum thyroid disease. QJM 1996; 89: 429-35
52. Muller AF, Drexhage HA, Berghout A. Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. Endocr Rev 2001; 22: 605-30
53. Lazarus JH, Premawardhana LD, Parkes AB. Postpartum thyroiditis. Autoimmunity 2002; 35: 169-73
54. Wass J, Shalet S, editors. Oxford textbook of endocrinology. Oxford: Oxford University Press, 2002
55. Premawardhana LD, Parkes AB, Ammari F, et al. Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. J Clin Endocrinol Metab 2000; 85: 71-5